“Driver-passenger” bacteria and their metabolites in the pathogenesis of colorectal cancer
Colorectal cancer (CRC) is a significant public health problem accounting for about 10% of all new cancer cases globally. Though genetic and epigenetic factors influence CRC, the gut microbiota acts as a significant component of the disease’s etiology. Further research is still needed to clarify the...
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2021-01-01
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Online Access: | http://dx.doi.org/10.1080/19490976.2021.1941710 |
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doaj-95f5a46bcdc74c50b8749fa29f0a7f4c2021-07-15T13:47:53ZengTaylor & Francis GroupGut Microbes1949-09761949-09842021-01-0113110.1080/19490976.2021.19417101941710“Driver-passenger” bacteria and their metabolites in the pathogenesis of colorectal cancerMarion Avril0R. William DePaolo1University of WashingtonUniversity of WashingtonColorectal cancer (CRC) is a significant public health problem accounting for about 10% of all new cancer cases globally. Though genetic and epigenetic factors influence CRC, the gut microbiota acts as a significant component of the disease’s etiology. Further research is still needed to clarify the specific roles and identify more bacteria related to CRC development. This review aims to provide an overview of the “driver-passenger” model of CRC. The colonization and active invasion of the “driver(s)” bacteria cause damages allowing other commensals, known as “passengers,” or their by-products, i.e., metabolites, to pass through the epithelium . This review will not only focus on the species of bacteria implicated in this model but also on their biological functions implicated in the occurrence of CRC, such as forming biofilms, mucus, penetration and production of enterotoxins and genotoxins.http://dx.doi.org/10.1080/19490976.2021.1941710colorectal cancermicrobiomedriver-passengermetabolitesmucusbiofilm |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marion Avril R. William DePaolo |
spellingShingle |
Marion Avril R. William DePaolo “Driver-passenger” bacteria and their metabolites in the pathogenesis of colorectal cancer Gut Microbes colorectal cancer microbiome driver-passenger metabolites mucus biofilm |
author_facet |
Marion Avril R. William DePaolo |
author_sort |
Marion Avril |
title |
“Driver-passenger” bacteria and their metabolites in the pathogenesis of colorectal cancer |
title_short |
“Driver-passenger” bacteria and their metabolites in the pathogenesis of colorectal cancer |
title_full |
“Driver-passenger” bacteria and their metabolites in the pathogenesis of colorectal cancer |
title_fullStr |
“Driver-passenger” bacteria and their metabolites in the pathogenesis of colorectal cancer |
title_full_unstemmed |
“Driver-passenger” bacteria and their metabolites in the pathogenesis of colorectal cancer |
title_sort |
“driver-passenger” bacteria and their metabolites in the pathogenesis of colorectal cancer |
publisher |
Taylor & Francis Group |
series |
Gut Microbes |
issn |
1949-0976 1949-0984 |
publishDate |
2021-01-01 |
description |
Colorectal cancer (CRC) is a significant public health problem accounting for about 10% of all new cancer cases globally. Though genetic and epigenetic factors influence CRC, the gut microbiota acts as a significant component of the disease’s etiology. Further research is still needed to clarify the specific roles and identify more bacteria related to CRC development. This review aims to provide an overview of the “driver-passenger” model of CRC. The colonization and active invasion of the “driver(s)” bacteria cause damages allowing other commensals, known as “passengers,” or their by-products, i.e., metabolites, to pass through the epithelium . This review will not only focus on the species of bacteria implicated in this model but also on their biological functions implicated in the occurrence of CRC, such as forming biofilms, mucus, penetration and production of enterotoxins and genotoxins. |
topic |
colorectal cancer microbiome driver-passenger metabolites mucus biofilm |
url |
http://dx.doi.org/10.1080/19490976.2021.1941710 |
work_keys_str_mv |
AT marionavril driverpassengerbacteriaandtheirmetabolitesinthepathogenesisofcolorectalcancer AT rwilliamdepaolo driverpassengerbacteriaandtheirmetabolitesinthepathogenesisofcolorectalcancer |
_version_ |
1721300700892233728 |