Azathioprine-Induced Acute Submandibular Sialadenitis in a Crohn’s Disease Patient
Introduction: Azathioprine (AZA) is a widely used immunosuppressive drug in inflammatory bowel disease (IBD). The occurrence of adverse effects (AEs) is a major downside in the use of this drug, leading to treatment withdrawal in a variable proportion of patients. Case Presentation: We report the ca...
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doaj-95bb195ddfba44e699aa504fc731eed12020-11-25T03:58:34ZengKarger PublishersGE: Portuguese Journal of Gastroenterology2341-45452387-19542020-01-011310.1159/000505037505037Azathioprine-Induced Acute Submandibular Sialadenitis in a Crohn’s Disease PatientJoana Inês Alves da SilvaCidalina CaetanoIsabel PedrotoIntroduction: Azathioprine (AZA) is a widely used immunosuppressive drug in inflammatory bowel disease (IBD). The occurrence of adverse effects (AEs) is a major downside in the use of this drug, leading to treatment withdrawal in a variable proportion of patients. Case Presentation: We report the case of a Crohn’s disease patient who developed sialadenitis as an AE to AZA. Discussion and Conclusion: To our knowledge this AE has been reported only once in the literature. Sialadenitis is a common disorder and refers to inflammation of a salivary gland. It has many causes, such as bacterial and viral infections, ductal obstruction, and drugs. There are several AEs related to this drug, categorized as dose-dependent and dose-independent. Their knowledge is essential for therapeutic management in IBD, which is already challenging, requiring an individualized approach.https://www.karger.com/Article/FullText/505037azathioprineadverse effectsialadenitiscrohn’s disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Joana Inês Alves da Silva Cidalina Caetano Isabel Pedroto |
spellingShingle |
Joana Inês Alves da Silva Cidalina Caetano Isabel Pedroto Azathioprine-Induced Acute Submandibular Sialadenitis in a Crohn’s Disease Patient GE: Portuguese Journal of Gastroenterology azathioprine adverse effect sialadenitis crohn’s disease |
author_facet |
Joana Inês Alves da Silva Cidalina Caetano Isabel Pedroto |
author_sort |
Joana Inês Alves da Silva |
title |
Azathioprine-Induced Acute Submandibular Sialadenitis in a Crohn’s Disease Patient |
title_short |
Azathioprine-Induced Acute Submandibular Sialadenitis in a Crohn’s Disease Patient |
title_full |
Azathioprine-Induced Acute Submandibular Sialadenitis in a Crohn’s Disease Patient |
title_fullStr |
Azathioprine-Induced Acute Submandibular Sialadenitis in a Crohn’s Disease Patient |
title_full_unstemmed |
Azathioprine-Induced Acute Submandibular Sialadenitis in a Crohn’s Disease Patient |
title_sort |
azathioprine-induced acute submandibular sialadenitis in a crohn’s disease patient |
publisher |
Karger Publishers |
series |
GE: Portuguese Journal of Gastroenterology |
issn |
2341-4545 2387-1954 |
publishDate |
2020-01-01 |
description |
Introduction: Azathioprine (AZA) is a widely used immunosuppressive drug in inflammatory bowel disease (IBD). The occurrence of adverse effects (AEs) is a major downside in the use of this drug, leading to treatment withdrawal in a variable proportion of patients. Case Presentation: We report the case of a Crohn’s disease patient who developed sialadenitis as an AE to AZA. Discussion and Conclusion: To our knowledge this AE has been reported only once in the literature. Sialadenitis is a common disorder and refers to inflammation of a salivary gland. It has many causes, such as bacterial and viral infections, ductal obstruction, and drugs. There are several AEs related to this drug, categorized as dose-dependent and dose-independent. Their knowledge is essential for therapeutic management in IBD, which is already challenging, requiring an individualized approach. |
topic |
azathioprine adverse effect sialadenitis crohn’s disease |
url |
https://www.karger.com/Article/FullText/505037 |
work_keys_str_mv |
AT joanainesalvesdasilva azathioprineinducedacutesubmandibularsialadenitisinacrohnsdiseasepatient AT cidalinacaetano azathioprineinducedacutesubmandibularsialadenitisinacrohnsdiseasepatient AT isabelpedroto azathioprineinducedacutesubmandibularsialadenitisinacrohnsdiseasepatient |
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