Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
Programmed Death ligand-1 (PD-L1) protein mediates immune suppression in cancer. Here, the authors show that in breast cancer, PD-L1 expression can be up regulated post-translationally by glycosylation, which in turn acts through inhibiting GSK3β-mediated PD-L1 degradation.
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2016-08-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms12632 |
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doaj-95bbbbb825d74f9a9d75ce9718db0cfa2021-05-11T10:42:22ZengNature Publishing GroupNature Communications2041-17232016-08-017111110.1038/ncomms12632Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activityChia-Wei Li0Seung-Oe Lim1Weiya Xia2Heng-Huan Lee3Li-Chuan Chan4Chu-Wei Kuo5Kay-Hooi Khoo6Shih-Shin Chang7Jong-Ho Cha8Taewan Kim9Jennifer L. Hsu10Yun Wu11Jung-Mao Hsu12Hirohito Yamaguchi13Qingqing Ding14Yan Wang15Jun Yao16Cheng-Chung Lee17Hsing-Ju Wu18Aysegul A. Sahin19James P. Allison20Dihua Yu21Gabriel N. Hortobagyi22Mien-Chie Hung23Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterCore Facilities for Protein Structural Analysis, Academia SinicaInstitute of Biological Chemistry, Academia SinicaDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Pathology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterCore Facilities for Protein Structural Analysis, Academia SinicaCenter for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical UniversityDepartment of Pathology, The University of Texas MD Anderson Cancer CenterDepartment of Immunology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Breast Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterProgrammed Death ligand-1 (PD-L1) protein mediates immune suppression in cancer. Here, the authors show that in breast cancer, PD-L1 expression can be up regulated post-translationally by glycosylation, which in turn acts through inhibiting GSK3β-mediated PD-L1 degradation.https://doi.org/10.1038/ncomms12632 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chia-Wei Li Seung-Oe Lim Weiya Xia Heng-Huan Lee Li-Chuan Chan Chu-Wei Kuo Kay-Hooi Khoo Shih-Shin Chang Jong-Ho Cha Taewan Kim Jennifer L. Hsu Yun Wu Jung-Mao Hsu Hirohito Yamaguchi Qingqing Ding Yan Wang Jun Yao Cheng-Chung Lee Hsing-Ju Wu Aysegul A. Sahin James P. Allison Dihua Yu Gabriel N. Hortobagyi Mien-Chie Hung |
spellingShingle |
Chia-Wei Li Seung-Oe Lim Weiya Xia Heng-Huan Lee Li-Chuan Chan Chu-Wei Kuo Kay-Hooi Khoo Shih-Shin Chang Jong-Ho Cha Taewan Kim Jennifer L. Hsu Yun Wu Jung-Mao Hsu Hirohito Yamaguchi Qingqing Ding Yan Wang Jun Yao Cheng-Chung Lee Hsing-Ju Wu Aysegul A. Sahin James P. Allison Dihua Yu Gabriel N. Hortobagyi Mien-Chie Hung Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity Nature Communications |
author_facet |
Chia-Wei Li Seung-Oe Lim Weiya Xia Heng-Huan Lee Li-Chuan Chan Chu-Wei Kuo Kay-Hooi Khoo Shih-Shin Chang Jong-Ho Cha Taewan Kim Jennifer L. Hsu Yun Wu Jung-Mao Hsu Hirohito Yamaguchi Qingqing Ding Yan Wang Jun Yao Cheng-Chung Lee Hsing-Ju Wu Aysegul A. Sahin James P. Allison Dihua Yu Gabriel N. Hortobagyi Mien-Chie Hung |
author_sort |
Chia-Wei Li |
title |
Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity |
title_short |
Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity |
title_full |
Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity |
title_fullStr |
Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity |
title_full_unstemmed |
Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity |
title_sort |
glycosylation and stabilization of programmed death ligand-1 suppresses t-cell activity |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2016-08-01 |
description |
Programmed Death ligand-1 (PD-L1) protein mediates immune suppression in cancer. Here, the authors show that in breast cancer, PD-L1 expression can be up regulated post-translationally by glycosylation, which in turn acts through inhibiting GSK3β-mediated PD-L1 degradation. |
url |
https://doi.org/10.1038/ncomms12632 |
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