Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling

Here Kumar et al. show that increased intestinal permeability reduces hepatic de novo lipogenesis, affecting plasma membrane fluidity and lifespan of RBCs, and the resulting increase in iron levels promotes bacterial growth. This mechanism may explain the increased risk of sepsis associated with inf...

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Main Authors:	Manish Kumar, Aralia Leon Coria, Steve Cornick, Björn Petri, Shyamchand Mayengbam, Humberto B. Jijon, France Moreau, Jane Shearer, Kris Chadee
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-14182-2

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spelling	doaj-96d4615ce4ea4d449b6fdbc7f7f39a952021-05-11T08:00:55ZengNature Publishing GroupNature Communications2041-17232020-01-0111111510.1038/s41467-019-14182-2Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recyclingManish Kumar0Aralia Leon Coria1Steve Cornick2Björn Petri3Shyamchand Mayengbam4Humberto B. Jijon5France Moreau6Jane Shearer7Kris Chadee8Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary Health Sciences CentreDepartment of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary Health Sciences CentreDepartment of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary Health Sciences CentreDepartment of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary Health Sciences CentreFaculty of Kinesiology, University of CalgaryInflammatory Bowel Disease Unit, Division of Gastroenterology and Hepatology, Cumming School of Medicine, University of CalgaryDepartment of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary Health Sciences CentreFaculty of Kinesiology, University of CalgaryDepartment of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary Health Sciences CentreHere Kumar et al. show that increased intestinal permeability reduces hepatic de novo lipogenesis, affecting plasma membrane fluidity and lifespan of RBCs, and the resulting increase in iron levels promotes bacterial growth. This mechanism may explain the increased risk of sepsis associated with inflammatory bowel disease.https://doi.org/10.1038/s41467-019-14182-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Manish Kumar Aralia Leon Coria Steve Cornick Björn Petri Shyamchand Mayengbam Humberto B. Jijon France Moreau Jane Shearer Kris Chadee
spellingShingle	Manish Kumar Aralia Leon Coria Steve Cornick Björn Petri Shyamchand Mayengbam Humberto B. Jijon France Moreau Jane Shearer Kris Chadee Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling Nature Communications
author_facet	Manish Kumar Aralia Leon Coria Steve Cornick Björn Petri Shyamchand Mayengbam Humberto B. Jijon France Moreau Jane Shearer Kris Chadee
author_sort	Manish Kumar
title	Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling
title_short	Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling
title_full	Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling
title_fullStr	Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling
title_full_unstemmed	Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling
title_sort	increased intestinal permeability exacerbates sepsis through reduced hepatic scd-1 activity and dysregulated iron recycling
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-01-01
description	Here Kumar et al. show that increased intestinal permeability reduces hepatic de novo lipogenesis, affecting plasma membrane fluidity and lifespan of RBCs, and the resulting increase in iron levels promotes bacterial growth. This mechanism may explain the increased risk of sepsis associated with inflammatory bowel disease.
url	https://doi.org/10.1038/s41467-019-14182-2
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Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling

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