Vibrio vulnificus Hemolysin: Biological Activity, Regulation of vvhA Expression, and Role in Pathogenesis
The Vibrio vulnificus (V. vulnificus) hemolysin (VVH) is a pore-forming cholesterol-dependent cytolysin (CDC). Although there has been some debate surrounding the in vivo virulence effects of the VVH, it is becoming increasingly clear that it drives different cellular outcomes and is involved in the...
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doaj-959b10757e8b4c6f8bb4d71c7897bb352020-11-25T03:52:46ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-10-011110.3389/fimmu.2020.599439599439Vibrio vulnificus Hemolysin: Biological Activity, Regulation of vvhA Expression, and Role in PathogenesisYuan YuanZihan FengJinglin WangThe Vibrio vulnificus (V. vulnificus) hemolysin (VVH) is a pore-forming cholesterol-dependent cytolysin (CDC). Although there has been some debate surrounding the in vivo virulence effects of the VVH, it is becoming increasingly clear that it drives different cellular outcomes and is involved in the pathogenesis of V. vulnificus. This minireview outlines recent advances in our understanding of the regulation of vvhA gene expression, the biological activity of the VVH and its role in pathogenesis. An in-depth examination of the role of the VVH in V. vulnificus pathogenesis will help reveal the potential targets for therapeutic and preventive interventions to treat fatal V. vulnificus septicemia in humans. Future directions in VVH research will also be discussed.https://www.frontiersin.org/articles/10.3389/fimmu.2020.599439/fullVibrio vulnificus hemolysin (VVH)cholesterol-dependent cytolysin (CDC)biological activitygene regulationsepsispathogenesis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yuan Yuan Zihan Feng Jinglin Wang |
spellingShingle |
Yuan Yuan Zihan Feng Jinglin Wang Vibrio vulnificus Hemolysin: Biological Activity, Regulation of vvhA Expression, and Role in Pathogenesis Frontiers in Immunology Vibrio vulnificus hemolysin (VVH) cholesterol-dependent cytolysin (CDC) biological activity gene regulation sepsis pathogenesis |
author_facet |
Yuan Yuan Zihan Feng Jinglin Wang |
author_sort |
Yuan Yuan |
title |
Vibrio vulnificus Hemolysin: Biological Activity, Regulation of vvhA Expression, and Role in Pathogenesis |
title_short |
Vibrio vulnificus Hemolysin: Biological Activity, Regulation of vvhA Expression, and Role in Pathogenesis |
title_full |
Vibrio vulnificus Hemolysin: Biological Activity, Regulation of vvhA Expression, and Role in Pathogenesis |
title_fullStr |
Vibrio vulnificus Hemolysin: Biological Activity, Regulation of vvhA Expression, and Role in Pathogenesis |
title_full_unstemmed |
Vibrio vulnificus Hemolysin: Biological Activity, Regulation of vvhA Expression, and Role in Pathogenesis |
title_sort |
vibrio vulnificus hemolysin: biological activity, regulation of vvha expression, and role in pathogenesis |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2020-10-01 |
description |
The Vibrio vulnificus (V. vulnificus) hemolysin (VVH) is a pore-forming cholesterol-dependent cytolysin (CDC). Although there has been some debate surrounding the in vivo virulence effects of the VVH, it is becoming increasingly clear that it drives different cellular outcomes and is involved in the pathogenesis of V. vulnificus. This minireview outlines recent advances in our understanding of the regulation of vvhA gene expression, the biological activity of the VVH and its role in pathogenesis. An in-depth examination of the role of the VVH in V. vulnificus pathogenesis will help reveal the potential targets for therapeutic and preventive interventions to treat fatal V. vulnificus septicemia in humans. Future directions in VVH research will also be discussed. |
topic |
Vibrio vulnificus hemolysin (VVH) cholesterol-dependent cytolysin (CDC) biological activity gene regulation sepsis pathogenesis |
url |
https://www.frontiersin.org/articles/10.3389/fimmu.2020.599439/full |
work_keys_str_mv |
AT yuanyuan vibriovulnificushemolysinbiologicalactivityregulationofvvhaexpressionandroleinpathogenesis AT zihanfeng vibriovulnificushemolysinbiologicalactivityregulationofvvhaexpressionandroleinpathogenesis AT jinglinwang vibriovulnificushemolysinbiologicalactivityregulationofvvhaexpressionandroleinpathogenesis |
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1724481101361053696 |