Efectos del D-005, extracto lipídico del fruto de Acrocomia Crispa, sobre el estrés oxidativo inducido por tetracloruro de carbono en ratas

• Main Authors: Ambar Oyarzábal Yera, Yohani Pérez Guerra, Sonia Jiménez Despaigne, Vivian Molina Cuevas
• Format: Article
• Language: English
• Published: Centro Nacional de Investigaciones Científicas 2021-06-01
• Series: Revista CENIC. Ciencias Biológicas
• Subjects: d-005; lipid peroxidation; protein oxidation
• Online Access: https://revista.cnic.cu/index.php/RevBiol/article/view/910/733

Oxidative stress is produced by the imbalance between the substances or factors pro-oxidant and the antioxidant defense mechanisms, which in turn plays an important role in the development and progression of various pathologies. D-005, lipid extract from the fruits of Acrocomia crispa contains a reproducible mixture of fatty acids, such as: oleic, palmitic, lauric, myristic, palmitoleic, caprylic, capric, and stearic that have antioxidant properties. The objective of this work is to evaluate the effect of D-005 administered as single oral doses on the increase in indicators of oxidative stress induced by carbon tetrachloride (CCl4) in rats. The animals were randomly distributed into seven groups: a negative control without damage and six groups to which CCl4 was administered (intraperitoneal): a positive control treated with vehicle, four with D-005 (5-100 mg/kg), and one with grape seed extract (ESU) (250 mg/kg). The animals in the positive control group (with CCl4) reached significantly higher values of malondialdehyde-marker of lipid peroxidation-, sulfhydryl groups-marker of protein oxidation- and serum transaminases-marker of liver damage- with respect to the animals of the negative control group (without damage). D-005 and ESU markedly and significantly prevented this increase. In conclusion, D-005 administered as single oral doses of 5, 25, 50, and 100 mg/kg inhibits lipid peroxidation and protein oxidation, as well as CCl4-induced liver damage.