Cerebellar Purkinje Cells Generate Highly Correlated Spontaneous Slow-Rate Fluctuations
Cerebellar Purkinje cells (PC) fire action potentials at high, sustained rates. Changes in spike rate that last a few tens of milliseconds encode sensory and behavioral events. Here we investigated spontaneous fluctuations of PC simple spike rate at a slow time scale of the order of 1 s. Simultaneou...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2017-09-01
|
Series: | Frontiers in Neural Circuits |
Subjects: | |
Online Access: | http://journal.frontiersin.org/article/10.3389/fncir.2017.00067/full |
id |
doaj-969f1a903da045519d7bee239b365af0 |
---|---|
record_format |
Article |
spelling |
doaj-969f1a903da045519d7bee239b365af02020-11-24T22:54:29ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102017-09-011110.3389/fncir.2017.00067280128Cerebellar Purkinje Cells Generate Highly Correlated Spontaneous Slow-Rate FluctuationsYing Cao0Yu Liu1Dieter Jaeger2Detlef H. Heck3Department of Anatomy and Neurobiology, University of Tennessee Health Science CenterMemphis, TN, United StatesDepartment of Anatomy and Neurobiology, University of Tennessee Health Science CenterMemphis, TN, United StatesDepartment of Biology, Emory UniversityAtlanta, GA, United StatesDepartment of Anatomy and Neurobiology, University of Tennessee Health Science CenterMemphis, TN, United StatesCerebellar Purkinje cells (PC) fire action potentials at high, sustained rates. Changes in spike rate that last a few tens of milliseconds encode sensory and behavioral events. Here we investigated spontaneous fluctuations of PC simple spike rate at a slow time scale of the order of 1 s. Simultaneous recordings from pairs of PCs that were aligned either along the sagittal or transversal axis of the cerebellar cortex revealed that simple spike rate fluctuations at the 1 s time scale were highly correlated. Each pair of PCs had either a predominantly positive or negative slow-rate correlation, with negative correlations observed only in PC pairs aligned along the transversal axis. Slow-rate correlations were independent of faster rate changes that were correlated with fluid licking behavior. Simultaneous recordings from PCs and cerebellar nuclear (CN) neurons showed that slow-rate fluctuations in PC and CN activity were also highly correlated, but their correlations continually alternated between periods of positive and negative correlation. The functional significance of this new aspect of cerebellar spike activity remains to be determined. Correlated slow-rate fluctuations seem too slow to be involved in the real-time control of ongoing behavior. However, slow-rate fluctuations of PCs converging on the same CN neuron are likely to modulate the excitability of the CN neuron, thus introduce a possible slow modulation of cerebellar output activity.http://journal.frontiersin.org/article/10.3389/fncir.2017.00067/fullrate codingrate correlationcerebellar cortico-nuclear interactionPurkinje cell activityawake mousecerebellar nuclei |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ying Cao Yu Liu Dieter Jaeger Detlef H. Heck |
spellingShingle |
Ying Cao Yu Liu Dieter Jaeger Detlef H. Heck Cerebellar Purkinje Cells Generate Highly Correlated Spontaneous Slow-Rate Fluctuations Frontiers in Neural Circuits rate coding rate correlation cerebellar cortico-nuclear interaction Purkinje cell activity awake mouse cerebellar nuclei |
author_facet |
Ying Cao Yu Liu Dieter Jaeger Detlef H. Heck |
author_sort |
Ying Cao |
title |
Cerebellar Purkinje Cells Generate Highly Correlated Spontaneous Slow-Rate Fluctuations |
title_short |
Cerebellar Purkinje Cells Generate Highly Correlated Spontaneous Slow-Rate Fluctuations |
title_full |
Cerebellar Purkinje Cells Generate Highly Correlated Spontaneous Slow-Rate Fluctuations |
title_fullStr |
Cerebellar Purkinje Cells Generate Highly Correlated Spontaneous Slow-Rate Fluctuations |
title_full_unstemmed |
Cerebellar Purkinje Cells Generate Highly Correlated Spontaneous Slow-Rate Fluctuations |
title_sort |
cerebellar purkinje cells generate highly correlated spontaneous slow-rate fluctuations |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neural Circuits |
issn |
1662-5110 |
publishDate |
2017-09-01 |
description |
Cerebellar Purkinje cells (PC) fire action potentials at high, sustained rates. Changes in spike rate that last a few tens of milliseconds encode sensory and behavioral events. Here we investigated spontaneous fluctuations of PC simple spike rate at a slow time scale of the order of 1 s. Simultaneous recordings from pairs of PCs that were aligned either along the sagittal or transversal axis of the cerebellar cortex revealed that simple spike rate fluctuations at the 1 s time scale were highly correlated. Each pair of PCs had either a predominantly positive or negative slow-rate correlation, with negative correlations observed only in PC pairs aligned along the transversal axis. Slow-rate correlations were independent of faster rate changes that were correlated with fluid licking behavior. Simultaneous recordings from PCs and cerebellar nuclear (CN) neurons showed that slow-rate fluctuations in PC and CN activity were also highly correlated, but their correlations continually alternated between periods of positive and negative correlation. The functional significance of this new aspect of cerebellar spike activity remains to be determined. Correlated slow-rate fluctuations seem too slow to be involved in the real-time control of ongoing behavior. However, slow-rate fluctuations of PCs converging on the same CN neuron are likely to modulate the excitability of the CN neuron, thus introduce a possible slow modulation of cerebellar output activity. |
topic |
rate coding rate correlation cerebellar cortico-nuclear interaction Purkinje cell activity awake mouse cerebellar nuclei |
url |
http://journal.frontiersin.org/article/10.3389/fncir.2017.00067/full |
work_keys_str_mv |
AT yingcao cerebellarpurkinjecellsgeneratehighlycorrelatedspontaneousslowratefluctuations AT yuliu cerebellarpurkinjecellsgeneratehighlycorrelatedspontaneousslowratefluctuations AT dieterjaeger cerebellarpurkinjecellsgeneratehighlycorrelatedspontaneousslowratefluctuations AT detlefhheck cerebellarpurkinjecellsgeneratehighlycorrelatedspontaneousslowratefluctuations |
_version_ |
1725659526235947008 |