Contrast-induced acute kidney injury in chronic coronary artery disease patients with diabetes mellitus and obesity

• Main Authors: O. Iu. Mironova, I. I. Staroverov, O. A. Sivakova, A. D. Deev, V. V. Fomin
• Format: Article
• Language: Russian
• Published: "Consilium Medicum" Publishing house 2020-11-01
• Series: Терапевтический архив
• Subjects: contrast-induced acute kidney injury; contrast-induced nephropathy; contrast-associated acute kidney injury; coronary artery disease; diabetes mellitus; obesity; percutaneous coronary intervention; contrast
• Online Access: https://ter-arkhiv.ru/0040-3660/article/viewFile/50972/34461
• ISSN: 0040-3660; 2309-5342

Aim.To assess the influence of diabetes mellitus and obesity on contrast-induced acute kidney injury risk in patients with chronic coronary artery disease requiring percutaneous coronary intervention. Materials and methods.1023 patients with chronic coronary artery disease were enrolled in a prospective, open, cohort study (ClinicalTrials.gov ID NCT04014153). Contrast-induced acute kidney injury was defined as an increase of 25% or more, or an absolute increase of 0.5 mg/dl or more in serum creatinine from baseline value, assessed at 48 hours following the administration of the contrast. The majority of the patients were overweight male ones with BMI 29.25.5 kg/m2. The primary endpoint of the study was the development of contrast-induced acute kidney injury according to KDIGO criteria. Results.The prevalence of contrast-induced acute kidney injury was 12.9% (132 patients). 21.2% suffered from diabetes mellitus, 43% were obese and 12.9% had both diabetes mellitus and obesity. Diabetes wasnt a statistically significant independent risk factor of the contrast-induced acute kidney injury, as well as the combination of diabetes and obesity. In the group of obese patients the prevalence of contrast-induced acute kidney injury was higher (13.4%vs12.5%), but didnt meet statistical significance (p=0.7, OR 0.924, 95% CI 0.641.325). According to the multiple logistic regression model, female gender, age, BMI, weight, arterial hypertension, baseline creatinine were the risk factors of the contrast-induced acute kidney injury development (AUC 0.742,p0.0001). Conclusion.Diabetes mellitus was not associated with higher incidence of contrast-induced acute kidney injury. The prevalence of contrast-induced kidney injury was higher in the group of patients with BMI30 kg/m2, but didnt meet statistical significance and needs further evaluation in larger studies.