Mammalian chromosome–telomere length dynamics
Individual chromosome arms have specific individual telomere lengths (TLs). Past studies within species have shown strong positive correlations between individual chromosome length and TL at that chromosome. While the reasons for these associations are unclear, the strength and consistency of the as...
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2018-01-01
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Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.180492 |
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doaj-95ef2a3c8e574a50959566ebe34ece5d2020-11-25T04:00:19ZengThe Royal SocietyRoyal Society Open Science2054-57032018-01-015710.1098/rsos.180492180492Mammalian chromosome–telomere length dynamicsAmy R. KlegarthDan T. A. EisenbergIndividual chromosome arms have specific individual telomere lengths (TLs). Past studies within species have shown strong positive correlations between individual chromosome length and TL at that chromosome. While the reasons for these associations are unclear, the strength and consistency of the associations across disparate taxa suggest that this is important to telomere biology and should be explored further. If TL is primarily determined by chromosome length, then chromosome length should be considered and controlled for in cross-species analyses of TL. Here, we employ a cross-species approach to explore whether the chromosome length–TL association observed intraspecifically is a determinant of mean TL across species. Data were compiled from two studies characterizing TL across a range of mammalian taxa and analysed in a phylogenetic framework. We found no significant relationship between TL and chromosome size across mammals or within mammalians orders. The pattern trends in the expected direction and we suggest may be masked by evolutionary lag effects.https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.180492telomere lengthmammalschromosome sizegenome sizec-valueevolutionary lag |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Amy R. Klegarth Dan T. A. Eisenberg |
spellingShingle |
Amy R. Klegarth Dan T. A. Eisenberg Mammalian chromosome–telomere length dynamics Royal Society Open Science telomere length mammals chromosome size genome size c-value evolutionary lag |
author_facet |
Amy R. Klegarth Dan T. A. Eisenberg |
author_sort |
Amy R. Klegarth |
title |
Mammalian chromosome–telomere length dynamics |
title_short |
Mammalian chromosome–telomere length dynamics |
title_full |
Mammalian chromosome–telomere length dynamics |
title_fullStr |
Mammalian chromosome–telomere length dynamics |
title_full_unstemmed |
Mammalian chromosome–telomere length dynamics |
title_sort |
mammalian chromosome–telomere length dynamics |
publisher |
The Royal Society |
series |
Royal Society Open Science |
issn |
2054-5703 |
publishDate |
2018-01-01 |
description |
Individual chromosome arms have specific individual telomere lengths (TLs). Past studies within species have shown strong positive correlations between individual chromosome length and TL at that chromosome. While the reasons for these associations are unclear, the strength and consistency of the associations across disparate taxa suggest that this is important to telomere biology and should be explored further. If TL is primarily determined by chromosome length, then chromosome length should be considered and controlled for in cross-species analyses of TL. Here, we employ a cross-species approach to explore whether the chromosome length–TL association observed intraspecifically is a determinant of mean TL across species. Data were compiled from two studies characterizing TL across a range of mammalian taxa and analysed in a phylogenetic framework. We found no significant relationship between TL and chromosome size across mammals or within mammalians orders. The pattern trends in the expected direction and we suggest may be masked by evolutionary lag effects. |
topic |
telomere length mammals chromosome size genome size c-value evolutionary lag |
url |
https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.180492 |
work_keys_str_mv |
AT amyrklegarth mammalianchromosometelomerelengthdynamics AT dantaeisenberg mammalianchromosometelomerelengthdynamics |
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1724451390841946112 |