Omics Approaches Applied to <i>Penicillium chrysogenum</i> and Penicillin Production: Revealing the Secrets of Improved Productivity

Penicillin biosynthesis by <i>Penicillium chrysogenum</i> is one of the best-characterized biological processes from the genetic, molecular, biochemical, and subcellular points of view. Several omics studies have been carried out in this filamentous fungus during the last decade, which h...

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Bibliographic Details
Main Authors: Carlos García-Estrada, Juan F. Martín, Laura Cueto, Carlos Barreiro
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Genes
Subjects:
Online Access:https://www.mdpi.com/2073-4425/11/6/712
Description
Summary:Penicillin biosynthesis by <i>Penicillium chrysogenum</i> is one of the best-characterized biological processes from the genetic, molecular, biochemical, and subcellular points of view. Several omics studies have been carried out in this filamentous fungus during the last decade, which have contributed to gathering a deep knowledge about the molecular mechanisms underlying improved productivity in industrial strains. The information provided by these studies is extremely useful for enhancing the production of penicillin or other bioactive secondary metabolites by means of Biotechnology or Synthetic Biology.
ISSN:2073-4425