Third follow-up of the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) cohort investigating determinants of cognitive, physical, and psychosocial wellbeing among the oldest old: the CAIDE85+ study protocol
Abstract Background The oldest old is the fastest growing age group worldwide and the most prone to severe disability, especially in relation to loss of cognitive function. Improving our understanding of the predictors of cognitive, physical and psychosocial wellbeing among the oldest old can result...
Main Authors: | , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2020-07-01
|
Series: | BMC Geriatrics |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12877-020-01617-5 |
id |
doaj-96d82da5ee7a4970a03a928c2fd1f40b |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mariagnese Barbera Jenni Kulmala Inna Lisko Eija Pietilä Anna Rosenberg Ilona Hallikainen Merja Hallikainen Tiina Laatikainen Jenni Lehtisalo Elisa Neuvonen Minna Rusanen Hilkka Soininen Jaakko Tuomilehto Tiia Ngandu Alina Solomon Miia Kivipelto |
spellingShingle |
Mariagnese Barbera Jenni Kulmala Inna Lisko Eija Pietilä Anna Rosenberg Ilona Hallikainen Merja Hallikainen Tiina Laatikainen Jenni Lehtisalo Elisa Neuvonen Minna Rusanen Hilkka Soininen Jaakko Tuomilehto Tiia Ngandu Alina Solomon Miia Kivipelto Third follow-up of the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) cohort investigating determinants of cognitive, physical, and psychosocial wellbeing among the oldest old: the CAIDE85+ study protocol BMC Geriatrics Ageing CAIDE Cognitive decline Dementia Disability Longevity |
author_facet |
Mariagnese Barbera Jenni Kulmala Inna Lisko Eija Pietilä Anna Rosenberg Ilona Hallikainen Merja Hallikainen Tiina Laatikainen Jenni Lehtisalo Elisa Neuvonen Minna Rusanen Hilkka Soininen Jaakko Tuomilehto Tiia Ngandu Alina Solomon Miia Kivipelto |
author_sort |
Mariagnese Barbera |
title |
Third follow-up of the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) cohort investigating determinants of cognitive, physical, and psychosocial wellbeing among the oldest old: the CAIDE85+ study protocol |
title_short |
Third follow-up of the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) cohort investigating determinants of cognitive, physical, and psychosocial wellbeing among the oldest old: the CAIDE85+ study protocol |
title_full |
Third follow-up of the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) cohort investigating determinants of cognitive, physical, and psychosocial wellbeing among the oldest old: the CAIDE85+ study protocol |
title_fullStr |
Third follow-up of the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) cohort investigating determinants of cognitive, physical, and psychosocial wellbeing among the oldest old: the CAIDE85+ study protocol |
title_full_unstemmed |
Third follow-up of the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) cohort investigating determinants of cognitive, physical, and psychosocial wellbeing among the oldest old: the CAIDE85+ study protocol |
title_sort |
third follow-up of the cardiovascular risk factors, aging and dementia (caide) cohort investigating determinants of cognitive, physical, and psychosocial wellbeing among the oldest old: the caide85+ study protocol |
publisher |
BMC |
series |
BMC Geriatrics |
issn |
1471-2318 |
publishDate |
2020-07-01 |
description |
Abstract Background The oldest old is the fastest growing age group worldwide and the most prone to severe disability, especially in relation to loss of cognitive function. Improving our understanding of the predictors of cognitive, physical and psychosocial wellbeing among the oldest old can result in substantial benefits for the individuals and for the society as a whole. The Cardiovascular Risk Factors, Aging and Dementia (CAIDE) study investigated risk factors and determinants of cognitive impairment in a population-based longitudinal cohort, which was first examined between 1972 and 1992, when individuals were in their midlife, and re-assessed in 1998 and 2005–2009. Most of the study participants are currently aged 85 years or older. We aim to re-examine the cohort’s survivors and gain further insights on the mechanisms underlying both cognitive and overall healthy ageing at old age. Methods CAIDE85+ is the third follow-up of the CAIDE study participants. All individuals still alive and living in the Kuopio and Joensuu areas of Eastern Finland, from the original CAIDE cohort (two random samples, N = 2000 + ~ 900), will be invited to a re-examination. The assessment includes self-reported data related to basic demographics and lifestyle, as well as psychosocial and physical health status. Cognitive and physical evaluations are also conducted. Blood biomarkers relevant for dementia and ageing are assessed. Primary outcomes are the measurements related to cognition and daily life functioning (CERAD, Trail Making Test-A, Letter-Digit Substitution Test, Clinical Dementia Rating and Activities of Daily Living). Secondary endpoints of the study are outcomes related to physical health status, psychosocial wellbeing, as well as age-related health indicators. Discussion Through a follow-up of more than 40 years, CAIDE85+ will provide invaluable information on the risk and protective factors that contribute to cognitive and physical health, as well as ageing and longevity. Study registration The present study protocol has been registered at https://clinicaltrials.gov/ (registration nr NCT03938727 , date 03.05.2019). |
topic |
Ageing CAIDE Cognitive decline Dementia Disability Longevity |
url |
http://link.springer.com/article/10.1186/s12877-020-01617-5 |
work_keys_str_mv |
AT mariagnesebarbera thirdfollowupofthecardiovascularriskfactorsaginganddementiacaidecohortinvestigatingdeterminantsofcognitivephysicalandpsychosocialwellbeingamongtheoldestoldthecaide85studyprotocol AT jennikulmala thirdfollowupofthecardiovascularriskfactorsaginganddementiacaidecohortinvestigatingdeterminantsofcognitivephysicalandpsychosocialwellbeingamongtheoldestoldthecaide85studyprotocol AT innalisko thirdfollowupofthecardiovascularriskfactorsaginganddementiacaidecohortinvestigatingdeterminantsofcognitivephysicalandpsychosocialwellbeingamongtheoldestoldthecaide85studyprotocol AT eijapietila thirdfollowupofthecardiovascularriskfactorsaginganddementiacaidecohortinvestigatingdeterminantsofcognitivephysicalandpsychosocialwellbeingamongtheoldestoldthecaide85studyprotocol AT annarosenberg thirdfollowupofthecardiovascularriskfactorsaginganddementiacaidecohortinvestigatingdeterminantsofcognitivephysicalandpsychosocialwellbeingamongtheoldestoldthecaide85studyprotocol AT ilonahallikainen thirdfollowupofthecardiovascularriskfactorsaginganddementiacaidecohortinvestigatingdeterminantsofcognitivephysicalandpsychosocialwellbeingamongtheoldestoldthecaide85studyprotocol AT merjahallikainen thirdfollowupofthecardiovascularriskfactorsaginganddementiacaidecohortinvestigatingdeterminantsofcognitivephysicalandpsychosocialwellbeingamongtheoldestoldthecaide85studyprotocol AT tiinalaatikainen thirdfollowupofthecardiovascularriskfactorsaginganddementiacaidecohortinvestigatingdeterminantsofcognitivephysicalandpsychosocialwellbeingamongtheoldestoldthecaide85studyprotocol AT jennilehtisalo thirdfollowupofthecardiovascularriskfactorsaginganddementiacaidecohortinvestigatingdeterminantsofcognitivephysicalandpsychosocialwellbeingamongtheoldestoldthecaide85studyprotocol AT elisaneuvonen thirdfollowupofthecardiovascularriskfactorsaginganddementiacaidecohortinvestigatingdeterminantsofcognitivephysicalandpsychosocialwellbeingamongtheoldestoldthecaide85studyprotocol AT minnarusanen thirdfollowupofthecardiovascularriskfactorsaginganddementiacaidecohortinvestigatingdeterminantsofcognitivephysicalandpsychosocialwellbeingamongtheoldestoldthecaide85studyprotocol AT hilkkasoininen thirdfollowupofthecardiovascularriskfactorsaginganddementiacaidecohortinvestigatingdeterminantsofcognitivephysicalandpsychosocialwellbeingamongtheoldestoldthecaide85studyprotocol AT jaakkotuomilehto thirdfollowupofthecardiovascularriskfactorsaginganddementiacaidecohortinvestigatingdeterminantsofcognitivephysicalandpsychosocialwellbeingamongtheoldestoldthecaide85studyprotocol AT tiiangandu thirdfollowupofthecardiovascularriskfactorsaginganddementiacaidecohortinvestigatingdeterminantsofcognitivephysicalandpsychosocialwellbeingamongtheoldestoldthecaide85studyprotocol AT alinasolomon thirdfollowupofthecardiovascularriskfactorsaginganddementiacaidecohortinvestigatingdeterminantsofcognitivephysicalandpsychosocialwellbeingamongtheoldestoldthecaide85studyprotocol AT miiakivipelto thirdfollowupofthecardiovascularriskfactorsaginganddementiacaidecohortinvestigatingdeterminantsofcognitivephysicalandpsychosocialwellbeingamongtheoldestoldthecaide85studyprotocol |
_version_ |
1724455665727963136 |
spelling |
doaj-96d82da5ee7a4970a03a928c2fd1f40b2020-11-25T03:59:05ZengBMCBMC Geriatrics1471-23182020-07-012011910.1186/s12877-020-01617-5Third follow-up of the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) cohort investigating determinants of cognitive, physical, and psychosocial wellbeing among the oldest old: the CAIDE85+ study protocolMariagnese Barbera0Jenni Kulmala1Inna Lisko2Eija Pietilä3Anna Rosenberg4Ilona Hallikainen5Merja Hallikainen6Tiina Laatikainen7Jenni Lehtisalo8Elisa Neuvonen9Minna Rusanen10Hilkka Soininen11Jaakko Tuomilehto12Tiia Ngandu13Alina Solomon14Miia Kivipelto15Institute of Clinical Medicine, Department of Neurology, University of Eastern FinlandPublic Health Promotion Unit, Finnish Institute for Health and WelfareDivision of Clinical Geriatrics, Center for Alzheimer Research, Care Sciences and Society (NVS), Karolinska Institutet, Karolinska UniversitetssjukhusetInstitute of Clinical Medicine, Department of Neurology, University of Eastern FinlandInstitute of Clinical Medicine, Department of Neurology, University of Eastern FinlandInstitute of Clinical Medicine, Department of Neurology, University of Eastern FinlandInstitute of Clinical Medicine, Department of Neurology, University of Eastern FinlandPublic Health Promotion Unit, Finnish Institute for Health and WelfareInstitute of Clinical Medicine, Department of Neurology, University of Eastern FinlandInstitute of Clinical Medicine, Department of Neurology, University of Eastern FinlandInstitute of Clinical Medicine, Department of Neurology, University of Eastern FinlandInstitute of Clinical Medicine, Department of Neurology, University of Eastern FinlandPublic Health Promotion Unit, Finnish Institute for Health and WelfarePublic Health Promotion Unit, Finnish Institute for Health and WelfareInstitute of Clinical Medicine, Department of Neurology, University of Eastern FinlandInstitute of Clinical Medicine, Department of Neurology, University of Eastern FinlandAbstract Background The oldest old is the fastest growing age group worldwide and the most prone to severe disability, especially in relation to loss of cognitive function. Improving our understanding of the predictors of cognitive, physical and psychosocial wellbeing among the oldest old can result in substantial benefits for the individuals and for the society as a whole. The Cardiovascular Risk Factors, Aging and Dementia (CAIDE) study investigated risk factors and determinants of cognitive impairment in a population-based longitudinal cohort, which was first examined between 1972 and 1992, when individuals were in their midlife, and re-assessed in 1998 and 2005–2009. Most of the study participants are currently aged 85 years or older. We aim to re-examine the cohort’s survivors and gain further insights on the mechanisms underlying both cognitive and overall healthy ageing at old age. Methods CAIDE85+ is the third follow-up of the CAIDE study participants. All individuals still alive and living in the Kuopio and Joensuu areas of Eastern Finland, from the original CAIDE cohort (two random samples, N = 2000 + ~ 900), will be invited to a re-examination. The assessment includes self-reported data related to basic demographics and lifestyle, as well as psychosocial and physical health status. Cognitive and physical evaluations are also conducted. Blood biomarkers relevant for dementia and ageing are assessed. Primary outcomes are the measurements related to cognition and daily life functioning (CERAD, Trail Making Test-A, Letter-Digit Substitution Test, Clinical Dementia Rating and Activities of Daily Living). Secondary endpoints of the study are outcomes related to physical health status, psychosocial wellbeing, as well as age-related health indicators. Discussion Through a follow-up of more than 40 years, CAIDE85+ will provide invaluable information on the risk and protective factors that contribute to cognitive and physical health, as well as ageing and longevity. Study registration The present study protocol has been registered at https://clinicaltrials.gov/ (registration nr NCT03938727 , date 03.05.2019).http://link.springer.com/article/10.1186/s12877-020-01617-5AgeingCAIDECognitive declineDementiaDisabilityLongevity |