Cell Therapy for Parkinson’s Disease
Cell therapy for Parkinson’s disease (PD) began in 1979 with the transplantation of fetal rat dopamine-containing neurons that improved motor abnormalities in the PD rat model with good survival of grafts and axonal outgrowth. Thirty years have passed since the 2 clinical trials using cell transplan...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
SAGE Publishing
2017-09-01
|
Series: | Cell Transplantation |
Online Access: | https://doi.org/10.1177/0963689717735411 |
id |
doaj-9671848be1414831b3720865c5aac78e |
---|---|
record_format |
Article |
spelling |
doaj-9671848be1414831b3720865c5aac78e2020-11-25T03:01:07ZengSAGE PublishingCell Transplantation0963-68971555-38922017-09-012610.1177/0963689717735411Cell Therapy for Parkinson’s DiseaseTakao Yasuhara0Masahiro Kameda1Tatsuya Sasaki2Naoki Tajiri3Isao Date4 Department of Neurological Surgery, Graduate School of Medicine, Okayama University, Okayama, Japan Department of Neurological Surgery, Graduate School of Medicine, Okayama University, Okayama, Japan Department of Neurological Surgery, Graduate School of Medicine, Okayama University, Okayama, Japan Department of Psychology, Graduate School of Psychology, Kibi International University, Okayama, Japan Department of Neurological Surgery, Graduate School of Medicine, Okayama University, Okayama, JapanCell therapy for Parkinson’s disease (PD) began in 1979 with the transplantation of fetal rat dopamine-containing neurons that improved motor abnormalities in the PD rat model with good survival of grafts and axonal outgrowth. Thirty years have passed since the 2 clinical trials using cell transplantation for PD patients were first reported. Recently, cell therapy is expected to develop as a realistic treatment option for PD patients owing to the advancement of biotechnology represented by pluripotent stem cells. Medication using levodopa, surgery including deep brain stimulation, and rehabilitation have all been established as current therapeutic strategies. Strong therapeutic effects have been demonstrated by these treatment methods, but they have been unable to stop the progression of the disease. Fortunately, cell therapy might be a key for true neurorestoration. This review article describes the historical development of cell therapy for PD, the current status of cell therapy, and the future direction of this treatment method.https://doi.org/10.1177/0963689717735411 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Takao Yasuhara Masahiro Kameda Tatsuya Sasaki Naoki Tajiri Isao Date |
spellingShingle |
Takao Yasuhara Masahiro Kameda Tatsuya Sasaki Naoki Tajiri Isao Date Cell Therapy for Parkinson’s Disease Cell Transplantation |
author_facet |
Takao Yasuhara Masahiro Kameda Tatsuya Sasaki Naoki Tajiri Isao Date |
author_sort |
Takao Yasuhara |
title |
Cell Therapy for Parkinson’s Disease |
title_short |
Cell Therapy for Parkinson’s Disease |
title_full |
Cell Therapy for Parkinson’s Disease |
title_fullStr |
Cell Therapy for Parkinson’s Disease |
title_full_unstemmed |
Cell Therapy for Parkinson’s Disease |
title_sort |
cell therapy for parkinson’s disease |
publisher |
SAGE Publishing |
series |
Cell Transplantation |
issn |
0963-6897 1555-3892 |
publishDate |
2017-09-01 |
description |
Cell therapy for Parkinson’s disease (PD) began in 1979 with the transplantation of fetal rat dopamine-containing neurons that improved motor abnormalities in the PD rat model with good survival of grafts and axonal outgrowth. Thirty years have passed since the 2 clinical trials using cell transplantation for PD patients were first reported. Recently, cell therapy is expected to develop as a realistic treatment option for PD patients owing to the advancement of biotechnology represented by pluripotent stem cells. Medication using levodopa, surgery including deep brain stimulation, and rehabilitation have all been established as current therapeutic strategies. Strong therapeutic effects have been demonstrated by these treatment methods, but they have been unable to stop the progression of the disease. Fortunately, cell therapy might be a key for true neurorestoration. This review article describes the historical development of cell therapy for PD, the current status of cell therapy, and the future direction of this treatment method. |
url |
https://doi.org/10.1177/0963689717735411 |
work_keys_str_mv |
AT takaoyasuhara celltherapyforparkinsonsdisease AT masahirokameda celltherapyforparkinsonsdisease AT tatsuyasasaki celltherapyforparkinsonsdisease AT naokitajiri celltherapyforparkinsonsdisease AT isaodate celltherapyforparkinsonsdisease |
_version_ |
1724694800663314432 |