A five-year longitudinal study of the relation between end-stage kidney disease as the outcomes
Abstract Background Patients with end-stage kidney disease (ESKD) are required to undergo consecutive time-based blood and biochemical tests to determine the progression of the disease according to changes in their blood and biochemical data. This study employed a random intercept model to investiga...
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doaj-96cd5802a5e740439fbdced8c2fc40022020-11-25T02:29:59ZengBMCBMC Nephrology1471-23692020-04-0121111010.1186/s12882-020-01795-9A five-year longitudinal study of the relation between end-stage kidney disease as the outcomesHsiu-Lan Li0Pei-Hui Tai1Yi-Ting Hwang2Shih-Wei Lin3Graduate Institute of Business and Management, Chang Gung UniversityDepartment of Nursing, En Cku Kong HospitalDepartment of Statistics, National Taipei UniversityDepartment of Information Management, Chang Gung UniversityAbstract Background Patients with end-stage kidney disease (ESKD) are required to undergo consecutive time-based blood and biochemical tests to determine the progression of the disease according to changes in their blood and biochemical data. This study employed a random intercept model to investigate whether time-based blood and biochemical data present any notable clinical meaning that can be used to track disease progression. Methods This study conducted a retrospective analysis on the dialytic data of 148 patients with ESKD, who received hemodialysis between January 2005 and December 2015. The patients were all at least 20 years old, and the data used included patient demographic information and results for at least 60 blood and biochemical tests. A random intercept model was used to analyze the relationships among blood and biochemical test results, explanatory variables of patient comorbidities, and time. Results The age range of patients was between 33 and 98 years, with an average of 66.1 years and those over 65 years old comprising 51.3% (n = 76) of the total. Furthermore, hypertension was found to be the most common comorbidity among patients (87.2%, n = 129), followed by anemia (48.6%, n = 72), diabetes (47.3%, n = 70), dyslipidemia (19.6%, n = 29), and peptic ulcer (19.6%, n = 29). Coronary atherosclerotic heart disease is a comorbidity that can serve as a strong and independent marker for prognosis in patients with ESKD. Serum creatinine level can serve as an alternative indicator because patients with ESKD and comorbid diabetes may exhibit increased creatinine levels. Conclusions The results of a parameter estimation for longitudinal data analysis suggested that comorbidity and time were critical variables influencing blood and biochemical test results. Furthermore, WBC and HBC, HCT, albumin, protein, and creatinine levels were recognized as variables of critical significance. The results obtained in this study indicate that multimorbidity increases the treatment burden on patients, leading to polypharmacy. For this reason, comprehensive care and treatment of ESKD cannot rely solely on data from one single time point; instead, longitudinal analysis and other data that can affect patient prognosis must also be considered.http://link.springer.com/article/10.1186/s12882-020-01795-9End-stage kidney diseaseEnd-stage renal diseaseLongitudinal StudyComorbidity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hsiu-Lan Li Pei-Hui Tai Yi-Ting Hwang Shih-Wei Lin |
spellingShingle |
Hsiu-Lan Li Pei-Hui Tai Yi-Ting Hwang Shih-Wei Lin A five-year longitudinal study of the relation between end-stage kidney disease as the outcomes BMC Nephrology End-stage kidney disease End-stage renal disease Longitudinal Study Comorbidity |
author_facet |
Hsiu-Lan Li Pei-Hui Tai Yi-Ting Hwang Shih-Wei Lin |
author_sort |
Hsiu-Lan Li |
title |
A five-year longitudinal study of the relation between end-stage kidney disease as the outcomes |
title_short |
A five-year longitudinal study of the relation between end-stage kidney disease as the outcomes |
title_full |
A five-year longitudinal study of the relation between end-stage kidney disease as the outcomes |
title_fullStr |
A five-year longitudinal study of the relation between end-stage kidney disease as the outcomes |
title_full_unstemmed |
A five-year longitudinal study of the relation between end-stage kidney disease as the outcomes |
title_sort |
five-year longitudinal study of the relation between end-stage kidney disease as the outcomes |
publisher |
BMC |
series |
BMC Nephrology |
issn |
1471-2369 |
publishDate |
2020-04-01 |
description |
Abstract Background Patients with end-stage kidney disease (ESKD) are required to undergo consecutive time-based blood and biochemical tests to determine the progression of the disease according to changes in their blood and biochemical data. This study employed a random intercept model to investigate whether time-based blood and biochemical data present any notable clinical meaning that can be used to track disease progression. Methods This study conducted a retrospective analysis on the dialytic data of 148 patients with ESKD, who received hemodialysis between January 2005 and December 2015. The patients were all at least 20 years old, and the data used included patient demographic information and results for at least 60 blood and biochemical tests. A random intercept model was used to analyze the relationships among blood and biochemical test results, explanatory variables of patient comorbidities, and time. Results The age range of patients was between 33 and 98 years, with an average of 66.1 years and those over 65 years old comprising 51.3% (n = 76) of the total. Furthermore, hypertension was found to be the most common comorbidity among patients (87.2%, n = 129), followed by anemia (48.6%, n = 72), diabetes (47.3%, n = 70), dyslipidemia (19.6%, n = 29), and peptic ulcer (19.6%, n = 29). Coronary atherosclerotic heart disease is a comorbidity that can serve as a strong and independent marker for prognosis in patients with ESKD. Serum creatinine level can serve as an alternative indicator because patients with ESKD and comorbid diabetes may exhibit increased creatinine levels. Conclusions The results of a parameter estimation for longitudinal data analysis suggested that comorbidity and time were critical variables influencing blood and biochemical test results. Furthermore, WBC and HBC, HCT, albumin, protein, and creatinine levels were recognized as variables of critical significance. The results obtained in this study indicate that multimorbidity increases the treatment burden on patients, leading to polypharmacy. For this reason, comprehensive care and treatment of ESKD cannot rely solely on data from one single time point; instead, longitudinal analysis and other data that can affect patient prognosis must also be considered. |
topic |
End-stage kidney disease End-stage renal disease Longitudinal Study Comorbidity |
url |
http://link.springer.com/article/10.1186/s12882-020-01795-9 |
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