Triglyceride is independently correlated with insulin resistance and islet beta cell function: a study in population with different glucose and lipid metabolism states
Abstract Background Previous studies on the effects of lipotoxicity and oxidative stress on islet beta cell function mainly focused on patients with diabetes, whereas studies on normal glucose tolerance (NGT) are few. The aim of this study was to explore the relationships among triglyceride (TG), hi...
Main Authors: | , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2020-06-01
|
Series: | Lipids in Health and Disease |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12944-020-01303-w |
id |
doaj-9661656427594a31a9dff35283c70e93 |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Minglei Ma Haibin Liu Jie Yu Shuli He Pingping Li Chunxiao Ma Huabing Zhang Lingling Xu Fan Ping Wei Li Qi Sun Yuxiu Li |
spellingShingle |
Minglei Ma Haibin Liu Jie Yu Shuli He Pingping Li Chunxiao Ma Huabing Zhang Lingling Xu Fan Ping Wei Li Qi Sun Yuxiu Li Triglyceride is independently correlated with insulin resistance and islet beta cell function: a study in population with different glucose and lipid metabolism states Lipids in Health and Disease Glucose Lipid Diabetes Triglyceride Superoxide dismutase Insulin resistance |
author_facet |
Minglei Ma Haibin Liu Jie Yu Shuli He Pingping Li Chunxiao Ma Huabing Zhang Lingling Xu Fan Ping Wei Li Qi Sun Yuxiu Li |
author_sort |
Minglei Ma |
title |
Triglyceride is independently correlated with insulin resistance and islet beta cell function: a study in population with different glucose and lipid metabolism states |
title_short |
Triglyceride is independently correlated with insulin resistance and islet beta cell function: a study in population with different glucose and lipid metabolism states |
title_full |
Triglyceride is independently correlated with insulin resistance and islet beta cell function: a study in population with different glucose and lipid metabolism states |
title_fullStr |
Triglyceride is independently correlated with insulin resistance and islet beta cell function: a study in population with different glucose and lipid metabolism states |
title_full_unstemmed |
Triglyceride is independently correlated with insulin resistance and islet beta cell function: a study in population with different glucose and lipid metabolism states |
title_sort |
triglyceride is independently correlated with insulin resistance and islet beta cell function: a study in population with different glucose and lipid metabolism states |
publisher |
BMC |
series |
Lipids in Health and Disease |
issn |
1476-511X |
publishDate |
2020-06-01 |
description |
Abstract Background Previous studies on the effects of lipotoxicity and oxidative stress on islet beta cell function mainly focused on patients with diabetes, whereas studies on normal glucose tolerance (NGT) are few. The aim of this study was to explore the relationships among triglyceride (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), oxidative stress indicators, insulin resistance, and beta cell function in populations with different glucose and lipid metabolism states. Methods A total of 517 individuals were recruited from a rural community in Beijing, China. Glucose metabolism status was defined according to the results of a 75-g oral glucose tolerance test (OGTT). Dyslipidemia was defined as abnormal TG, HDL-c, or LDL-c levels. The population was divided into four groups: individuals with normal glucose and lipid levels (group A, n = 62); those with dyslipidemia alone (group B, n = 82); those with dysglycemia alone (group C, n = 121); and those with dysglycemia and dyslipidemia (group D, n = 247). Oxidative stress indicators, including superoxide dismutase (SOD), glutathione reductase (GR) and 8-hydroxydeoxyguanosine (8-OHdG), were measured. Homeostasis model assessment of insulin resistance (HOMA-IR) and glucose disposition index (DI30, DI120) were calculated to assess insulin resistance and islet beta cell function, respectively. Stratified multiple linear regression analysis was used to explore relationships between TG, HDL-c, LDL-c, oxidative stress indicators, and insulin resistance (natural log transformation of HOMA-IR, LnHOMA-IR) and beta cell function (natural log transformation of DI30, Ln DI30). Results Compared with the control group, populations with dyslipidemia and/or dysglycemia showed significantly increased insulin resistance. Dyslipidemia aggravated insulin resistance and beta cell dysfunction in individuals with dysglycemia. Stratified regression analysis showed that TG positively correlated with LnHOMA-IR in individuals with normal glucose levels (beta = 0.321, 0.327, P = 0.011, 0.003 in groups A and B, respectively) and negatively correlated with LnDI30 in participants with dyslipidemia (beta = − 0.225, − 0.122, P = 0.035, 0.048 in groups B and D, respectively). Reduced serum SOD levels in individuals with dysglycemia plus dyslipidemia were observed, and a negative association between TG and SOD levels was found (r = − 0.461, P < 0.001). Conclusion TG correlated with both insulin resistance and beta cell function in individuals with dyslipidemia alone. SOD negatively correlated with TG, indicating a close relationship between oxidative stress and glucose-lipid metabolism. Due to the adverse effect of hypertriglyceridemia on insulin sensitivity and islet beta cell function, more attention should be paid to the detection and management of hypertriglyceridemia. |
topic |
Glucose Lipid Diabetes Triglyceride Superoxide dismutase Insulin resistance |
url |
http://link.springer.com/article/10.1186/s12944-020-01303-w |
work_keys_str_mv |
AT mingleima triglycerideisindependentlycorrelatedwithinsulinresistanceandisletbetacellfunctionastudyinpopulationwithdifferentglucoseandlipidmetabolismstates AT haibinliu triglycerideisindependentlycorrelatedwithinsulinresistanceandisletbetacellfunctionastudyinpopulationwithdifferentglucoseandlipidmetabolismstates AT jieyu triglycerideisindependentlycorrelatedwithinsulinresistanceandisletbetacellfunctionastudyinpopulationwithdifferentglucoseandlipidmetabolismstates AT shulihe triglycerideisindependentlycorrelatedwithinsulinresistanceandisletbetacellfunctionastudyinpopulationwithdifferentglucoseandlipidmetabolismstates AT pingpingli triglycerideisindependentlycorrelatedwithinsulinresistanceandisletbetacellfunctionastudyinpopulationwithdifferentglucoseandlipidmetabolismstates AT chunxiaoma triglycerideisindependentlycorrelatedwithinsulinresistanceandisletbetacellfunctionastudyinpopulationwithdifferentglucoseandlipidmetabolismstates AT huabingzhang triglycerideisindependentlycorrelatedwithinsulinresistanceandisletbetacellfunctionastudyinpopulationwithdifferentglucoseandlipidmetabolismstates AT linglingxu triglycerideisindependentlycorrelatedwithinsulinresistanceandisletbetacellfunctionastudyinpopulationwithdifferentglucoseandlipidmetabolismstates AT fanping triglycerideisindependentlycorrelatedwithinsulinresistanceandisletbetacellfunctionastudyinpopulationwithdifferentglucoseandlipidmetabolismstates AT weili triglycerideisindependentlycorrelatedwithinsulinresistanceandisletbetacellfunctionastudyinpopulationwithdifferentglucoseandlipidmetabolismstates AT qisun triglycerideisindependentlycorrelatedwithinsulinresistanceandisletbetacellfunctionastudyinpopulationwithdifferentglucoseandlipidmetabolismstates AT yuxiuli triglycerideisindependentlycorrelatedwithinsulinresistanceandisletbetacellfunctionastudyinpopulationwithdifferentglucoseandlipidmetabolismstates |
_version_ |
1724686331381022720 |
spelling |
doaj-9661656427594a31a9dff35283c70e932020-11-25T03:03:20ZengBMCLipids in Health and Disease1476-511X2020-06-0119111210.1186/s12944-020-01303-wTriglyceride is independently correlated with insulin resistance and islet beta cell function: a study in population with different glucose and lipid metabolism statesMinglei Ma0Haibin Liu1Jie Yu2Shuli He3Pingping Li4Chunxiao Ma5Huabing Zhang6Lingling Xu7Fan Ping8Wei Li9Qi Sun10Yuxiu Li11Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College HospitalDepartment of Basic Physiology, The Health School affiliated with Capital Medical UniversityDepartment of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College HospitalDepartment of Nutrition, Peking Union Medical College HospitalState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College HospitalDepartment of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College HospitalDepartment of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College HospitalDepartment of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College HospitalDepartment of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College HospitalDepartment of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College HospitalAbstract Background Previous studies on the effects of lipotoxicity and oxidative stress on islet beta cell function mainly focused on patients with diabetes, whereas studies on normal glucose tolerance (NGT) are few. The aim of this study was to explore the relationships among triglyceride (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), oxidative stress indicators, insulin resistance, and beta cell function in populations with different glucose and lipid metabolism states. Methods A total of 517 individuals were recruited from a rural community in Beijing, China. Glucose metabolism status was defined according to the results of a 75-g oral glucose tolerance test (OGTT). Dyslipidemia was defined as abnormal TG, HDL-c, or LDL-c levels. The population was divided into four groups: individuals with normal glucose and lipid levels (group A, n = 62); those with dyslipidemia alone (group B, n = 82); those with dysglycemia alone (group C, n = 121); and those with dysglycemia and dyslipidemia (group D, n = 247). Oxidative stress indicators, including superoxide dismutase (SOD), glutathione reductase (GR) and 8-hydroxydeoxyguanosine (8-OHdG), were measured. Homeostasis model assessment of insulin resistance (HOMA-IR) and glucose disposition index (DI30, DI120) were calculated to assess insulin resistance and islet beta cell function, respectively. Stratified multiple linear regression analysis was used to explore relationships between TG, HDL-c, LDL-c, oxidative stress indicators, and insulin resistance (natural log transformation of HOMA-IR, LnHOMA-IR) and beta cell function (natural log transformation of DI30, Ln DI30). Results Compared with the control group, populations with dyslipidemia and/or dysglycemia showed significantly increased insulin resistance. Dyslipidemia aggravated insulin resistance and beta cell dysfunction in individuals with dysglycemia. Stratified regression analysis showed that TG positively correlated with LnHOMA-IR in individuals with normal glucose levels (beta = 0.321, 0.327, P = 0.011, 0.003 in groups A and B, respectively) and negatively correlated with LnDI30 in participants with dyslipidemia (beta = − 0.225, − 0.122, P = 0.035, 0.048 in groups B and D, respectively). Reduced serum SOD levels in individuals with dysglycemia plus dyslipidemia were observed, and a negative association between TG and SOD levels was found (r = − 0.461, P < 0.001). Conclusion TG correlated with both insulin resistance and beta cell function in individuals with dyslipidemia alone. SOD negatively correlated with TG, indicating a close relationship between oxidative stress and glucose-lipid metabolism. Due to the adverse effect of hypertriglyceridemia on insulin sensitivity and islet beta cell function, more attention should be paid to the detection and management of hypertriglyceridemia.http://link.springer.com/article/10.1186/s12944-020-01303-wGlucoseLipidDiabetesTriglycerideSuperoxide dismutaseInsulin resistance |