Crosslinked hydrogels—a promising class of insoluble solid molecular dispersion carriers for enhancing the delivery of poorly soluble drugs
Water-insoluble materials containing amorphous solid dispersions (ASD) are an emerging category of drug carriers which can effectively improve dissolution kinetics and kinetic solubility of poorly soluble drugs. ASDs based on water-insoluble crosslinked hydrogels have unique features in contrast to...
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2014-02-01
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doaj-96589e4ddee44d1bbd935806386521e22020-11-24T23:32:24ZengElsevierActa Pharmaceutica Sinica B2211-38352211-38432014-02-0141263610.1016/j.apsb.2013.12.002Crosslinked hydrogels—a promising class of insoluble solid molecular dispersion carriers for enhancing the delivery of poorly soluble drugsDajun D. SunPing I. LeeWater-insoluble materials containing amorphous solid dispersions (ASD) are an emerging category of drug carriers which can effectively improve dissolution kinetics and kinetic solubility of poorly soluble drugs. ASDs based on water-insoluble crosslinked hydrogels have unique features in contrast to those based on conventional water-soluble and water-insoluble carriers. For example, solid molecular dispersions of poorly soluble drugs in poly(2-hydroxyethyl methacrylate) (PHEMA) can maintain a high level of supersaturation over a prolonged period of time via a feedback-controlled diffusion mechanism thus avoiding the initial surge of supersaturation followed by a sharp decline in drug concentration typically encountered with ASDs based on water-soluble polymers. The creation of both immediate- and controlled-release ASD dosage forms is also achievable with the PHEMA based hydrogels. So far, ASD systems based on glassy PHEMA have been shown to be very effective in retarding precipitation of amorphous drugs in the solid state to achieve a robust physical stability. This review summarizes recent research efforts in investigating the potential of developing crosslinked PHEMA hydrogels as a promising alternative to conventional water-soluble ASD carriers, and a related finding that the rate of supersaturation generation does affect the kinetic solubility profiles implications to hydrogel based ASDs.http://www.sciencedirect.com/science/article/pii/S221138351300107XAmorphous solid dispersionsCrosslinked hydrogelsPoly(2-hydroxyethylmethacrylate)SupersaturationKinetic solubility |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dajun D. Sun Ping I. Lee |
spellingShingle |
Dajun D. Sun Ping I. Lee Crosslinked hydrogels—a promising class of insoluble solid molecular dispersion carriers for enhancing the delivery of poorly soluble drugs Acta Pharmaceutica Sinica B Amorphous solid dispersions Crosslinked hydrogels Poly(2-hydroxyethylmethacrylate) Supersaturation Kinetic solubility |
author_facet |
Dajun D. Sun Ping I. Lee |
author_sort |
Dajun D. Sun |
title |
Crosslinked hydrogels—a promising class of insoluble solid molecular dispersion carriers for enhancing the delivery of poorly soluble drugs |
title_short |
Crosslinked hydrogels—a promising class of insoluble solid molecular dispersion carriers for enhancing the delivery of poorly soluble drugs |
title_full |
Crosslinked hydrogels—a promising class of insoluble solid molecular dispersion carriers for enhancing the delivery of poorly soluble drugs |
title_fullStr |
Crosslinked hydrogels—a promising class of insoluble solid molecular dispersion carriers for enhancing the delivery of poorly soluble drugs |
title_full_unstemmed |
Crosslinked hydrogels—a promising class of insoluble solid molecular dispersion carriers for enhancing the delivery of poorly soluble drugs |
title_sort |
crosslinked hydrogels—a promising class of insoluble solid molecular dispersion carriers for enhancing the delivery of poorly soluble drugs |
publisher |
Elsevier |
series |
Acta Pharmaceutica Sinica B |
issn |
2211-3835 2211-3843 |
publishDate |
2014-02-01 |
description |
Water-insoluble materials containing amorphous solid dispersions (ASD) are an emerging category of drug carriers which can effectively improve dissolution kinetics and kinetic solubility of poorly soluble drugs. ASDs based on water-insoluble crosslinked hydrogels have unique features in contrast to those based on conventional water-soluble and water-insoluble carriers. For example, solid molecular dispersions of poorly soluble drugs in poly(2-hydroxyethyl methacrylate) (PHEMA) can maintain a high level of supersaturation over a prolonged period of time via a feedback-controlled diffusion mechanism thus avoiding the initial surge of supersaturation followed by a sharp decline in drug concentration typically encountered with ASDs based on water-soluble polymers. The creation of both immediate- and controlled-release ASD dosage forms is also achievable with the PHEMA based hydrogels. So far, ASD systems based on glassy PHEMA have been shown to be very effective in retarding precipitation of amorphous drugs in the solid state to achieve a robust physical stability. This review summarizes recent research efforts in investigating the potential of developing crosslinked PHEMA hydrogels as a promising alternative to conventional water-soluble ASD carriers, and a related finding that the rate of supersaturation generation does affect the kinetic solubility profiles implications to hydrogel based ASDs. |
topic |
Amorphous solid dispersions Crosslinked hydrogels Poly(2-hydroxyethylmethacrylate) Supersaturation Kinetic solubility |
url |
http://www.sciencedirect.com/science/article/pii/S221138351300107X |
work_keys_str_mv |
AT dajundsun crosslinkedhydrogelsapromisingclassofinsolublesolidmoleculardispersioncarriersforenhancingthedeliveryofpoorlysolubledrugs AT pingilee crosslinkedhydrogelsapromisingclassofinsolublesolidmoleculardispersioncarriersforenhancingthedeliveryofpoorlysolubledrugs |
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1725534356044251136 |