Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity

Programmed Death ligand-1 (PD-L1) protein mediates immune suppression in cancer. Here, the authors show that in breast cancer, PD-L1 expression can be up regulated post-translationally by glycosylation, which in turn acts through inhibiting GSK3β-mediated PD-L1 degradation.

Bibliographic Details
Main Authors:	Chia-Wei Li, Seung-Oe Lim, Weiya Xia, Heng-Huan Lee, Li-Chuan Chan, Chu-Wei Kuo, Kay-Hooi Khoo, Shih-Shin Chang, Jong-Ho Cha, Taewan Kim, Jennifer L. Hsu, Yun Wu, Jung-Mao Hsu, Hirohito Yamaguchi, Qingqing Ding, Yan Wang, Jun Yao, Cheng-Chung Lee, Hsing-Ju Wu, Aysegul A. Sahin, James P. Allison, Dihua Yu, Gabriel N. Hortobagyi, Mien-Chie Hung
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms12632

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spelling	doaj-95bbbbb825d74f9a9d75ce9718db0cfa2021-05-11T10:42:22ZengNature Publishing GroupNature Communications2041-17232016-08-017111110.1038/ncomms12632Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activityChia-Wei Li0Seung-Oe Lim1Weiya Xia2Heng-Huan Lee3Li-Chuan Chan4Chu-Wei Kuo5Kay-Hooi Khoo6Shih-Shin Chang7Jong-Ho Cha8Taewan Kim9Jennifer L. Hsu10Yun Wu11Jung-Mao Hsu12Hirohito Yamaguchi13Qingqing Ding14Yan Wang15Jun Yao16Cheng-Chung Lee17Hsing-Ju Wu18Aysegul A. Sahin19James P. Allison20Dihua Yu21Gabriel N. Hortobagyi22Mien-Chie Hung23Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterCore Facilities for Protein Structural Analysis, Academia SinicaInstitute of Biological Chemistry, Academia SinicaDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Pathology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterCore Facilities for Protein Structural Analysis, Academia SinicaCenter for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical UniversityDepartment of Pathology, The University of Texas MD Anderson Cancer CenterDepartment of Immunology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Breast Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterProgrammed Death ligand-1 (PD-L1) protein mediates immune suppression in cancer. Here, the authors show that in breast cancer, PD-L1 expression can be up regulated post-translationally by glycosylation, which in turn acts through inhibiting GSK3β-mediated PD-L1 degradation.https://doi.org/10.1038/ncomms12632
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Chia-Wei Li Seung-Oe Lim Weiya Xia Heng-Huan Lee Li-Chuan Chan Chu-Wei Kuo Kay-Hooi Khoo Shih-Shin Chang Jong-Ho Cha Taewan Kim Jennifer L. Hsu Yun Wu Jung-Mao Hsu Hirohito Yamaguchi Qingqing Ding Yan Wang Jun Yao Cheng-Chung Lee Hsing-Ju Wu Aysegul A. Sahin James P. Allison Dihua Yu Gabriel N. Hortobagyi Mien-Chie Hung
spellingShingle	Chia-Wei Li Seung-Oe Lim Weiya Xia Heng-Huan Lee Li-Chuan Chan Chu-Wei Kuo Kay-Hooi Khoo Shih-Shin Chang Jong-Ho Cha Taewan Kim Jennifer L. Hsu Yun Wu Jung-Mao Hsu Hirohito Yamaguchi Qingqing Ding Yan Wang Jun Yao Cheng-Chung Lee Hsing-Ju Wu Aysegul A. Sahin James P. Allison Dihua Yu Gabriel N. Hortobagyi Mien-Chie Hung Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity Nature Communications
author_facet	Chia-Wei Li Seung-Oe Lim Weiya Xia Heng-Huan Lee Li-Chuan Chan Chu-Wei Kuo Kay-Hooi Khoo Shih-Shin Chang Jong-Ho Cha Taewan Kim Jennifer L. Hsu Yun Wu Jung-Mao Hsu Hirohito Yamaguchi Qingqing Ding Yan Wang Jun Yao Cheng-Chung Lee Hsing-Ju Wu Aysegul A. Sahin James P. Allison Dihua Yu Gabriel N. Hortobagyi Mien-Chie Hung
author_sort	Chia-Wei Li
title	Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
title_short	Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
title_full	Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
title_fullStr	Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
title_full_unstemmed	Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
title_sort	glycosylation and stabilization of programmed death ligand-1 suppresses t-cell activity
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-08-01
description	Programmed Death ligand-1 (PD-L1) protein mediates immune suppression in cancer. Here, the authors show that in breast cancer, PD-L1 expression can be up regulated post-translationally by glycosylation, which in turn acts through inhibiting GSK3β-mediated PD-L1 degradation.
url	https://doi.org/10.1038/ncomms12632
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Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity

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