The clinical value of cytokines in chronic fatigue syndrome
Abstract Chronic fatigue syndrome (CFS) is a heterogeneous disorder with uncertain pathogenesis. Without effective therapy, CFS is characterized by disabling fatigue, depression, memory loss, and somatic discomfort. This comprehensive and impartial review aimed to assess the available evidence and e...
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doaj-967f20971f7241c5955e477ecf3c093d2020-11-25T02:49:19ZengBMCJournal of Translational Medicine1479-58762019-06-0117111210.1186/s12967-019-1948-6The clinical value of cytokines in chronic fatigue syndromeTiansong Yang0Yan Yang1Delong Wang2Chaoran Li3Yuanyuan Qu4Jing Guo5Tianyu Shi6Wang Bo7Zhongren Sun8Tetsuya Asakawa9First Affiliated Hospital, Heilongjiang University of Chinese MedicineHeilongjiang University of Chinese MedicineHeilongjiang University of Chinese MedicineHeilongjiang University of Chinese MedicineHeilongjiang University of Chinese MedicineHeilongjiang University of Chinese MedicineHeilongjiang University of Chinese MedicineHeilongjiang University of Chinese MedicineHeilongjiang University of Chinese MedicineDepartment of Neurosurgery, Hamamatsu University School of MedicineAbstract Chronic fatigue syndrome (CFS) is a heterogeneous disorder with uncertain pathogenesis. Without effective therapy, CFS is characterized by disabling fatigue, depression, memory loss, and somatic discomfort. This comprehensive and impartial review aimed to assess the available evidence and examined the potential clinical value of using cytokines for the monitoring of CFS and as targets for the treatment of CFS. Inflammatory reactions and immune modulation are considered to contribute to the pathophysiology of CFS, and it is well documented that cytokines present in both blood and cerebrospinal fluid (CSF) are closely associated with the progression and severity of CFS. However, pathophysiological and methodological limitations prevent using circulating cytokines as independent diagnostic indices. Moreover, there is no evidence to support the use of CSF cytokines as independent diagnostic indices. Nevertheless, a comprehensive evaluation of changes in circulating and CSF cytokines may improve clinical understanding of the pathophysiology of patients with CFS, aiding in the establishment of an appropriate diagnosis. Importantly, the available evidence does not support the value of cytokines as therapeutic targets. We believe that an improved understanding of cytokine-related mechanisms will be helpful to explore new cytokine-related therapeutic targets.http://link.springer.com/article/10.1186/s12967-019-1948-6Chronic fatigue syndromeInflammatory reactionCytokineIndividual diagnosisImmune modulation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tiansong Yang Yan Yang Delong Wang Chaoran Li Yuanyuan Qu Jing Guo Tianyu Shi Wang Bo Zhongren Sun Tetsuya Asakawa |
spellingShingle |
Tiansong Yang Yan Yang Delong Wang Chaoran Li Yuanyuan Qu Jing Guo Tianyu Shi Wang Bo Zhongren Sun Tetsuya Asakawa The clinical value of cytokines in chronic fatigue syndrome Journal of Translational Medicine Chronic fatigue syndrome Inflammatory reaction Cytokine Individual diagnosis Immune modulation |
author_facet |
Tiansong Yang Yan Yang Delong Wang Chaoran Li Yuanyuan Qu Jing Guo Tianyu Shi Wang Bo Zhongren Sun Tetsuya Asakawa |
author_sort |
Tiansong Yang |
title |
The clinical value of cytokines in chronic fatigue syndrome |
title_short |
The clinical value of cytokines in chronic fatigue syndrome |
title_full |
The clinical value of cytokines in chronic fatigue syndrome |
title_fullStr |
The clinical value of cytokines in chronic fatigue syndrome |
title_full_unstemmed |
The clinical value of cytokines in chronic fatigue syndrome |
title_sort |
clinical value of cytokines in chronic fatigue syndrome |
publisher |
BMC |
series |
Journal of Translational Medicine |
issn |
1479-5876 |
publishDate |
2019-06-01 |
description |
Abstract Chronic fatigue syndrome (CFS) is a heterogeneous disorder with uncertain pathogenesis. Without effective therapy, CFS is characterized by disabling fatigue, depression, memory loss, and somatic discomfort. This comprehensive and impartial review aimed to assess the available evidence and examined the potential clinical value of using cytokines for the monitoring of CFS and as targets for the treatment of CFS. Inflammatory reactions and immune modulation are considered to contribute to the pathophysiology of CFS, and it is well documented that cytokines present in both blood and cerebrospinal fluid (CSF) are closely associated with the progression and severity of CFS. However, pathophysiological and methodological limitations prevent using circulating cytokines as independent diagnostic indices. Moreover, there is no evidence to support the use of CSF cytokines as independent diagnostic indices. Nevertheless, a comprehensive evaluation of changes in circulating and CSF cytokines may improve clinical understanding of the pathophysiology of patients with CFS, aiding in the establishment of an appropriate diagnosis. Importantly, the available evidence does not support the value of cytokines as therapeutic targets. We believe that an improved understanding of cytokine-related mechanisms will be helpful to explore new cytokine-related therapeutic targets. |
topic |
Chronic fatigue syndrome Inflammatory reaction Cytokine Individual diagnosis Immune modulation |
url |
http://link.springer.com/article/10.1186/s12967-019-1948-6 |
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