Preparation, Characterization, and Stability Evaluation of Taste-Masking Lacosamide Microparticles

Preparation, Characterization, and Stability Evaluation of Taste-Masking Lacosamide Microparticles

Lacosamide (LCM) is a third-generation antiepileptic drug. Selective action of the drug on voltage-gated sodium channels reduces side effects. Oral administration of LCM shows good pharmacokinetic profile. However, the bitter taste of LCM is a barrier to the development of oral formulations. In this...

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Bibliographic Details
Main Authors: Chang-Soo Han, Seungsu Kim, Dong-Won Oh, Jeong Yeol Yoon, Eun-Seok Park, Yun-Seok Rhee, Ju-Young Kim, Dae Hwan Shin, Dong-Wook Kim, Chun-Woong Park
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Materials
Subjects:
pH dependent
encapsulation
taste-masking effectiveness
surface enrichment
recrystallization
Online Access:https://www.mdpi.com/1996-1944/12/6/1000

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