Effects of Bailing capsule combined with irbesartan on oxidative stress, inflammatory response and immune function in patients with diabetic nephropathy

• Main Authors: Zhong Li, Guang-Ming Zhang, Sha Zheng, Jia-Jia Zheng, Yan Zhang, Ping Yuan
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2019-05-01
• Series: Journal of Hainan Medical University
• Subjects: bailing capsule; irbesartan; diabetic nephropathy; oxidative stress; inflammatory response; immune function
• Online Access: http://www.hnykdxxb.com/PDF/201909/08.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To explore the effects of Bailing capsule combined with irbesartan on oxidative stress, inflammatory response and immune function in patients with diabetic nephropathy. Methods: 142 patients with diabetic nephropathy admitted to our hospital from April 2017 to July 2018 were selected as the study subjects. 71 cases in the control group and 71 cases in the observation group were randomly assigned. The renal function, oxidative stress, inflammation and immune indexes of two groups of patients with diabetic nephropathy were compared and analyzed. Results: After treatment, the levels of BUN, SCr, UARE, ROS, AOPPS, TNF-α, CRP and CD8+ of DN patients in both groups decreased significantly compared withthose before the treatment, while the levels of SOD, CD4+, CD4+/CD8+ increased significantly compared with those before the treatment; and the levels of BUN, SCr, UARE, ROS, AOPPS, TNF-α, CRP and CD8+ in the observation group were significantly lower than those in the control group, while the levels of SOD, CD4+, CD4+/CD8+ in the observation group were significantly higher than those in the control group. Conclusions: Bailing capsule combined with irbesartan in the treatment of diabetic nephropathy can effectively improve the renal function, oxidize inflammatory reaction and enhance the immune function of patients, which has clinical significance.