Synthesis of New C2-Symmetric Six-Membered NHCs and Their Application for the Asymmetric Diethylzinc Addition of Arylaldehydes

A concise method for the preparation of new 3,4,5,6-tetrahydropyrimidinium salts was presented in this paper. Further application of these salts in asymmetric diethylzinc addition of arylaldehydes was explored, giving the corresponding chiral second alcohols in good yields and moderate enantioselect...

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Main Authors:	Jie Li, Bihui Zhou, Yajie Jiang, Xiaoming Liu
Format:	Article
Language:	English
Published:	MDPI AG 2018-01-01
Series:	Catalysts
Subjects:	N-heterocyclic carbene tetrahydropyrimidinium enantioselectivity asymmetric addition chiral secondary alcohols
Online Access:	http://www.mdpi.com/2073-4344/8/2/46

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spelling	doaj-95c49e86d0944adf9a198fe45e5299de2020-11-24T23:12:18ZengMDPI AGCatalysts2073-43442018-01-01824610.3390/catal8020046catal8020046Synthesis of New C2-Symmetric Six-Membered NHCs and Their Application for the Asymmetric Diethylzinc Addition of ArylaldehydesJie Li0Bihui Zhou1Yajie Jiang2Xiaoming Liu3School of Medicine, Zhejiang University City College, No. 48, Huzhou Road, Hangzhou 310015, ChinaSchool of Medicine, Zhejiang University City College, No. 48, Huzhou Road, Hangzhou 310015, ChinaSchool of Medicine, Zhejiang University City College, No. 48, Huzhou Road, Hangzhou 310015, ChinaDepartment of Dermatologry, The Third Affiliated Hospital of Soochow University, No. 185, Juqian Street, Changzhou 213000, ChinaA concise method for the preparation of new 3,4,5,6-tetrahydropyrimidinium salts was presented in this paper. Further application of these salts in asymmetric diethylzinc addition of arylaldehydes was explored, giving the corresponding chiral second alcohols in good yields and moderate enantioselectivities.http://www.mdpi.com/2073-4344/8/2/46N-heterocyclic carbenetetrahydropyrimidiniumenantioselectivityasymmetric additionchiral secondary alcohols
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jie Li Bihui Zhou Yajie Jiang Xiaoming Liu
spellingShingle	Jie Li Bihui Zhou Yajie Jiang Xiaoming Liu Synthesis of New C2-Symmetric Six-Membered NHCs and Their Application for the Asymmetric Diethylzinc Addition of Arylaldehydes Catalysts N-heterocyclic carbene tetrahydropyrimidinium enantioselectivity asymmetric addition chiral secondary alcohols
author_facet	Jie Li Bihui Zhou Yajie Jiang Xiaoming Liu
author_sort	Jie Li
title	Synthesis of New C2-Symmetric Six-Membered NHCs and Their Application for the Asymmetric Diethylzinc Addition of Arylaldehydes
title_short	Synthesis of New C2-Symmetric Six-Membered NHCs and Their Application for the Asymmetric Diethylzinc Addition of Arylaldehydes
title_full	Synthesis of New C2-Symmetric Six-Membered NHCs and Their Application for the Asymmetric Diethylzinc Addition of Arylaldehydes
title_fullStr	Synthesis of New C2-Symmetric Six-Membered NHCs and Their Application for the Asymmetric Diethylzinc Addition of Arylaldehydes
title_full_unstemmed	Synthesis of New C2-Symmetric Six-Membered NHCs and Their Application for the Asymmetric Diethylzinc Addition of Arylaldehydes
title_sort	synthesis of new c2-symmetric six-membered nhcs and their application for the asymmetric diethylzinc addition of arylaldehydes
publisher	MDPI AG
series	Catalysts
issn	2073-4344
publishDate	2018-01-01
description	A concise method for the preparation of new 3,4,5,6-tetrahydropyrimidinium salts was presented in this paper. Further application of these salts in asymmetric diethylzinc addition of arylaldehydes was explored, giving the corresponding chiral second alcohols in good yields and moderate enantioselectivities.
topic	N-heterocyclic carbene tetrahydropyrimidinium enantioselectivity asymmetric addition chiral secondary alcohols
url	http://www.mdpi.com/2073-4344/8/2/46
work_keys_str_mv	AT jieli synthesisofnewc2symmetricsixmemberednhcsandtheirapplicationfortheasymmetricdiethylzincadditionofarylaldehydes AT bihuizhou synthesisofnewc2symmetricsixmemberednhcsandtheirapplicationfortheasymmetricdiethylzincadditionofarylaldehydes AT yajiejiang synthesisofnewc2symmetricsixmemberednhcsandtheirapplicationfortheasymmetricdiethylzincadditionofarylaldehydes AT xiaomingliu synthesisofnewc2symmetricsixmemberednhcsandtheirapplicationfortheasymmetricdiethylzincadditionofarylaldehydes
_version_	1725601525989900288

Synthesis of New C2-Symmetric Six-Membered NHCs and Their Application for the Asymmetric Diethylzinc Addition of Arylaldehydes

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