Preparation and Evaluation of Novel Folate Isonitrile <sup>99m</sup>Tc Complexes as Potential Tumor Imaging Agents to Target Folate Receptors

Preparation and Evaluation of Novel Folate Isonitrile <sup>99m</sup>Tc Complexes as Potential Tumor Imaging Agents to Target Folate Receptors

In order to seek novel technetium-99m folate receptor-targeting agents, two folate derivatives (CN5FA and CNPFA) were synthesized and radiolabeled to obtain [<sup>99m</sup>Tc]Tc-CN5FA and [<sup>99m</sup>Tc]Tc-CNPFA complexes, which exhibited high radiochemical purity (>95%...

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Bibliographic Details
Main Authors: Junhong Feng, Xuran Zhang, Qing Ruan, Yuhao Jiang, Junbo Zhang
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Molecules
Subjects:
<sup>99m</sup>Tc
isonitrile
folate receptor
SPECT/CT imaging
Online Access:https://www.mdpi.com/1420-3049/26/15/4552

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