Microvascular pericytes in brain-associated vascular disease
Pericytes, as mural cells of microvessels, are important regulators of vascular structure formation and function maintenance in the process of cerebrovascular maturation, cerebrovascular homeostasis and disease. In the recent years, they have gradually become the hot spot of the research. In fact, p...
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doaj-965cf9435c85413cabf1784abccdac412021-05-20T07:39:34ZengElsevierBiomedicine & Pharmacotherapy0753-33222020-01-01121109633Microvascular pericytes in brain-associated vascular diseaseQi Liu0Yingxi Yang1Xiaonong Fan2First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 314 An Shan Xi Road, Nan Kai District, Tianjin 300193, ChinaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 314 An Shan Xi Road, Nan Kai District, Tianjin 300193, ChinaInstitute of acupuncture and moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 314 An Shan Xi Road, Nan Kai District, Tianjin 300193, China; Tianjin Key Laboratory of Acupuncture and Moxibustion Science, National Acupuncture Clinical Research Center, China; Corresponding author at: Institute of acupuncture and moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 314 An Shan Xi Road, Nan Kai District, Tianjin 300193, China.Pericytes, as mural cells of microvessels, are important regulators of vascular structure formation and function maintenance in the process of cerebrovascular maturation, cerebrovascular homeostasis and disease. In the recent years, they have gradually become the hot spot of the research. In fact, pericytes are not isolated cells. Their functions can’t be played without the cooperation with surrounding cells. In the neurovascular unit (NVU), they communicate with other cells by direct contact or through signaling pathways to regulate cerebral vascular function and the state of blood vessels in response to changes in neural activity. Pericytes are closely related to the cerebrovascular and central nervous system disease. Currently, a large number of clinical and animal studies have confirmed that pericytes biological function is related to cerebral blood flow, blood-brain barrier permeability, cerebral vascular formation maintenance, and neuroinflammation. The objective of this review is to highlight the role of pericytes in cerebral microvessels as well as their relationships with stroke, dementia, and brain tumor disease. The possible pathogenic mechanisms between pericytes and these diseases will also be described. As a matter of fact, the role of pericytes in the brain-associated vascular disease may provide new ideas for clinical treatment.http://www.sciencedirect.com/science/article/pii/S0753332219352552PericytesFunctionTherapyBrain-associated vascular disease |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qi Liu Yingxi Yang Xiaonong Fan |
spellingShingle |
Qi Liu Yingxi Yang Xiaonong Fan Microvascular pericytes in brain-associated vascular disease Biomedicine & Pharmacotherapy Pericytes Function Therapy Brain-associated vascular disease |
author_facet |
Qi Liu Yingxi Yang Xiaonong Fan |
author_sort |
Qi Liu |
title |
Microvascular pericytes in brain-associated vascular disease |
title_short |
Microvascular pericytes in brain-associated vascular disease |
title_full |
Microvascular pericytes in brain-associated vascular disease |
title_fullStr |
Microvascular pericytes in brain-associated vascular disease |
title_full_unstemmed |
Microvascular pericytes in brain-associated vascular disease |
title_sort |
microvascular pericytes in brain-associated vascular disease |
publisher |
Elsevier |
series |
Biomedicine & Pharmacotherapy |
issn |
0753-3322 |
publishDate |
2020-01-01 |
description |
Pericytes, as mural cells of microvessels, are important regulators of vascular structure formation and function maintenance in the process of cerebrovascular maturation, cerebrovascular homeostasis and disease. In the recent years, they have gradually become the hot spot of the research. In fact, pericytes are not isolated cells. Their functions can’t be played without the cooperation with surrounding cells. In the neurovascular unit (NVU), they communicate with other cells by direct contact or through signaling pathways to regulate cerebral vascular function and the state of blood vessels in response to changes in neural activity. Pericytes are closely related to the cerebrovascular and central nervous system disease. Currently, a large number of clinical and animal studies have confirmed that pericytes biological function is related to cerebral blood flow, blood-brain barrier permeability, cerebral vascular formation maintenance, and neuroinflammation. The objective of this review is to highlight the role of pericytes in cerebral microvessels as well as their relationships with stroke, dementia, and brain tumor disease. The possible pathogenic mechanisms between pericytes and these diseases will also be described. As a matter of fact, the role of pericytes in the brain-associated vascular disease may provide new ideas for clinical treatment. |
topic |
Pericytes Function Therapy Brain-associated vascular disease |
url |
http://www.sciencedirect.com/science/article/pii/S0753332219352552 |
work_keys_str_mv |
AT qiliu microvascularpericytesinbrainassociatedvasculardisease AT yingxiyang microvascularpericytesinbrainassociatedvasculardisease AT xiaonongfan microvascularpericytesinbrainassociatedvasculardisease |
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