DNA topoisomerases as molecular targets for anticancer drugs
The significant role of topoisomerases in the control of DNA chain topology has been confirmed in numerous research conducted worldwide. The prevalence of these enzymes, as well as the key importance of topoisomerase in the proper functioning of cells, have made them the target of many scientific st...
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Online Access: | http://dx.doi.org/10.1080/14756366.2020.1821676 |
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doaj-96206ff0080a4bdea0c7c1d7b70bfb1d2021-07-15T13:10:33ZengTaylor & Francis GroupJournal of Enzyme Inhibition and Medicinal Chemistry1475-63661475-63742020-01-013511781179910.1080/14756366.2020.18216761821676DNA topoisomerases as molecular targets for anticancer drugsKamila Buzun0Anna Bielawska1Krzysztof Bielawski2Agnieszka Gornowicz3Department of Biotechnology, Medical University of BialystokDepartment of Biotechnology, Medical University of BialystokDepartment of Synthesis and Technology of Drugs, Medical University of BialystokDepartment of Biotechnology, Medical University of BialystokThe significant role of topoisomerases in the control of DNA chain topology has been confirmed in numerous research conducted worldwide. The prevalence of these enzymes, as well as the key importance of topoisomerase in the proper functioning of cells, have made them the target of many scientific studies conducted all over the world. This article is a comprehensive review of knowledge about topoisomerases and their inhibitors collected over the years. Studies on the structure–activity relationship and molecular docking are one of the key elements driving drug development. In addition to information on molecular targets, this article contains details on the structure–activity relationship of described classes of compounds. Moreover, the work also includes details about the structure of the compounds that drive the mode of action of topoisomerase inhibitors. Finally, selected topoisomerases inhibitors at the stage of clinical trials and their potential application in the chemotherapy of various cancers are described.http://dx.doi.org/10.1080/14756366.2020.1821676dna topoisomerasestopoisomerase inhibitorscanceranticancer activityanticancer drugs |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kamila Buzun Anna Bielawska Krzysztof Bielawski Agnieszka Gornowicz |
spellingShingle |
Kamila Buzun Anna Bielawska Krzysztof Bielawski Agnieszka Gornowicz DNA topoisomerases as molecular targets for anticancer drugs Journal of Enzyme Inhibition and Medicinal Chemistry dna topoisomerases topoisomerase inhibitors cancer anticancer activity anticancer drugs |
author_facet |
Kamila Buzun Anna Bielawska Krzysztof Bielawski Agnieszka Gornowicz |
author_sort |
Kamila Buzun |
title |
DNA topoisomerases as molecular targets for anticancer drugs |
title_short |
DNA topoisomerases as molecular targets for anticancer drugs |
title_full |
DNA topoisomerases as molecular targets for anticancer drugs |
title_fullStr |
DNA topoisomerases as molecular targets for anticancer drugs |
title_full_unstemmed |
DNA topoisomerases as molecular targets for anticancer drugs |
title_sort |
dna topoisomerases as molecular targets for anticancer drugs |
publisher |
Taylor & Francis Group |
series |
Journal of Enzyme Inhibition and Medicinal Chemistry |
issn |
1475-6366 1475-6374 |
publishDate |
2020-01-01 |
description |
The significant role of topoisomerases in the control of DNA chain topology has been confirmed in numerous research conducted worldwide. The prevalence of these enzymes, as well as the key importance of topoisomerase in the proper functioning of cells, have made them the target of many scientific studies conducted all over the world. This article is a comprehensive review of knowledge about topoisomerases and their inhibitors collected over the years. Studies on the structure–activity relationship and molecular docking are one of the key elements driving drug development. In addition to information on molecular targets, this article contains details on the structure–activity relationship of described classes of compounds. Moreover, the work also includes details about the structure of the compounds that drive the mode of action of topoisomerase inhibitors. Finally, selected topoisomerases inhibitors at the stage of clinical trials and their potential application in the chemotherapy of various cancers are described. |
topic |
dna topoisomerases topoisomerase inhibitors cancer anticancer activity anticancer drugs |
url |
http://dx.doi.org/10.1080/14756366.2020.1821676 |
work_keys_str_mv |
AT kamilabuzun dnatopoisomerasesasmoleculartargetsforanticancerdrugs AT annabielawska dnatopoisomerasesasmoleculartargetsforanticancerdrugs AT krzysztofbielawski dnatopoisomerasesasmoleculartargetsforanticancerdrugs AT agnieszkagornowicz dnatopoisomerasesasmoleculartargetsforanticancerdrugs |
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1721300949994045440 |