Triple stimulation (TriStim) before bilateral oophorectomy in a young woman with ovarian cancer: a case report and review of the literature
Abstract Background Double ovarian stimulation (DuoStim) involves two rounds of controlled ovarian stimulation (COS) and oocyte retrieval in immediate succession. It represents a promising approach to increase oocyte yield for patients with diminished ovarian reserve or those with limited time befor...
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doaj-9644888901514554a4a33dc0fcadff742020-11-25T03:57:09ZengBMCFertility Research and Practice2054-70992020-10-01611410.1186/s40738-020-00087-yTriple stimulation (TriStim) before bilateral oophorectomy in a young woman with ovarian cancer: a case report and review of the literatureLaura C. Gemmell0Jason D. Wright1Paula C. Brady2Department of Obstetrics and Gynecology, Columbia University Irving Medical Center/New York Presbyterian HospitalDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Columbia University Irving Medical CenterDepartment of Obstetrics and Gynecology, Columbia University Fertility Center, Columbia University Irving Medical CenterAbstract Background Double ovarian stimulation (DuoStim) involves two rounds of controlled ovarian stimulation (COS) and oocyte retrieval in immediate succession. It represents a promising approach to increase oocyte yield for patients with diminished ovarian reserve or those with limited time before fertility-threatening oncologic treatment. We report the case of a 31-year-old woman with Stage IC endometrioid ovarian cancer who underwent a triple stimulation or “TriStim,” completing three rounds of COS and oocyte retrieval within 42 days prior to bilateral salpingo-oophorectomy. Case presentation A 31 year old nulligravid woman presented for fertility preservation counseling following a bilateral ovarian cystectomy that revealed Stage IC endometroid adenocarcinoma arising within endometrioid borderline tumors. The patient was counseled for bilateral salpingo-oophorectomy, lymph node dissection, and omentectomy followed by three cycles of carboplatin/paclitaxel. Prior to this, all within six weeks, the patient underwent three rounds of controlled ovarian stimulation using an antagonist protocol and human chorionic gonadotropin (hCG) trigger, resulting in vitrification of nine two-pronuclear zygotes (2PN), after which definitive surgery was performed. Conclusions Advantages of DuoStim procedures are increasingly recognized, especially for oncology patients with limited time before potentially sterilizing cancer treatment. To our knowledge, this is the first report of a triple stimulation (“TriStim”). Our case highlights that triple stimulation is a viable option for patients needing urgent fertility preservation in order to maximize egg and embryo yield within a limited time period.http://link.springer.com/article/10.1186/s40738-020-00087-yDouble ovarian stimulationDuoStimFertility preservationOncofertilityTriple stimulationTriStim |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Laura C. Gemmell Jason D. Wright Paula C. Brady |
spellingShingle |
Laura C. Gemmell Jason D. Wright Paula C. Brady Triple stimulation (TriStim) before bilateral oophorectomy in a young woman with ovarian cancer: a case report and review of the literature Fertility Research and Practice Double ovarian stimulation DuoStim Fertility preservation Oncofertility Triple stimulation TriStim |
author_facet |
Laura C. Gemmell Jason D. Wright Paula C. Brady |
author_sort |
Laura C. Gemmell |
title |
Triple stimulation (TriStim) before bilateral oophorectomy in a young woman with ovarian cancer: a case report and review of the literature |
title_short |
Triple stimulation (TriStim) before bilateral oophorectomy in a young woman with ovarian cancer: a case report and review of the literature |
title_full |
Triple stimulation (TriStim) before bilateral oophorectomy in a young woman with ovarian cancer: a case report and review of the literature |
title_fullStr |
Triple stimulation (TriStim) before bilateral oophorectomy in a young woman with ovarian cancer: a case report and review of the literature |
title_full_unstemmed |
Triple stimulation (TriStim) before bilateral oophorectomy in a young woman with ovarian cancer: a case report and review of the literature |
title_sort |
triple stimulation (tristim) before bilateral oophorectomy in a young woman with ovarian cancer: a case report and review of the literature |
publisher |
BMC |
series |
Fertility Research and Practice |
issn |
2054-7099 |
publishDate |
2020-10-01 |
description |
Abstract Background Double ovarian stimulation (DuoStim) involves two rounds of controlled ovarian stimulation (COS) and oocyte retrieval in immediate succession. It represents a promising approach to increase oocyte yield for patients with diminished ovarian reserve or those with limited time before fertility-threatening oncologic treatment. We report the case of a 31-year-old woman with Stage IC endometrioid ovarian cancer who underwent a triple stimulation or “TriStim,” completing three rounds of COS and oocyte retrieval within 42 days prior to bilateral salpingo-oophorectomy. Case presentation A 31 year old nulligravid woman presented for fertility preservation counseling following a bilateral ovarian cystectomy that revealed Stage IC endometroid adenocarcinoma arising within endometrioid borderline tumors. The patient was counseled for bilateral salpingo-oophorectomy, lymph node dissection, and omentectomy followed by three cycles of carboplatin/paclitaxel. Prior to this, all within six weeks, the patient underwent three rounds of controlled ovarian stimulation using an antagonist protocol and human chorionic gonadotropin (hCG) trigger, resulting in vitrification of nine two-pronuclear zygotes (2PN), after which definitive surgery was performed. Conclusions Advantages of DuoStim procedures are increasingly recognized, especially for oncology patients with limited time before potentially sterilizing cancer treatment. To our knowledge, this is the first report of a triple stimulation (“TriStim”). Our case highlights that triple stimulation is a viable option for patients needing urgent fertility preservation in order to maximize egg and embryo yield within a limited time period. |
topic |
Double ovarian stimulation DuoStim Fertility preservation Oncofertility Triple stimulation TriStim |
url |
http://link.springer.com/article/10.1186/s40738-020-00087-y |
work_keys_str_mv |
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