The impact of extended adjuvant temozolomide in newly diagnosed glioblastoma multiforme: a meta-analysis and systematic review
Surgical resection followed by concurrent radiation therapy and temozolomide (TMZ) chemotherapy is the current standard treatment for glioblastoma multiforme (GBM). The present metaanalysis investigated the impact of prolonged TMZ maintenance therapy (more than 6 cycles) in comparison with standard...
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doaj-960eb0aec91f490499cc482f3d0aaada2020-11-25T03:10:01ZengPAGEPress PublicationsOncology Reviews1970-55571970-55652020-02-0114110.4081/oncol.2020.461The impact of extended adjuvant temozolomide in newly diagnosed glioblastoma multiforme: a meta-analysis and systematic reviewEhsan Alimohammadi0Seyed Reza Bagheri1Shahram Taheri2Maliheh Dayani3Alireza Abdi4Neurosurgery Department, Kermanshah University of Medical Sciences, KermanshahNeurosurgery Department, Kermanshah University of Medical Sciences, KermanshahNeurosurgery Department, Kermanshah University of Medical Sciences, KermanshahRadiooncology Department, Kermanshah University of Medical Sciences, KermanshahNursing and Midwifery School, Kermanshah University of Medical Sciences, Kermanshah Surgical resection followed by concurrent radiation therapy and temozolomide (TMZ) chemotherapy is the current standard treatment for glioblastoma multiforme (GBM). The present metaanalysis investigated the impact of prolonged TMZ maintenance therapy (more than 6 cycles) in comparison with standard TMZ maintenance therapy (exactly six cycles) on overall survival (OS) and progression-free survival (PFS) of patients with GBM. A meta-analysis of the literature was conducted using Medline, PubMed, EMBASE and the Cochrane Library in accordance with PRISMA guidelines. Seven articles involving 1018 patients were included. The overall survival was higher in the case group (>6 cycles TMZ) compared to the control group (6 cycles TMZ) (Z=2.375, P=0.018). The lower and upper limits were between 1.002-10.467 months. The case group had higher progression-free survival compared with the control group (Z=3.84; P<0.001). The lower and upper limits were between 2.559-7.894 months. Evidence from this meta-analysis suggests that prolonged TMZ therapy compared to the standard 6-cycle TMZ therapy was associated with higher survival in patients with glioblastoma. https://oncologyreviews.org/index.php/or/article/view/461Glioblastoma multiformemeta-analysisoverall survivalprogression free survivaltemozolomide. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ehsan Alimohammadi Seyed Reza Bagheri Shahram Taheri Maliheh Dayani Alireza Abdi |
spellingShingle |
Ehsan Alimohammadi Seyed Reza Bagheri Shahram Taheri Maliheh Dayani Alireza Abdi The impact of extended adjuvant temozolomide in newly diagnosed glioblastoma multiforme: a meta-analysis and systematic review Oncology Reviews Glioblastoma multiforme meta-analysis overall survival progression free survival temozolomide. |
author_facet |
Ehsan Alimohammadi Seyed Reza Bagheri Shahram Taheri Maliheh Dayani Alireza Abdi |
author_sort |
Ehsan Alimohammadi |
title |
The impact of extended adjuvant temozolomide in newly diagnosed glioblastoma multiforme: a meta-analysis and systematic review |
title_short |
The impact of extended adjuvant temozolomide in newly diagnosed glioblastoma multiforme: a meta-analysis and systematic review |
title_full |
The impact of extended adjuvant temozolomide in newly diagnosed glioblastoma multiforme: a meta-analysis and systematic review |
title_fullStr |
The impact of extended adjuvant temozolomide in newly diagnosed glioblastoma multiforme: a meta-analysis and systematic review |
title_full_unstemmed |
The impact of extended adjuvant temozolomide in newly diagnosed glioblastoma multiforme: a meta-analysis and systematic review |
title_sort |
impact of extended adjuvant temozolomide in newly diagnosed glioblastoma multiforme: a meta-analysis and systematic review |
publisher |
PAGEPress Publications |
series |
Oncology Reviews |
issn |
1970-5557 1970-5565 |
publishDate |
2020-02-01 |
description |
Surgical resection followed by concurrent radiation therapy and temozolomide (TMZ) chemotherapy is the current standard treatment for glioblastoma multiforme (GBM). The present metaanalysis investigated the impact of prolonged TMZ maintenance therapy (more than 6 cycles) in comparison with standard TMZ maintenance therapy (exactly six cycles) on overall survival (OS) and progression-free survival (PFS) of patients with GBM. A meta-analysis of the literature was conducted using Medline, PubMed, EMBASE and the Cochrane Library in accordance with PRISMA guidelines. Seven articles involving 1018 patients were included. The overall survival was higher in the case group (>6 cycles TMZ) compared to the control group (6 cycles TMZ) (Z=2.375, P=0.018). The lower and upper limits were between 1.002-10.467 months. The case group had higher progression-free survival compared with the control group (Z=3.84; P<0.001). The lower and upper limits were between 2.559-7.894 months. Evidence from this meta-analysis suggests that prolonged TMZ therapy compared to the standard 6-cycle TMZ therapy was associated with higher survival in patients with glioblastoma.
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topic |
Glioblastoma multiforme meta-analysis overall survival progression free survival temozolomide. |
url |
https://oncologyreviews.org/index.php/or/article/view/461 |
work_keys_str_mv |
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