Systems Biology Approach to Model the Life Cycle of Trypanosoma cruzi.
Due to recent advances in reprogramming cell phenotypes, many efforts have been dedicated to developing reverse engineering procedures for the identification of gene regulatory networks that emulate dynamical properties associated with the cell fates of a given biological system. In this work, we pr...
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doaj-961dfe7acf694ceb95bee909894716be2020-11-25T02:52:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01111e014694710.1371/journal.pone.0146947Systems Biology Approach to Model the Life Cycle of Trypanosoma cruzi.Alejandra CarreaLuis DiambraDue to recent advances in reprogramming cell phenotypes, many efforts have been dedicated to developing reverse engineering procedures for the identification of gene regulatory networks that emulate dynamical properties associated with the cell fates of a given biological system. In this work, we propose a systems biology approach for the reconstruction of the gene regulatory network underlying the dynamics of the Trypanosoma cruzi's life cycle. By means of an optimisation procedure, we embedded the steady state maintenance, and the known phenotypic transitions between these steady states in response to environmental cues, into the dynamics of a gene network model. In the resulting network architecture we identified a small subnetwork, formed by seven interconnected nodes, that controls the parasite's life cycle. The present approach could be useful for better understanding other single cell organisms with multiple developmental stages.http://europepmc.org/articles/PMC4709001?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alejandra Carrea Luis Diambra |
spellingShingle |
Alejandra Carrea Luis Diambra Systems Biology Approach to Model the Life Cycle of Trypanosoma cruzi. PLoS ONE |
author_facet |
Alejandra Carrea Luis Diambra |
author_sort |
Alejandra Carrea |
title |
Systems Biology Approach to Model the Life Cycle of Trypanosoma cruzi. |
title_short |
Systems Biology Approach to Model the Life Cycle of Trypanosoma cruzi. |
title_full |
Systems Biology Approach to Model the Life Cycle of Trypanosoma cruzi. |
title_fullStr |
Systems Biology Approach to Model the Life Cycle of Trypanosoma cruzi. |
title_full_unstemmed |
Systems Biology Approach to Model the Life Cycle of Trypanosoma cruzi. |
title_sort |
systems biology approach to model the life cycle of trypanosoma cruzi. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2016-01-01 |
description |
Due to recent advances in reprogramming cell phenotypes, many efforts have been dedicated to developing reverse engineering procedures for the identification of gene regulatory networks that emulate dynamical properties associated with the cell fates of a given biological system. In this work, we propose a systems biology approach for the reconstruction of the gene regulatory network underlying the dynamics of the Trypanosoma cruzi's life cycle. By means of an optimisation procedure, we embedded the steady state maintenance, and the known phenotypic transitions between these steady states in response to environmental cues, into the dynamics of a gene network model. In the resulting network architecture we identified a small subnetwork, formed by seven interconnected nodes, that controls the parasite's life cycle. The present approach could be useful for better understanding other single cell organisms with multiple developmental stages. |
url |
http://europepmc.org/articles/PMC4709001?pdf=render |
work_keys_str_mv |
AT alejandracarrea systemsbiologyapproachtomodelthelifecycleoftrypanosomacruzi AT luisdiambra systemsbiologyapproachtomodelthelifecycleoftrypanosomacruzi |
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