Effects of Bailing capsule combined with irbesartan on oxidative stress, inflammatory response and immune function in patients with diabetic nephropathy
Objective: To explore the effects of Bailing capsule combined with irbesartan on oxidative stress, inflammatory response and immune function in patients with diabetic nephropathy. Methods: 142 patients with diabetic nephropathy admitted to our hospital from April 2017 to July 2018 were selected a...
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doaj-96ccb31652fe4acdb8d7792f7de9b2a72020-11-25T01:52:37ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12371007-12372019-05-012593336Effects of Bailing capsule combined with irbesartan on oxidative stress, inflammatory response and immune function in patients with diabetic nephropathyZhong Li0Guang-Ming Zhang1Sha Zheng2Jia-Jia Zheng3Yan Zhang4Ping Yuan5Nephrology Department, Chengdu Xindu District People's Hospital, Chengdu 610500, Sichuan, ChinaNephrology Department, Chengdu Xindu District People's Hospital, Chengdu 610500, Sichuan, ChinaNephrology Department, Chengdu Xindu District People's Hospital, Chengdu 610500, Sichuan, ChinaNephrology Department, Chengdu Xindu District People's Hospital, Chengdu 610500, Sichuan, ChinaNephrology Department, Chengdu Xindu District People's Hospital, Chengdu 610500, Sichuan, ChinaDepartment of Health Statistics, West China School of Public Health, Sichuan University,Chengdu 610061 ChinaObjective: To explore the effects of Bailing capsule combined with irbesartan on oxidative stress, inflammatory response and immune function in patients with diabetic nephropathy. Methods: 142 patients with diabetic nephropathy admitted to our hospital from April 2017 to July 2018 were selected as the study subjects. 71 cases in the control group and 71 cases in the observation group were randomly assigned. The renal function, oxidative stress, inflammation and immune indexes of two groups of patients with diabetic nephropathy were compared and analyzed. Results: After treatment, the levels of BUN, SCr, UARE, ROS, AOPPS, TNF-α, CRP and CD8+ of DN patients in both groups decreased significantly compared withthose before the treatment, while the levels of SOD, CD4+, CD4+/CD8+ increased significantly compared with those before the treatment; and the levels of BUN, SCr, UARE, ROS, AOPPS, TNF-α, CRP and CD8+ in the observation group were significantly lower than those in the control group, while the levels of SOD, CD4+, CD4+/CD8+ in the observation group were significantly higher than those in the control group. Conclusions: Bailing capsule combined with irbesartan in the treatment of diabetic nephropathy can effectively improve the renal function, oxidize inflammatory reaction and enhance the immune function of patients, which has clinical significance. http://www.hnykdxxb.com/PDF/201909/08.pdfbailing capsuleirbesartandiabetic nephropathyoxidative stressinflammatory responseimmune function |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhong Li Guang-Ming Zhang Sha Zheng Jia-Jia Zheng Yan Zhang Ping Yuan |
spellingShingle |
Zhong Li Guang-Ming Zhang Sha Zheng Jia-Jia Zheng Yan Zhang Ping Yuan Effects of Bailing capsule combined with irbesartan on oxidative stress, inflammatory response and immune function in patients with diabetic nephropathy Journal of Hainan Medical University bailing capsule irbesartan diabetic nephropathy oxidative stress inflammatory response immune function |
author_facet |
Zhong Li Guang-Ming Zhang Sha Zheng Jia-Jia Zheng Yan Zhang Ping Yuan |
author_sort |
Zhong Li |
title |
Effects of Bailing capsule combined with irbesartan on oxidative stress, inflammatory response and immune function in patients with diabetic nephropathy |
title_short |
Effects of Bailing capsule combined with irbesartan on oxidative stress, inflammatory response and immune function in patients with diabetic nephropathy |
title_full |
Effects of Bailing capsule combined with irbesartan on oxidative stress, inflammatory response and immune function in patients with diabetic nephropathy |
title_fullStr |
Effects of Bailing capsule combined with irbesartan on oxidative stress, inflammatory response and immune function in patients with diabetic nephropathy |
title_full_unstemmed |
Effects of Bailing capsule combined with irbesartan on oxidative stress, inflammatory response and immune function in patients with diabetic nephropathy |
title_sort |
effects of bailing capsule combined with irbesartan on oxidative stress, inflammatory response and immune function in patients with diabetic nephropathy |
publisher |
Editorial Board of Journal of Hainan Medical University |
series |
Journal of Hainan Medical University |
issn |
1007-1237 1007-1237 |
publishDate |
2019-05-01 |
description |
Objective: To explore the effects of Bailing capsule combined with irbesartan on oxidative
stress, inflammatory response and immune function in patients with diabetic nephropathy.
Methods: 142 patients with diabetic nephropathy admitted to our hospital from April 2017 to
July 2018 were selected as the study subjects. 71 cases in the control group and 71 cases in the
observation group were randomly assigned. The renal function, oxidative stress, inflammation
and immune indexes of two groups of patients with diabetic nephropathy were compared
and analyzed. Results: After treatment, the levels of BUN, SCr, UARE, ROS, AOPPS, TNF-α, CRP and CD8+ of DN patients in both groups decreased significantly compared withthose before the treatment, while the levels of SOD, CD4+, CD4+/CD8+ increased significantly
compared with those before the treatment; and the levels of BUN, SCr, UARE, ROS, AOPPS,
TNF-α, CRP and CD8+ in the observation group were significantly lower than those in the
control group, while the levels of SOD, CD4+, CD4+/CD8+ in the observation group were
significantly higher than those in the control group. Conclusions: Bailing capsule combined
with irbesartan in the treatment of diabetic nephropathy can effectively improve the renal
function, oxidize inflammatory reaction and enhance the immune function of patients, which
has clinical significance.
|
topic |
bailing capsule irbesartan diabetic nephropathy oxidative stress inflammatory response immune function |
url |
http://www.hnykdxxb.com/PDF/201909/08.pdf |
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