Synthesis of 2’-Modified Nucleotides

We show in this work the development of modified building blocks for the synthesis of nuclease resistant hammerhead ribozymes. These modified monomers retain the 2’-OH which is essential for the activity of these molecules. Our final goal is to generate a catalytic antisense approach with poten...

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Bibliographic Details
Main Authors: Adolfo Iribarren, Héctor Torres, Mariana Gallo
Format: Article
Language:English
Published: MDPI AG 2000-05-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/5/5/727/