Iodine-Mediated Facile One-Pot Access to N-Aryl-2-benzoxazolamines

Iodine-Mediated Facile One-Pot Access to N-Aryl-2-benzoxazolamines

Facile, iodine-mediated access to N-aryl-2-benzoxazolamines has been achieved in a one-pot manner under mild reaction conditions. Reaction of 2-aminophenols and aryl isothiocyanates afforded N-aryl-2-benzoxazolamines in the presence of molecular iodine and pyridine in tetrahydrofuran at room tempera...

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Bibliographic Details
Main Authors: Haruna Nariki, Takuya Miyamura, Daiki Matsui, Motohiro Sonoda, Shinji Tanimori
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2020-10-01
Series:SynOpen
Subjects:
iodine
benzoxazolamine
one-pot synthesis
cyclode­sulfurization
transition-metal-free
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1705982
Description
Summary:Facile, iodine-mediated access to N-aryl-2-benzoxazolamines has been achieved in a one-pot manner under mild reaction conditions. Reaction of 2-aminophenols and aryl isothiocyanates afforded N-aryl-2-benzoxazolamines in the presence of molecular iodine and pyridine in tetrahydrofuran at room temperature in moderate to excellent yields.
ISSN:2509-9396

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