Synthesis of 2’-Modified Nucleotides
We show in this work the development of modified building blocks for the synthesis of nuclease resistant hammerhead ribozymes. These modified monomers retain the 2’-OH which is essential for the activity of these molecules. Our final goal is to generate a catalytic antisense approach with poten...
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| Format: | Article |
| Language: | English |
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MDPI AG
2000-05-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/5/5/727/ |
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Article |
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doaj-968d7865503348d2bf6c8de04de0f36b2020-11-24T21:11:25ZengMDPI AGMolecules1420-30492000-05-015572772910.3390/50500727Synthesis of 2’-Modified NucleotidesAdolfo IribarrenHéctor TorresMariana GalloWe show in this work the development of modified building blocks for the synthesis of nuclease resistant hammerhead ribozymes. These modified monomers retain the 2’-OH which is essential for the activity of these molecules. Our final goal is to generate a catalytic antisense approach with potential application in gene therapy.http://www.mdpi.com/1420-3049/5/5/727/Modified nucleotidesribozymes |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Adolfo Iribarren Héctor Torres Mariana Gallo |
| spellingShingle |
Adolfo Iribarren Héctor Torres Mariana Gallo Synthesis of 2’-Modified Nucleotides Molecules Modified nucleotides ribozymes |
| author_facet |
Adolfo Iribarren Héctor Torres Mariana Gallo |
| author_sort |
Adolfo Iribarren |
| title |
Synthesis of 2’-Modified Nucleotides |
| title_short |
Synthesis of 2’-Modified Nucleotides |
| title_full |
Synthesis of 2’-Modified Nucleotides |
| title_fullStr |
Synthesis of 2’-Modified Nucleotides |
| title_full_unstemmed |
Synthesis of 2’-Modified Nucleotides |
| title_sort |
synthesis of 2ã¢â€â™-modified nucleotides |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2000-05-01 |
| description |
We show in this work the development of modified building blocks for the synthesis of nuclease resistant hammerhead ribozymes. These modified monomers retain the 2’-OH which is essential for the activity of these molecules. Our final goal is to generate a catalytic antisense approach with potential application in gene therapy. |
| topic |
Modified nucleotides ribozymes |
| url |
http://www.mdpi.com/1420-3049/5/5/727/ |
| work_keys_str_mv |
AT adolfoiribarren synthesisof2aaamodifiednucleotides AT haƒactortorres synthesisof2aaamodifiednucleotides AT marianagallo synthesisof2aaamodifiednucleotides |
| _version_ |
1716753463252090880 |