Increased prevalence of overweight and obesity in children with X-linked hypophosphatemia
Background/aim: X-linked hypophosphatemia (XLH) is a rare disease characterized by low phosphate levels. Scientific evidence points to a link between h ypophosphatemia and obesity in general population. The aim of our longitudinal observational study was to investigate the prevalence of obesity and...
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Bioscientifica
2020-02-01
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Series: | Endocrine Connections |
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Online Access: | https://ec.bioscientifica.com/view/journals/ec/9/2/EC-19-0481.xml |
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doaj-96d17c4323c4493fab48a127761405cb |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Volha V Zhukouskaya Anya Rothenbuhler Annamaria Colao Carolina Di Somma Peter Kamenický Séverine Trabado Dominique Prié Christelle Audrain Anna Barosi Christèle Kyheng Anne-Sophie Lambert Agnès Linglart |
spellingShingle |
Volha V Zhukouskaya Anya Rothenbuhler Annamaria Colao Carolina Di Somma Peter Kamenický Séverine Trabado Dominique Prié Christelle Audrain Anna Barosi Christèle Kyheng Anne-Sophie Lambert Agnès Linglart Increased prevalence of overweight and obesity in children with X-linked hypophosphatemia Endocrine Connections x-linked hypophosphatemia rickets phosphorus overweight obesity |
author_facet |
Volha V Zhukouskaya Anya Rothenbuhler Annamaria Colao Carolina Di Somma Peter Kamenický Séverine Trabado Dominique Prié Christelle Audrain Anna Barosi Christèle Kyheng Anne-Sophie Lambert Agnès Linglart |
author_sort |
Volha V Zhukouskaya |
title |
Increased prevalence of overweight and obesity in children with X-linked hypophosphatemia |
title_short |
Increased prevalence of overweight and obesity in children with X-linked hypophosphatemia |
title_full |
Increased prevalence of overweight and obesity in children with X-linked hypophosphatemia |
title_fullStr |
Increased prevalence of overweight and obesity in children with X-linked hypophosphatemia |
title_full_unstemmed |
Increased prevalence of overweight and obesity in children with X-linked hypophosphatemia |
title_sort |
increased prevalence of overweight and obesity in children with x-linked hypophosphatemia |
publisher |
Bioscientifica |
series |
Endocrine Connections |
issn |
2049-3614 2049-3614 |
publishDate |
2020-02-01 |
description |
Background/aim: X-linked hypophosphatemia (XLH) is a rare disease characterized by low phosphate levels. Scientific evidence points to a link between h ypophosphatemia and obesity in general population. The aim of our longitudinal observational study was to investigate the prevalence of obesity and associated factors in a large cohort of children with XLH.
Patients/methods: We studied 172 XLH-children 5–20 years of age (113 girls/59 boys). Anthropometric parameters (weight, height, and BMI) were collected at birth and during follow-up at mean ages of 5.3, 8.2, 11.3, and 15.9 years (groups 1, 2, 3, and 4, respectively). In each group, subjects were classified based on International Obesity Taskforce (IOTF) cut off values of BMI for age and sex as overwe ight or obese (IOTF 25–30 or ≥30 kg/m2, respectively).
Results: In each age-group, almost 1/3 of XLH-patients were classified a s overweight or obese (29.4, 28.7, 27.5, and 36.7% in groups 1, 2, 3, and 4, respectively). Children without a XLH-family history had higher BMI-IOTF at every point of follow-up, compared to those with positive XLH-family history. Similarly, higher BMI-IOTF wa s significantly associated with treatment duration (23.3 ± 4.4 vs 23.8 ± 3.8 vs 25.2 ± 4.5 kg/m2, for subjects with treatment duration of <5, 5–10 and >10 years, respectively, P for trend = 0.025). Multiple regression analysis confirmed an association of treatment durati on and lack of XLH-family history with higher BMI-IOTF.
Conclusion: One out of three of XLH-children have phenotypically unfavourable metabolic profile expressed as increased prevalence of overweight or obesi ty in comparison to general population. Both the lack of XLH family history and the duration of treatment increase the risk of higher BMI-IOTF. BMI should be carefully monitored in children, and later in adults, with XLH.
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topic |
x-linked hypophosphatemia rickets phosphorus overweight obesity |
url |
https://ec.bioscientifica.com/view/journals/ec/9/2/EC-19-0481.xml |
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doaj-96d17c4323c4493fab48a127761405cb2020-11-25T00:01:31ZengBioscientificaEndocrine Connections2049-36142049-36142020-02-0192144153https://doi.org/10.1530/EC-19-0481Increased prevalence of overweight and obesity in children with X-linked hypophosphatemiaVolha V Zhukouskaya0Anya Rothenbuhler1Annamaria Colao2Carolina Di Somma3Peter Kamenický4Séverine Trabado5Dominique Prié6Christelle Audrain7Anna Barosi8Christèle Kyheng9Anne-Sophie Lambert10Agnès Linglart11APHP, Reference Center for Rare Disorders of the Calcium and Phosphate Metabolism, FilièreOSCAR and Platform of Expertise for Rare Diseases Paris-Saclay, Bicêtre Paris-Saclay Hospital, Le Kremlin-Bicêtre, France; Division of Endocrinology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, ItalyAPHP, Reference Center for Rare Disorders of the Calcium and Phosphate Metabolism, FilièreOSCAR and Platform of Expertise for Rare Diseases Paris-Saclay, Bicêtre Paris-Saclay Hospital, Le Kremlin-Bicêtre, France; APHP, Department of Endocrinology and Diabetology for Children, Bicêtre Paris Saclay Hospital, Le Kremlin-Bicêtre, FranceDivision of Endocrinology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, ItalyDivision of Endocrinology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy; IRCCS SDN, Naples, ItalyAPHP, Reference Center for Rare Disorders of the Calcium and Phosphate Metabolism, FilièreOSCAR and Platform of Expertise for Rare Diseases Paris-Saclay, Bicêtre Paris-Saclay Hospital, Le Kremlin-Bicêtre, France; APHP, Department of Endocrinology and Reproductive Diseases, Bicêtre Paris-Saclay Hospital, Le Kremlin-Bicêtre, France; Paris Sud – Paris Saclay University, Faculté de Médecine, Le Kremlin-Bicêtre, FranceParis Sud – Paris Saclay University, Faculté de Médecine, Le Kremlin-Bicêtre, France; APHP, Department of Molecular Genetics, Pharmacogenetics and Hormonology, Bicêtre Paris-Saclay Hospital, Le Kremlin-Bicêtre, FranceUniversité Paris V, Faculté de Médecine, Paris, France; Hôpital Necker EnfantsMalades APHP, INSERM U1151, Paris, FranceAPHP, Reference Center for Rare Disorders of the Calcium and Phosphate Metabolism, FilièreOSCAR and Platform of Expertise for Rare Diseases Paris-Saclay, Bicêtre Paris-Saclay Hospital, Le Kremlin-Bicêtre, FranceAPHP, Reference Center for Rare Disorders of the Calcium and Phosphate Metabolism, FilièreOSCAR and Platform of Expertise for Rare Diseases Paris-Saclay, Bicêtre Paris-Saclay Hospital, Le Kremlin-Bicêtre, FranceAPHP, Department of Adolescent Medicine, Bicêtre Paris Saclay Hospital, Le Kremlin-Bicêtre, FranceAPHP, Reference Center for Rare Disorders of the Calcium and Phosphate Metabolism, FilièreOSCAR and Platform of Expertise for Rare Diseases Paris-Saclay, Bicêtre Paris-Saclay Hospital, Le Kremlin-Bicêtre, France; APHP, Department of Endocrinology and Diabetology for Children, Bicêtre Paris Saclay Hospital, Le Kremlin-Bicêtre, France; APHP, Department of Adolescent Medicine, Bicêtre Paris Saclay Hospital, Le Kremlin-Bicêtre, FranceAPHP, Reference Center for Rare Disorders of the Calcium and Phosphate Metabolism, FilièreOSCAR and Platform of Expertise for Rare Diseases Paris-Saclay, Bicêtre Paris-Saclay Hospital, Le Kremlin-Bicêtre, France; APHP, Department of Endocrinology and Diabetology for Children, Bicêtre Paris Saclay Hospital, Le Kremlin-Bicêtre, France; Paris Sud – Paris Saclay University, Faculté de Médecine, Le Kremlin-Bicêtre, FranceBackground/aim: X-linked hypophosphatemia (XLH) is a rare disease characterized by low phosphate levels. Scientific evidence points to a link between h ypophosphatemia and obesity in general population. The aim of our longitudinal observational study was to investigate the prevalence of obesity and associated factors in a large cohort of children with XLH. Patients/methods: We studied 172 XLH-children 5–20 years of age (113 girls/59 boys). Anthropometric parameters (weight, height, and BMI) were collected at birth and during follow-up at mean ages of 5.3, 8.2, 11.3, and 15.9 years (groups 1, 2, 3, and 4, respectively). In each group, subjects were classified based on International Obesity Taskforce (IOTF) cut off values of BMI for age and sex as overwe ight or obese (IOTF 25–30 or ≥30 kg/m2, respectively). Results: In each age-group, almost 1/3 of XLH-patients were classified a s overweight or obese (29.4, 28.7, 27.5, and 36.7% in groups 1, 2, 3, and 4, respectively). Children without a XLH-family history had higher BMI-IOTF at every point of follow-up, compared to those with positive XLH-family history. Similarly, higher BMI-IOTF wa s significantly associated with treatment duration (23.3 ± 4.4 vs 23.8 ± 3.8 vs 25.2 ± 4.5 kg/m2, for subjects with treatment duration of <5, 5–10 and >10 years, respectively, P for trend = 0.025). Multiple regression analysis confirmed an association of treatment durati on and lack of XLH-family history with higher BMI-IOTF. Conclusion: One out of three of XLH-children have phenotypically unfavourable metabolic profile expressed as increased prevalence of overweight or obesi ty in comparison to general population. Both the lack of XLH family history and the duration of treatment increase the risk of higher BMI-IOTF. BMI should be carefully monitored in children, and later in adults, with XLH. https://ec.bioscientifica.com/view/journals/ec/9/2/EC-19-0481.xmlx-linked hypophosphatemiaricketsphosphorusoverweightobesity |