Variant-specific inflation factors for assessing population stratification at the phenotypic variance level
Pooling participant-level genetic data into a single analysis can result in variance stratification, reducing statistical performance. Here, the authors develop variant-specific inflation factors to assess variance stratification and apply this to pooled individual-level data from whole genome seque...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-23655-2 |
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doaj-95ef2a1716c643edaaee9314353151642021-06-13T11:15:20ZengNature Publishing GroupNature Communications2041-17232021-06-0112111410.1038/s41467-021-23655-2Variant-specific inflation factors for assessing population stratification at the phenotypic variance levelTamar Sofer0Xiuwen Zheng1Cecelia A. Laurie2Stephanie M. Gogarten3Jennifer A. Brody4Matthew P. Conomos5Joshua C. Bis6Timothy A. Thornton7Adam Szpiro8Jeffrey R. O’Connell9Ethan M. Lange10Yan Gao11L. Adrienne Cupples12Bruce M. Psaty13NHLBI Trans-Omics for Precision Medicine (TOPMed) ConsortiumKenneth M. Rice14Division of Sleep and Circadian Disorders, Brigham and Women’s HospitalDepartment of Biostatistics, University of WashingtonDepartment of Biostatistics, University of WashingtonDepartment of Biostatistics, University of WashingtonCardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of WashingtonDepartment of Biostatistics, University of WashingtonDepartment of Biostatistics, University of WashingtonDepartment of Biostatistics, University of WashingtonDepartment of Biostatistics, University of WashingtonDepartment of Medicine, Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of MedicineDepartment of Medicine, University of Colorado Anschutz Medical CampusSchool of Medicine, University Mississippi Medical CenterDepartment of Biostatistics, Boston University School of Public HealthCardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of WashingtonDepartment of Biostatistics, University of WashingtonPooling participant-level genetic data into a single analysis can result in variance stratification, reducing statistical performance. Here, the authors develop variant-specific inflation factors to assess variance stratification and apply this to pooled individual-level data from whole genome sequencing.https://doi.org/10.1038/s41467-021-23655-2 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Tamar Sofer Xiuwen Zheng Cecelia A. Laurie Stephanie M. Gogarten Jennifer A. Brody Matthew P. Conomos Joshua C. Bis Timothy A. Thornton Adam Szpiro Jeffrey R. O’Connell Ethan M. Lange Yan Gao L. Adrienne Cupples Bruce M. Psaty NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium Kenneth M. Rice |
| spellingShingle |
Tamar Sofer Xiuwen Zheng Cecelia A. Laurie Stephanie M. Gogarten Jennifer A. Brody Matthew P. Conomos Joshua C. Bis Timothy A. Thornton Adam Szpiro Jeffrey R. O’Connell Ethan M. Lange Yan Gao L. Adrienne Cupples Bruce M. Psaty NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium Kenneth M. Rice Variant-specific inflation factors for assessing population stratification at the phenotypic variance level Nature Communications |
| author_facet |
Tamar Sofer Xiuwen Zheng Cecelia A. Laurie Stephanie M. Gogarten Jennifer A. Brody Matthew P. Conomos Joshua C. Bis Timothy A. Thornton Adam Szpiro Jeffrey R. O’Connell Ethan M. Lange Yan Gao L. Adrienne Cupples Bruce M. Psaty NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium Kenneth M. Rice |
| author_sort |
Tamar Sofer |
| title |
Variant-specific inflation factors for assessing population stratification at the phenotypic variance level |
| title_short |
Variant-specific inflation factors for assessing population stratification at the phenotypic variance level |
| title_full |
Variant-specific inflation factors for assessing population stratification at the phenotypic variance level |
| title_fullStr |
Variant-specific inflation factors for assessing population stratification at the phenotypic variance level |
| title_full_unstemmed |
Variant-specific inflation factors for assessing population stratification at the phenotypic variance level |
| title_sort |
variant-specific inflation factors for assessing population stratification at the phenotypic variance level |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-06-01 |
| description |
Pooling participant-level genetic data into a single analysis can result in variance stratification, reducing statistical performance. Here, the authors develop variant-specific inflation factors to assess variance stratification and apply this to pooled individual-level data from whole genome sequencing. |
| url |
https://doi.org/10.1038/s41467-021-23655-2 |
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