Association between the rs7903146 Polymorphism in the TCF7L2 Gene and Parameters Derived with Continuous Glucose Monitoring in Individuals without Diabetes.

The rs7903146-T allele in the transcription factor 7-like 2 (TCF7L2) gene has been associated with impaired pancreatic insulin secretion, enhanced liver glucose production, and an increased risk of type 2 diabetes. Nevertheless, the impact of rs7903146 on daily glucose trajectories remains unclear....

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Main Authors: Sabrina van der Kroef, Raymond Noordam, Joris Deelen, Abimbola A Akintola, Steffy W M Jansen, Iris Postmus, Carolien A Wijsman, Marian Beekman, Simon P Mooijaart, P Eline Slagboom, Diana van Heemst
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4767367?pdf=render