Chitinase-3-Like Protein 1 (YKL-40) Reflects the Severity of Symptoms in Atopic Dermatitis
Chitinase-3-like protein 1 (YKL-40) is suggested to be associated with type 2 T helper response and atopy. The aim of the study was the evaluation of serum YKL-40 level in atopic dermatitis. The study was performed on 59 patients: 27 males and 32 females, aged from 18 to 64 years. The severity of th...
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doaj-9646de90153d41da8abd0a05a7facda52020-11-24T22:51:32ZengHindawi LimitedJournal of Immunology Research2314-88612314-71562017-01-01201710.1155/2017/57460315746031Chitinase-3-Like Protein 1 (YKL-40) Reflects the Severity of Symptoms in Atopic DermatitisJoanna Salomon0Łukasz Matusiak1Danuta Nowicka-Suszko2Jacek C Szepietowski3Department of Dermatology, Venereology and Allergology, Wrocław Medical University, Wrocław, PolandDepartment of Dermatology, Venereology and Allergology, Wrocław Medical University, Wrocław, PolandDepartment of Dermatology, Venereology and Allergology, Wrocław Medical University, Wrocław, PolandDepartment of Dermatology, Venereology and Allergology, Wrocław Medical University, Wrocław, PolandChitinase-3-like protein 1 (YKL-40) is suggested to be associated with type 2 T helper response and atopy. The aim of the study was the evaluation of serum YKL-40 level in atopic dermatitis. The study was performed on 59 patients: 27 males and 32 females, aged from 18 to 64 years. The severity of the disease was assessed by the SCORAD and objective SCORAD indexes. The severity of pruritus was measured by the visual analogue scale. Blood samples were taken to examine serum level of YKL-40, total IgE level, C-reactive protein level, white blood cell count, and neutrophil count. YKL-40 serum levels were significantly higher in patients with atopic dermatitis compared to the controls. There was a positive correlation between YKL-40 concentration and SCORAD, objective SCORAD, and pruritus. This study has shown that YKL-40 serum level is increased in patients with atopic dermatitis and reflects the severity of symptoms.http://dx.doi.org/10.1155/2017/5746031 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Joanna Salomon Łukasz Matusiak Danuta Nowicka-Suszko Jacek C Szepietowski |
spellingShingle |
Joanna Salomon Łukasz Matusiak Danuta Nowicka-Suszko Jacek C Szepietowski Chitinase-3-Like Protein 1 (YKL-40) Reflects the Severity of Symptoms in Atopic Dermatitis Journal of Immunology Research |
author_facet |
Joanna Salomon Łukasz Matusiak Danuta Nowicka-Suszko Jacek C Szepietowski |
author_sort |
Joanna Salomon |
title |
Chitinase-3-Like Protein 1 (YKL-40) Reflects the Severity of Symptoms in Atopic Dermatitis |
title_short |
Chitinase-3-Like Protein 1 (YKL-40) Reflects the Severity of Symptoms in Atopic Dermatitis |
title_full |
Chitinase-3-Like Protein 1 (YKL-40) Reflects the Severity of Symptoms in Atopic Dermatitis |
title_fullStr |
Chitinase-3-Like Protein 1 (YKL-40) Reflects the Severity of Symptoms in Atopic Dermatitis |
title_full_unstemmed |
Chitinase-3-Like Protein 1 (YKL-40) Reflects the Severity of Symptoms in Atopic Dermatitis |
title_sort |
chitinase-3-like protein 1 (ykl-40) reflects the severity of symptoms in atopic dermatitis |
publisher |
Hindawi Limited |
series |
Journal of Immunology Research |
issn |
2314-8861 2314-7156 |
publishDate |
2017-01-01 |
description |
Chitinase-3-like protein 1 (YKL-40) is suggested to be associated with type 2 T helper response and atopy. The aim of the study was the evaluation of serum YKL-40 level in atopic dermatitis. The study was performed on 59 patients: 27 males and 32 females, aged from 18 to 64 years. The severity of the disease was assessed by the SCORAD and objective SCORAD indexes. The severity of pruritus was measured by the visual analogue scale. Blood samples were taken to examine serum level of YKL-40, total IgE level, C-reactive protein level, white blood cell count, and neutrophil count. YKL-40 serum levels were significantly higher in patients with atopic dermatitis compared to the controls. There was a positive correlation between YKL-40 concentration and SCORAD, objective SCORAD, and pruritus. This study has shown that YKL-40 serum level is increased in patients with atopic dermatitis and reflects the severity of symptoms. |
url |
http://dx.doi.org/10.1155/2017/5746031 |
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