Phosphonic Acid Coupling Agent Modification of HAP Nanoparticles: Interfacial Effects in PLLA/HAP Bone Scaffold
In order to improve the interfacial bonding between hydroxyapatite (HAP) and poly-l-lactic acid (PLLA), 2-Carboxyethylphosphonic acid (CEPA), a phosphonic acid coupling agent, was introduced to modify HAP nanoparticles. After this. the PLLA scaffold containing CEPA-modified HAP (C-HAP) was fabricate...
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doaj-958e1f1ed6a7499c867a22bd934cdb8b2020-11-25T01:45:50ZengMDPI AGPolymers2073-43602020-01-0112119910.3390/polym12010199polym12010199Phosphonic Acid Coupling Agent Modification of HAP Nanoparticles: Interfacial Effects in PLLA/HAP Bone ScaffoldCijun Shuai0Li Yu1Wenjing Yang2Shuping Peng3Yancheng Zhong4Pei Feng5State Key Laboratory of High Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, ChinaState Key Laboratory of High Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, ChinaState Key Laboratory of High Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, ChinaCancer Research Institute, School of Basic Medical Sciences, Central South University, Changsha 410013, ChinaCancer Research Institute, School of Basic Medical Sciences, Central South University, Changsha 410013, ChinaState Key Laboratory of High Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, ChinaIn order to improve the interfacial bonding between hydroxyapatite (HAP) and poly-l-lactic acid (PLLA), 2-Carboxyethylphosphonic acid (CEPA), a phosphonic acid coupling agent, was introduced to modify HAP nanoparticles. After this. the PLLA scaffold containing CEPA-modified HAP (C-HAP) was fabricated by selective laser sintering (frittage). The specific mechanism of interfacial bonding was that the PO<sub>3</sub><sup>2−</sup> of CEPA formed an electrovalent bond with the Ca<sup>2+</sup> of HAP on one hand, and on the other hand, the −COOH of CEPA formed an ester bond with the −OH of PLLA via an esterification reaction. The results showed that C-HAP was homogeneously dispersed in the PLLA matrix and that it exhibited interconnected morphology pulled out from the PLLA matrix due to the enhanced interfacial bonding. As a result, the tensile strength and modulus of the scaffold with 20% C-HAP increased by 1.40 and 2.79 times compared to that of the scaffold with HAP, respectively. In addition, the scaffold could attract Ca<sup>2+</sup> in simulated body fluid (SBF) solution by the phosphonic acid group to induce apatite layer formation and also release Ca<sup>2+</sup> and PO<sub>4</sub><sup>3−</sup> by degradation to facilitate cell attachment, growth and proliferation.https://www.mdpi.com/2073-4360/12/1/199interfacial bondingcoupling agenthapscaffold |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cijun Shuai Li Yu Wenjing Yang Shuping Peng Yancheng Zhong Pei Feng |
spellingShingle |
Cijun Shuai Li Yu Wenjing Yang Shuping Peng Yancheng Zhong Pei Feng Phosphonic Acid Coupling Agent Modification of HAP Nanoparticles: Interfacial Effects in PLLA/HAP Bone Scaffold Polymers interfacial bonding coupling agent hap scaffold |
author_facet |
Cijun Shuai Li Yu Wenjing Yang Shuping Peng Yancheng Zhong Pei Feng |
author_sort |
Cijun Shuai |
title |
Phosphonic Acid Coupling Agent Modification of HAP Nanoparticles: Interfacial Effects in PLLA/HAP Bone Scaffold |
title_short |
Phosphonic Acid Coupling Agent Modification of HAP Nanoparticles: Interfacial Effects in PLLA/HAP Bone Scaffold |
title_full |
Phosphonic Acid Coupling Agent Modification of HAP Nanoparticles: Interfacial Effects in PLLA/HAP Bone Scaffold |
title_fullStr |
Phosphonic Acid Coupling Agent Modification of HAP Nanoparticles: Interfacial Effects in PLLA/HAP Bone Scaffold |
title_full_unstemmed |
Phosphonic Acid Coupling Agent Modification of HAP Nanoparticles: Interfacial Effects in PLLA/HAP Bone Scaffold |
title_sort |
phosphonic acid coupling agent modification of hap nanoparticles: interfacial effects in plla/hap bone scaffold |
publisher |
MDPI AG |
series |
Polymers |
issn |
2073-4360 |
publishDate |
2020-01-01 |
description |
In order to improve the interfacial bonding between hydroxyapatite (HAP) and poly-l-lactic acid (PLLA), 2-Carboxyethylphosphonic acid (CEPA), a phosphonic acid coupling agent, was introduced to modify HAP nanoparticles. After this. the PLLA scaffold containing CEPA-modified HAP (C-HAP) was fabricated by selective laser sintering (frittage). The specific mechanism of interfacial bonding was that the PO<sub>3</sub><sup>2−</sup> of CEPA formed an electrovalent bond with the Ca<sup>2+</sup> of HAP on one hand, and on the other hand, the −COOH of CEPA formed an ester bond with the −OH of PLLA via an esterification reaction. The results showed that C-HAP was homogeneously dispersed in the PLLA matrix and that it exhibited interconnected morphology pulled out from the PLLA matrix due to the enhanced interfacial bonding. As a result, the tensile strength and modulus of the scaffold with 20% C-HAP increased by 1.40 and 2.79 times compared to that of the scaffold with HAP, respectively. In addition, the scaffold could attract Ca<sup>2+</sup> in simulated body fluid (SBF) solution by the phosphonic acid group to induce apatite layer formation and also release Ca<sup>2+</sup> and PO<sub>4</sub><sup>3−</sup> by degradation to facilitate cell attachment, growth and proliferation. |
topic |
interfacial bonding coupling agent hap scaffold |
url |
https://www.mdpi.com/2073-4360/12/1/199 |
work_keys_str_mv |
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