Cysteine 904 is required for maximal insulin degrading enzyme activity and polyanion activation.
Cysteine residues in insulin degrading enzyme have been reported as non-critical for its activity. We found that converting the twelve cysteine residues in rat insulin degrading enzyme (IDE) to serines resulted in a cysteine-free form of the enzyme with reduced activity and decreased activation by p...
Main Authors: | Eun Suk Song, Manana Melikishvili, Michael G Fried, Maria A Juliano, Luiz Juliano, David W Rodgers, Louis B Hersh |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3471918?pdf=render |
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