Frequency and coexistence of recurrent chromosomal aberrations in multiple myeloma patients

• Main Authors: Katarina Reberšek, Peter Černelč, Helena Podgornik
• Format: Article
• Language: English
• Published: Slovenian Medical Association 2010-11-01
• Series: Zdravniški Vestnik
• Online Access: http://vestnik.szd.si/index.php/ZdravVest/article/view/317
• ISSN: 1318-0347; 1581-0224

Background: The genome of myeloma plasma cells is characterized by marked instability comprising both complex numeric and structural abnormalities. Recent data in the literature suggest that multiple myeloma (MM) is also associated with deletion of 1p, amplification of 1q, deletion of 6q and amplification of 15q. These chromosomal aberrations have an impact on MM prognosis. We have looked for above mentioned chromosomal abnormalities in 68 newly diagnosed MM patients. Furthermore, our aim was to establish whether certain chromosomal abnormalities occur together with the others or exclusively autonomously. Methods: Chromosomal aberrations were detected using commercially available FISH DNA probes. Results: Deletion of 1p, amplification of 1q, deletion of 6q and amplification of 15q were present in 10 %, 40 %, 10 % and 47 % of patients, respectively. Our results confirm that amplification of 1q and del(13)(q14.3) are highly associated. We also detected an association between amplification of 1q and t(4;14)(p16.3;q32), and del(17)(p13.1). Additionally, the association between amplification of 15q and del(17)(p13.1), and del(6q) was statistically confirmed. Conclusions: Literature data confirm the prognostic significance of newly tested chromosomal abnormalities in MM patients. Since they are frequent in our group of MM patients, the addition of DNA-probes into MM FISH probe panel has a substantial meaning for their detection .