Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses

The Lpp lipoproteins of staphylococci trigger a TLR2-dependent immune response. Here, the authors show that commensal species (S. aureus, S. epidermidis) induce a less-intense TLR2 response than non-commensal species (S. carnosus) due to differential modification of the Lpp lipid moieties.

Bibliographic Details
Main Authors:	Minh-Thu Nguyen, Julia Uebele, Nimerta Kumari, Hiroshi Nakayama, Lena Peter, Olga Ticha, Anne-Kathrin Woischnig, Mathias Schmaler, Nina Khanna, Naoshi Dohmae, Bok Luel Lee, Isabelle Bekeredjian-Ding, Friedrich Götz
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-12-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-02234-4

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spelling	doaj-95d81711f93f4c8c8fb6d6efe4302cb22021-01-31T12:44:09ZengNature Publishing GroupNature Communications2041-17232017-12-018111210.1038/s41467-017-02234-4Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responsesMinh-Thu Nguyen0Julia Uebele1Nimerta Kumari2Hiroshi Nakayama3Lena Peter4Olga Ticha5Anne-Kathrin Woischnig6Mathias Schmaler7Nina Khanna8Naoshi Dohmae9Bok Luel Lee10Isabelle Bekeredjian-Ding11Friedrich Götz12Microbial Genetics, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), University of TübingenPaul-Ehrlich-Institute, Federal Regulatory Agency for Vaccines and BiomedicinesMicrobial Genetics, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), University of TübingenBiomolecular Characterization Unit, RIKEN Center for Sustainable Resource SciencePaul-Ehrlich-Institute, Federal Regulatory Agency for Vaccines and BiomedicinesPaul-Ehrlich-Institute, Federal Regulatory Agency for Vaccines and BiomedicinesLaboratory of Infection Biology, Department of Biomedicine, University Hospital BaselLaboratory of Infection Biology, Department of Biomedicine, University Hospital BaselLaboratory of Infection Biology, Department of Biomedicine, University Hospital BaselBiomolecular Characterization Unit, RIKEN Center for Sustainable Resource ScienceNational Research Laboratory of Defense Proteins, College of Pharmacy, Pusan National UniversityPaul-Ehrlich-Institute, Federal Regulatory Agency for Vaccines and BiomedicinesMicrobial Genetics, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), University of TübingenThe Lpp lipoproteins of staphylococci trigger a TLR2-dependent immune response. Here, the authors show that commensal species (S. aureus, S. epidermidis) induce a less-intense TLR2 response than non-commensal species (S. carnosus) due to differential modification of the Lpp lipid moieties.https://doi.org/10.1038/s41467-017-02234-4
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Minh-Thu Nguyen Julia Uebele Nimerta Kumari Hiroshi Nakayama Lena Peter Olga Ticha Anne-Kathrin Woischnig Mathias Schmaler Nina Khanna Naoshi Dohmae Bok Luel Lee Isabelle Bekeredjian-Ding Friedrich Götz
spellingShingle	Minh-Thu Nguyen Julia Uebele Nimerta Kumari Hiroshi Nakayama Lena Peter Olga Ticha Anne-Kathrin Woischnig Mathias Schmaler Nina Khanna Naoshi Dohmae Bok Luel Lee Isabelle Bekeredjian-Ding Friedrich Götz Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses Nature Communications
author_facet	Minh-Thu Nguyen Julia Uebele Nimerta Kumari Hiroshi Nakayama Lena Peter Olga Ticha Anne-Kathrin Woischnig Mathias Schmaler Nina Khanna Naoshi Dohmae Bok Luel Lee Isabelle Bekeredjian-Ding Friedrich Götz
author_sort	Minh-Thu Nguyen
title	Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses
title_short	Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses
title_full	Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses
title_fullStr	Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses
title_full_unstemmed	Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses
title_sort	lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-12-01
description	The Lpp lipoproteins of staphylococci trigger a TLR2-dependent immune response. Here, the authors show that commensal species (S. aureus, S. epidermidis) induce a less-intense TLR2 response than non-commensal species (S. carnosus) due to differential modification of the Lpp lipid moieties.
url	https://doi.org/10.1038/s41467-017-02234-4
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Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses

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