Genome-wide DNA methylation data from adult brain following prenatal immune activation and dietary intervention

Genome-wide DNA methylation data from adult brain following prenatal immune activation and dietary intervention

DNA methylation is a dynamic epigenetic mark regulating gene function and are implicated in the pathophysiology of schizophrenia and autism. Environmental exposures such as inflammation and diet modify the epigenome and may explain why prenatal exposure to inflammation increase risk of neurodevelopm...

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Main Authors: Paul Basil, Qi Li, Grainne M. McAlonan, Pak-Chung Sham
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Data in Brief
Online Access:http://www.sciencedirect.com/science/article/pii/S2352340919309163
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spelling doaj-9609733add64433fafd600d82f592b602020-11-25T00:07:11ZengElsevierData in Brief2352-34092019-10-0126Genome-wide DNA methylation data from adult brain following prenatal immune activation and dietary interventionPaul Basil0Qi Li1Grainne M. McAlonan2Pak-Chung Sham3Department of Psychiatry, The University of Hong Kong, Pok Fu Lam, Hong Kong Special Administrative Region of China; Department of Molecular & Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Corresponding author. Department of Molecular & Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.Department of Psychiatry, The University of Hong Kong, Pok Fu Lam, Hong Kong Special Administrative Region of ChinaDepartment of Psychiatry, The University of Hong Kong, Pok Fu Lam, Hong Kong Special Administrative Region of China; Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King's College London, De Crespigny Park, Denmark Hill, London, SE5 8AF, UKDepartment of Psychiatry, The University of Hong Kong, Pok Fu Lam, Hong Kong Special Administrative Region of China; State Key Laboratory of Brain and Cognitive Sciences and Centre for PanorOmicGenomic Sciences, The University of Hong Kong, Pok Fu Lam, Hong Kong Special Administrative Region of ChinaDNA methylation is a dynamic epigenetic mark regulating gene function and are implicated in the pathophysiology of schizophrenia and autism. Environmental exposures such as inflammation and diet modify the epigenome and may explain why prenatal exposure to inflammation increase risk of neurodevelopmental disorders. This manuscript presents genome-wide DNA methylation data (GSE102942) generated from adult offspring brain prenatally exposed to Maternal Immune Activation (MIA). Methylome of the adult brain supplemented with omega-3 polyunsaturated fatty acids (PUFA) is also described. DNA methylation across gene regulatory regions were measured using MSP-I digestion and Reduced Representation Bisulfite Sequencing (RRBS) method. Keywords: Epigenetics, PolyI:C, Methylation, Maternal immune activation, MSP-I, Reduced representation bisulfite sequencing (RRBS), Next generation sequencing (NGS)http://www.sciencedirect.com/science/article/pii/S2352340919309163
collection DOAJ
language English
format Article
sources DOAJ
author Paul Basil
Qi Li
Grainne M. McAlonan
Pak-Chung Sham
spellingShingle Paul Basil
Qi Li
Grainne M. McAlonan
Pak-Chung Sham
Genome-wide DNA methylation data from adult brain following prenatal immune activation and dietary intervention
Data in Brief
author_facet Paul Basil
Qi Li
Grainne M. McAlonan
Pak-Chung Sham
author_sort Paul Basil
title Genome-wide DNA methylation data from adult brain following prenatal immune activation and dietary intervention
title_short Genome-wide DNA methylation data from adult brain following prenatal immune activation and dietary intervention
title_full Genome-wide DNA methylation data from adult brain following prenatal immune activation and dietary intervention
title_fullStr Genome-wide DNA methylation data from adult brain following prenatal immune activation and dietary intervention
title_full_unstemmed Genome-wide DNA methylation data from adult brain following prenatal immune activation and dietary intervention
title_sort genome-wide dna methylation data from adult brain following prenatal immune activation and dietary intervention
publisher Elsevier
series Data in Brief
issn 2352-3409
publishDate 2019-10-01
description DNA methylation is a dynamic epigenetic mark regulating gene function and are implicated in the pathophysiology of schizophrenia and autism. Environmental exposures such as inflammation and diet modify the epigenome and may explain why prenatal exposure to inflammation increase risk of neurodevelopmental disorders. This manuscript presents genome-wide DNA methylation data (GSE102942) generated from adult offspring brain prenatally exposed to Maternal Immune Activation (MIA). Methylome of the adult brain supplemented with omega-3 polyunsaturated fatty acids (PUFA) is also described. DNA methylation across gene regulatory regions were measured using MSP-I digestion and Reduced Representation Bisulfite Sequencing (RRBS) method. Keywords: Epigenetics, PolyI:C, Methylation, Maternal immune activation, MSP-I, Reduced representation bisulfite sequencing (RRBS), Next generation sequencing (NGS)
url http://www.sciencedirect.com/science/article/pii/S2352340919309163
work_keys_str_mv AT paulbasil genomewidednamethylationdatafromadultbrainfollowingprenatalimmuneactivationanddietaryintervention
AT qili genomewidednamethylationdatafromadultbrainfollowingprenatalimmuneactivationanddietaryintervention
AT grainnemmcalonan genomewidednamethylationdatafromadultbrainfollowingprenatalimmuneactivationanddietaryintervention
AT pakchungsham genomewidednamethylationdatafromadultbrainfollowingprenatalimmuneactivationanddietaryintervention
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