Secondary metabolites from the resins of Aloe vera and Commiphora mukul mitigate lipid peroxidation
Oxidative stress is often considered detrimental for cellular processes and damaging for the lipid bi-layer. Counteracting such stresses with the aid of nature-based chemical constituents can be an ideal therapeutic approach. The current study aimed to investigate the chemical constituents of resins...
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doaj-96a8efe5102d4034b3aa265c907e83f92021-09-06T19:40:59ZengSciendoActa Pharmaceutica1846-95582019-09-0169343344110.2478/acph-2019-0027acph-2019-0027Secondary metabolites from the resins of Aloe vera and Commiphora mukul mitigate lipid peroxidationRehman Najeeb Ur0Al-Riyami Samia Ahmed1Hussain Hidayat2Ali Amjad3Khan Abdul Latif4Al-Harrasi Ahmed5Natural & Medical Sciences Reasearch Center, University of Nizwa, Nizwa, Sultanate of OmanNatural & Medical Sciences Reasearch Center, University of Nizwa, Nizwa, Sultanate of OmanNatural & Medical Sciences Reasearch Center, University of Nizwa, Nizwa, Sultanate of OmanNatural & Medical Sciences Reasearch Center, University of Nizwa, Nizwa, Sultanate of OmanNatural & Medical Sciences Reasearch Center, University of Nizwa, Nizwa, Sultanate of OmanNatural & Medical Sciences Reasearch Center, University of Nizwa, Nizwa, Sultanate of OmanOxidative stress is often considered detrimental for cellular processes and damaging for the lipid bi-layer. Counteracting such stresses with the aid of nature-based chemical constituents can be an ideal therapeutic approach. The current study aimed to investigate the chemical constituents of resins derived from the well-known Aloe vera and less known Commiphora mukul trees and their effect in mitigating the lipid peroxidation (LPO) process. The bio-guided isolation of bio-active fractions from both resins afforded 20 chemical constituents (17 from A. vera and 3 from C. mukul). These compounds belonged to anthraquinones, anthraquinone glycosides, quinones, coumarins, polypodane-type terpenoids and benzene derivatives. Major chemical constituents of the resins of A. vera and C. mukul were from the classes of quinones and terpenoids. Feroxidin (4, from A. vera) showed slightly higher inhibition (IC50 = 201.7 ± 0.9 µmol L−1) than myrrhanone C (18, from C. mukul: IC50 = 210.7 ± 0.0 µmol L−1) and methyl 3-(4-hydroxyphenyl) propionate from A. vera (13, IC50 = 232.9 ± 0.2 µmol L−1) compared to the other compounds. Structure-activity relationship showed that the existence of hydroxyl, methoxy and ether groups might play a major role in countering oxidative stress. To the best of our knowledge, anti-LPO activities of compounds 1–4, 14, 18 and 20 are reported for the first time. Such chemical constituents with high anti-lipid peroxidation activity could be helpful in synthesizing candidate drugs.https://doi.org/10.2478/acph-2019-0027aloe veracommiphora mukulanti-lpoferoxidinmyrrhanone c |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rehman Najeeb Ur Al-Riyami Samia Ahmed Hussain Hidayat Ali Amjad Khan Abdul Latif Al-Harrasi Ahmed |
spellingShingle |
Rehman Najeeb Ur Al-Riyami Samia Ahmed Hussain Hidayat Ali Amjad Khan Abdul Latif Al-Harrasi Ahmed Secondary metabolites from the resins of Aloe vera and Commiphora mukul mitigate lipid peroxidation Acta Pharmaceutica aloe vera commiphora mukul anti-lpo feroxidin myrrhanone c |
author_facet |
Rehman Najeeb Ur Al-Riyami Samia Ahmed Hussain Hidayat Ali Amjad Khan Abdul Latif Al-Harrasi Ahmed |
author_sort |
Rehman Najeeb Ur |
title |
Secondary metabolites from the resins of Aloe vera and Commiphora mukul mitigate lipid peroxidation |
title_short |
Secondary metabolites from the resins of Aloe vera and Commiphora mukul mitigate lipid peroxidation |
title_full |
Secondary metabolites from the resins of Aloe vera and Commiphora mukul mitigate lipid peroxidation |
title_fullStr |
Secondary metabolites from the resins of Aloe vera and Commiphora mukul mitigate lipid peroxidation |
title_full_unstemmed |
Secondary metabolites from the resins of Aloe vera and Commiphora mukul mitigate lipid peroxidation |
title_sort |
secondary metabolites from the resins of aloe vera and commiphora mukul mitigate lipid peroxidation |
publisher |
Sciendo |
series |
Acta Pharmaceutica |
issn |
1846-9558 |
publishDate |
2019-09-01 |
description |
Oxidative stress is often considered detrimental for cellular processes and damaging for the lipid bi-layer. Counteracting such stresses with the aid of nature-based chemical constituents can be an ideal therapeutic approach. The current study aimed to investigate the chemical constituents of resins derived from the well-known Aloe vera and less known Commiphora mukul trees and their effect in mitigating the lipid peroxidation (LPO) process. The bio-guided isolation of bio-active fractions from both resins afforded 20 chemical constituents (17 from A. vera and 3 from C. mukul). These compounds belonged to anthraquinones, anthraquinone glycosides, quinones, coumarins, polypodane-type terpenoids and benzene derivatives. Major chemical constituents of the resins of A. vera and C. mukul were from the classes of quinones and terpenoids. Feroxidin (4, from A. vera) showed slightly higher inhibition (IC50 = 201.7 ± 0.9 µmol L−1) than myrrhanone C (18, from C. mukul: IC50 = 210.7 ± 0.0 µmol L−1) and methyl 3-(4-hydroxyphenyl) propionate from A. vera (13, IC50 = 232.9 ± 0.2 µmol L−1) compared to the other compounds. Structure-activity relationship showed that the existence of hydroxyl, methoxy and ether groups might play a major role in countering oxidative stress. To the best of our knowledge, anti-LPO activities of compounds 1–4, 14, 18 and 20 are reported for the first time. Such chemical constituents with high anti-lipid peroxidation activity could be helpful in synthesizing candidate drugs. |
topic |
aloe vera commiphora mukul anti-lpo feroxidin myrrhanone c |
url |
https://doi.org/10.2478/acph-2019-0027 |
work_keys_str_mv |
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