A novel association of BoLA DRB3 alleles in BLV infected cattle with different proviral loads
Bovine leukemia virus (BLV) is associated with the most common neoplastic disease of cattle. BLV has a silent dissemination in the herd due to infected cell exchange, thus the concentration of BLV-infected cells in blood should play a major role in the success of viral transmission. Genes from Bovi...
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2017-11-01
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doaj-964a7dd564c04f959e82dcae8a85b5932020-11-25T03:50:15ZengUniversidade de São PauloBrazilian Journal of Veterinary Research and Animal Science1413-95961678-44562017-11-0154310.11606/issn.1678-4456.bjvras.2017.123769A novel association of BoLA DRB3 alleles in BLV infected cattle with different proviral loadsMaría Victoria Nieto Farias0María Eugenia Caffaro1Pamela Anahí Lendez2Juan Passucci3Mario Poli4María Carolina Ceriani5Guillermina Laura Dolcini6Universidad Nacional del Centro de la Provincia de Buenos Aires, Facultad de Ciencias Veterinarias, Centro de Investigación Veterinaria de Tandil, Laboratorio de VirologíaInstituto Nacional de Tecnología Agropecuaria, Centro de Investigación en Ciencias Veterinarias y Agronómicas, Instituto de Genética “Edwald A. Favret”Universidad Nacional del Centro de la Provincia de Buenos Aires, Facultad de Ciencias Veterinarias, Centro de Investigación Veterinaria de Tandil, Laboratorio de VirologíaUniversidad Nacional del Centro de la Provincia de Buenos Aires, Facultad de Ciencias Veterinarias, Área de EpidemiologíaInstituto Nacional de Tecnología Agropecuaria, Centro de Investigación en Ciencias Veterinarias y Agronómicas, Instituto de Genética “Edwald A. Favret”Universidad Nacional del Centro de la Provincia de Buenos Aires, Facultad de Ciencias Veterinarias, Centro de Investigación Veterinaria de Tandil, Laboratorio de VirologíaUniversidad Nacional del Centro de la Provincia de Buenos Aires, Facultad de Ciencias Veterinarias, Centro de Investigación Veterinaria de Tandil, Laboratorio de Virología Bovine leukemia virus (BLV) is associated with the most common neoplastic disease of cattle. BLV has a silent dissemination in the herd due to infected cell exchange, thus the concentration of BLV-infected cells in blood should play a major role in the success of viral transmission. Genes from Bovine leukocyte antigen (BoLA), the MHC system of cattle, are associated with genetic resistance and susceptibility to a wide range of diseases, and also with production traits. Some BoLA DRB3.2 allele polymorphisms in Holstein cattle have been associated with resistance or susceptibility to BLV-disease development, or with proviral load (PVL). This investigation studied 107 BLV-infected Argentinean Holstein dairy cows, all of them belonging to one herd. PVL was analysed by qPCR and animals were classified as high proviral load (HPVL, N = 88) and low proviral load (LPVL, N = 19), and BoLA DRB3.2 alleles were genotyped. Alleles BoLA DRB3.2*1501 and *1201 were significantly associated with HPVL (p = 0.0230 and p = 0.0111 respectively), while allele BoLA DRB3.2*0201 was significantly associated with LPVL (p = 0.0030). The present study aims at contributing to the knowledge of the association between BoLA polymorphism and development of a BLV infection profile. Genes that best explain the PVL in this population resulted BoLA DRB3.2*0201 (as a protection factor) and *1501 (as a risk factor). Allelic differences may play an important role in the development of effective immune responses. A better understanding of how BoLA polymorphism contributes to these responses and the establishment of a BLV status is desirable to schedule and evaluate control measures. http://www.revistas.usp.br/bjvras/article/view/123769BLVProviral loadBoLA DRB3 polymorphism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
María Victoria Nieto Farias María Eugenia Caffaro Pamela Anahí Lendez Juan Passucci Mario Poli María Carolina Ceriani Guillermina Laura Dolcini |
spellingShingle |
María Victoria Nieto Farias María Eugenia Caffaro Pamela Anahí Lendez Juan Passucci Mario Poli María Carolina Ceriani Guillermina Laura Dolcini A novel association of BoLA DRB3 alleles in BLV infected cattle with different proviral loads Brazilian Journal of Veterinary Research and Animal Science BLV Proviral load BoLA DRB3 polymorphism |
author_facet |
María Victoria Nieto Farias María Eugenia Caffaro Pamela Anahí Lendez Juan Passucci Mario Poli María Carolina Ceriani Guillermina Laura Dolcini |
author_sort |
María Victoria Nieto Farias |
title |
A novel association of BoLA DRB3 alleles in BLV infected cattle with different proviral loads |
title_short |
A novel association of BoLA DRB3 alleles in BLV infected cattle with different proviral loads |
title_full |
A novel association of BoLA DRB3 alleles in BLV infected cattle with different proviral loads |
title_fullStr |
A novel association of BoLA DRB3 alleles in BLV infected cattle with different proviral loads |
title_full_unstemmed |
A novel association of BoLA DRB3 alleles in BLV infected cattle with different proviral loads |
title_sort |
novel association of bola drb3 alleles in blv infected cattle with different proviral loads |
publisher |
Universidade de São Paulo |
series |
Brazilian Journal of Veterinary Research and Animal Science |
issn |
1413-9596 1678-4456 |
publishDate |
2017-11-01 |
description |
Bovine leukemia virus (BLV) is associated with the most common neoplastic disease of cattle. BLV has a silent dissemination in the herd due to infected cell exchange, thus the concentration of BLV-infected cells in blood should play a major role in the success of viral transmission. Genes from Bovine leukocyte antigen (BoLA), the MHC system of cattle, are associated with genetic resistance and susceptibility to a wide range of diseases, and also with production traits. Some BoLA DRB3.2 allele polymorphisms in Holstein cattle have been associated with resistance or susceptibility to BLV-disease development, or with proviral load (PVL). This investigation studied 107 BLV-infected Argentinean Holstein dairy cows, all of them belonging to one herd. PVL was analysed by qPCR and animals were classified as high proviral load (HPVL, N = 88) and low proviral load (LPVL, N = 19), and BoLA DRB3.2 alleles were genotyped. Alleles BoLA DRB3.2*1501 and *1201 were significantly associated with HPVL (p = 0.0230 and p = 0.0111 respectively), while allele BoLA DRB3.2*0201 was significantly associated with LPVL (p = 0.0030). The present study aims at contributing to the knowledge of the association between BoLA polymorphism and development of a BLV infection profile. Genes that best explain the PVL in this population resulted BoLA DRB3.2*0201 (as a protection factor) and *1501 (as a risk factor). Allelic differences may play an important role in the development of effective immune responses. A better understanding of how BoLA polymorphism contributes to these responses and the establishment of a BLV status is desirable to schedule and evaluate control measures.
|
topic |
BLV Proviral load BoLA DRB3 polymorphism |
url |
http://www.revistas.usp.br/bjvras/article/view/123769 |
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