Distinct Ultradian Rhythms in Plasma Clusterin Concentrations in Lean and Obese Korean Subjects
BackgroundBlood levels of many hormones show rhythmic fluctuations with variable duration of cycles. Clusterin/apolipoprotein J is a glycoprotein which is highly expressed in the plasma and has modulatory roles in immune and inflammatory reactions, neurobiology, lipid metabolism, and leptin signalin...
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doaj-95d3a12a5eca4e46a2810e2a38464e3c2020-11-24T20:48:24ZengAcademya Publishing Co.Endocrinology and Metabolism2093-596X2093-59782018-05-0133224525110.3803/EnM.2018.33.2.245Distinct Ultradian Rhythms in Plasma Clusterin Concentrations in Lean and Obese Korean SubjectsJong Han Choi0Eunheui Jeong1Byung Soo Youn2Min-Seon Kim3Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, .KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Veterans Health Service Medical Center, Seoul, .KoreaOsteoneurogen Inc., Seoul, .KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, .KoreaBackgroundBlood levels of many hormones show rhythmic fluctuations with variable duration of cycles. Clusterin/apolipoprotein J is a glycoprotein which is highly expressed in the plasma and has modulatory roles in immune and inflammatory reactions, neurobiology, lipid metabolism, and leptin signaling. In this study, we examined the diurnal fluctuations of plasma clusterin concentrations in lean and obese young men.MethodsFor the study, 14 subjects (five lean and five obese men; two lean and two obese women) were admitted to the research ward and blood samples were drawn every 30 minutes during light-on period (6:00 AM to 10:00 PM) and every hour during light-off period.ResultsNotably, plasma clusterin concentrations displayed a unique ultradian rhythm with five cycles a day in both men and women. During the light-on period, circulating clusterin levels showed fluctuating curves with 4 hours regular intervals with sharp peaks and troughs. In contrast, single oscillation curve during light-off exhibited a smoothened/lower peak and longer (8-hour) duration. In obese men, these cycles were phase-advanced by approximately 1 hour, and had reduced amplitude of fluctuating curves and blunted diurnal pattern. Cyclic fluctuations of plasma clusterin were preserved under fasting and unexpected meal condition, suggesting that rhythmic oscillations in plasma clusterin levels are not generated by meal-related cues.ConclusionThese findings firstly demonstrate a novel pattern of plasma clusterin fluctuations with extremely regular cycles.https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-33-245.pdfClusterinObesityUltradian rhythmCircadian rhythm |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jong Han Choi Eunheui Jeong Byung Soo Youn Min-Seon Kim |
spellingShingle |
Jong Han Choi Eunheui Jeong Byung Soo Youn Min-Seon Kim Distinct Ultradian Rhythms in Plasma Clusterin Concentrations in Lean and Obese Korean Subjects Endocrinology and Metabolism Clusterin Obesity Ultradian rhythm Circadian rhythm |
author_facet |
Jong Han Choi Eunheui Jeong Byung Soo Youn Min-Seon Kim |
author_sort |
Jong Han Choi |
title |
Distinct Ultradian Rhythms in Plasma Clusterin Concentrations in Lean and Obese Korean Subjects |
title_short |
Distinct Ultradian Rhythms in Plasma Clusterin Concentrations in Lean and Obese Korean Subjects |
title_full |
Distinct Ultradian Rhythms in Plasma Clusterin Concentrations in Lean and Obese Korean Subjects |
title_fullStr |
Distinct Ultradian Rhythms in Plasma Clusterin Concentrations in Lean and Obese Korean Subjects |
title_full_unstemmed |
Distinct Ultradian Rhythms in Plasma Clusterin Concentrations in Lean and Obese Korean Subjects |
title_sort |
distinct ultradian rhythms in plasma clusterin concentrations in lean and obese korean subjects |
publisher |
Academya Publishing Co. |
series |
Endocrinology and Metabolism |
issn |
2093-596X 2093-5978 |
publishDate |
2018-05-01 |
description |
BackgroundBlood levels of many hormones show rhythmic fluctuations with variable duration of cycles. Clusterin/apolipoprotein J is a glycoprotein which is highly expressed in the plasma and has modulatory roles in immune and inflammatory reactions, neurobiology, lipid metabolism, and leptin signaling. In this study, we examined the diurnal fluctuations of plasma clusterin concentrations in lean and obese young men.MethodsFor the study, 14 subjects (five lean and five obese men; two lean and two obese women) were admitted to the research ward and blood samples were drawn every 30 minutes during light-on period (6:00 AM to 10:00 PM) and every hour during light-off period.ResultsNotably, plasma clusterin concentrations displayed a unique ultradian rhythm with five cycles a day in both men and women. During the light-on period, circulating clusterin levels showed fluctuating curves with 4 hours regular intervals with sharp peaks and troughs. In contrast, single oscillation curve during light-off exhibited a smoothened/lower peak and longer (8-hour) duration. In obese men, these cycles were phase-advanced by approximately 1 hour, and had reduced amplitude of fluctuating curves and blunted diurnal pattern. Cyclic fluctuations of plasma clusterin were preserved under fasting and unexpected meal condition, suggesting that rhythmic oscillations in plasma clusterin levels are not generated by meal-related cues.ConclusionThese findings firstly demonstrate a novel pattern of plasma clusterin fluctuations with extremely regular cycles. |
topic |
Clusterin Obesity Ultradian rhythm Circadian rhythm |
url |
https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-33-245.pdf |
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