Efectos del D-005, extracto lipídico del fruto de Acrocomia Crispa, sobre el estrés oxidativo inducido por tetracloruro de carbono en ratas
Oxidative stress is produced by the imbalance between the substances or factors pro-oxidant and the antioxidant defense mechanisms, which in turn plays an important role in the development and progression of various pathologies. D-005, lipid extract from the fruits of Acrocomia crispa contains a rep...
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doaj-9660c233ca564f729d3830c9f428ebcf2021-06-29T15:32:50ZengCentro Nacional de Investigaciones CientíficasRevista CENIC. Ciencias Biológicas0253-56882221-24502021-06-01522137145Efectos del D-005, extracto lipídico del fruto de Acrocomia Crispa, sobre el estrés oxidativo inducido por tetracloruro de carbono en ratasAmbar Oyarzábal Yera0https://orcid.org/0000-0003-3014-5457Yohani Pérez Guerra1https://orcid.org/0000-0002-3964-2698Sonia Jiménez Despaigne2https://orcid.org/0000-0002-8506-426XVivian Molina Cuevas3https://orcid.org/0000-0003-0706-5547Centro Nacional de Investigaciones Científicas Centro de Productos Naturales Dirección de Investigación Desarrollo e innovación Grupo de FarmacologíaCentro Nacional de Investigaciones Científicas. Dirección de CalidadCentro Nacional de Investigaciones Científicas Centro de Productos Naturales Dirección de Investigación Desarrollo e innovación Grupo de FarmacologíaCentro Nacional de Investigaciones Científicas Centro de Productos Naturales Dirección de Investigación Desarrollo e innovación Grupo de FarmacologíaOxidative stress is produced by the imbalance between the substances or factors pro-oxidant and the antioxidant defense mechanisms, which in turn plays an important role in the development and progression of various pathologies. D-005, lipid extract from the fruits of Acrocomia crispa contains a reproducible mixture of fatty acids, such as: oleic, palmitic, lauric, myristic, palmitoleic, caprylic, capric, and stearic that have antioxidant properties. The objective of this work is to evaluate the effect of D-005 administered as single oral doses on the increase in indicators of oxidative stress induced by carbon tetrachloride (CCl4) in rats. The animals were randomly distributed into seven groups: a negative control without damage and six groups to which CCl4 was administered (intraperitoneal): a positive control treated with vehicle, four with D-005 (5-100 mg/kg), and one with grape seed extract (ESU) (250 mg/kg). The animals in the positive control group (with CCl4) reached significantly higher values of malondialdehyde-marker of lipid peroxidation-, sulfhydryl groups-marker of protein oxidation- and serum transaminases-marker of liver damage- with respect to the animals of the negative control group (without damage). D-005 and ESU markedly and significantly prevented this increase. In conclusion, D-005 administered as single oral doses of 5, 25, 50, and 100 mg/kg inhibits lipid peroxidation and protein oxidation, as well as CCl4-induced liver damage.https://revista.cnic.cu/index.php/RevBiol/article/view/910/733d-005lipid peroxidationprotein oxidation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ambar Oyarzábal Yera Yohani Pérez Guerra Sonia Jiménez Despaigne Vivian Molina Cuevas |
spellingShingle |
Ambar Oyarzábal Yera Yohani Pérez Guerra Sonia Jiménez Despaigne Vivian Molina Cuevas Efectos del D-005, extracto lipídico del fruto de Acrocomia Crispa, sobre el estrés oxidativo inducido por tetracloruro de carbono en ratas Revista CENIC. Ciencias Biológicas d-005 lipid peroxidation protein oxidation |
author_facet |
Ambar Oyarzábal Yera Yohani Pérez Guerra Sonia Jiménez Despaigne Vivian Molina Cuevas |
author_sort |
Ambar Oyarzábal Yera |
title |
Efectos del D-005, extracto lipídico del fruto de Acrocomia Crispa, sobre el estrés oxidativo inducido por tetracloruro de carbono en ratas |
title_short |
Efectos del D-005, extracto lipídico del fruto de Acrocomia Crispa, sobre el estrés oxidativo inducido por tetracloruro de carbono en ratas |
title_full |
Efectos del D-005, extracto lipídico del fruto de Acrocomia Crispa, sobre el estrés oxidativo inducido por tetracloruro de carbono en ratas |
title_fullStr |
Efectos del D-005, extracto lipídico del fruto de Acrocomia Crispa, sobre el estrés oxidativo inducido por tetracloruro de carbono en ratas |
title_full_unstemmed |
Efectos del D-005, extracto lipídico del fruto de Acrocomia Crispa, sobre el estrés oxidativo inducido por tetracloruro de carbono en ratas |
title_sort |
efectos del d-005, extracto lipídico del fruto de acrocomia crispa, sobre el estrés oxidativo inducido por tetracloruro de carbono en ratas |
publisher |
Centro Nacional de Investigaciones Científicas |
series |
Revista CENIC. Ciencias Biológicas |
issn |
0253-5688 2221-2450 |
publishDate |
2021-06-01 |
description |
Oxidative stress is produced by the imbalance between the substances or factors pro-oxidant and the antioxidant defense mechanisms, which in turn plays an important role in the development and progression of various pathologies. D-005, lipid extract from the fruits of Acrocomia crispa contains a reproducible mixture of fatty acids, such as: oleic, palmitic, lauric, myristic, palmitoleic, caprylic, capric, and stearic that have antioxidant properties. The objective of this work is to evaluate the effect of D-005 administered as single oral doses on the increase in indicators of oxidative stress induced by carbon tetrachloride (CCl4) in rats. The animals were randomly distributed into seven groups: a negative control without damage and six groups to which CCl4 was administered (intraperitoneal): a positive control treated with vehicle, four with D-005 (5-100 mg/kg), and one with grape seed extract (ESU) (250 mg/kg). The animals in the positive control group (with CCl4) reached significantly higher values of malondialdehyde-marker of lipid peroxidation-, sulfhydryl groups-marker of protein oxidation- and serum transaminases-marker of liver damage- with respect to the animals of the negative control group (without damage). D-005 and ESU markedly and significantly prevented this increase. In conclusion, D-005 administered as single oral doses of 5, 25, 50, and 100 mg/kg inhibits lipid peroxidation and protein oxidation, as well as CCl4-induced liver damage. |
topic |
d-005 lipid peroxidation protein oxidation |
url |
https://revista.cnic.cu/index.php/RevBiol/article/view/910/733 |
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