How N-Acetylcysteine Supplementation Affects Redox Regulation, Especially at Mitohormesis and Sarcohormesis Level: Current Perspective

How N-Acetylcysteine Supplementation Affects Redox Regulation, Especially at Mitohormesis and Sarcohormesis Level: Current Perspective

Exercise frequently alters the metabolic processes of oxidative metabolism in athletes, including exposure to extreme reactive oxygen species impairing exercise performance. Therefore, both researchers and athletes have been consistently investigating the possible strategies to improve metabolic ada...

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Bibliographic Details
Main Authors: Aslı Devrim-Lanpir, Lee Hill, Beat Knechtle
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Antioxidants
Subjects:
N-acetylcysteine
mitochondrial adaptation
skeletal adaptation
hormesis
oxidative stress
Online Access:https://www.mdpi.com/2076-3921/10/2/153
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spelling doaj-96e5f2ac47ec436a8f1c54121f43cd242021-01-22T00:02:18ZengMDPI AGAntioxidants2076-39212021-01-011015315310.3390/antiox10020153How N-Acetylcysteine Supplementation Affects Redox Regulation, Especially at Mitohormesis and Sarcohormesis Level: Current PerspectiveAslı Devrim-Lanpir0Lee Hill1Beat Knechtle2Department of Nutrition and Dietetics, Faculty of Health Sciences, Istanbul Medeniyet University, 34862 Istanbul, TurkeyDivision of Gastroenterology and Nutrition, Department of Pediatrics, McMaster University, Hamilton, ON L8S 4K1, CanadaMedbase St. Gallen am Vadianplatz, 9001 St. Gallen, SwitzerlandExercise frequently alters the metabolic processes of oxidative metabolism in athletes, including exposure to extreme reactive oxygen species impairing exercise performance. Therefore, both researchers and athletes have been consistently investigating the possible strategies to improve metabolic adaptations to exercise-induced oxidative stress. N-acetylcysteine (NAC) has been applied as a therapeutic agent in treating many diseases in humans due to its precursory role in the production of hepatic glutathione, a natural antioxidant. Several studies have investigated NAC’s possible therapeutic role in oxidative metabolism and adaptive response to exercise in the athletic population. However, still conflicting questions regarding NAC supplementation need to be clarified. This narrative review aims to re-evaluate the metabolic effects of NAC on exercise-induced oxidative stress and adaptive response developed by athletes against the exercise, especially mitohormetic and sarcohormetic response.https://www.mdpi.com/2076-3921/10/2/153N-acetylcysteinemitochondrial adaptationskeletal adaptationhormesisoxidative stress
collection DOAJ
language English
format Article
sources DOAJ
author Aslı Devrim-Lanpir
Lee Hill
Beat Knechtle
spellingShingle Aslı Devrim-Lanpir
Lee Hill
Beat Knechtle
How N-Acetylcysteine Supplementation Affects Redox Regulation, Especially at Mitohormesis and Sarcohormesis Level: Current Perspective
Antioxidants
N-acetylcysteine
mitochondrial adaptation
skeletal adaptation
hormesis
oxidative stress
author_facet Aslı Devrim-Lanpir
Lee Hill
Beat Knechtle
author_sort Aslı Devrim-Lanpir
title How N-Acetylcysteine Supplementation Affects Redox Regulation, Especially at Mitohormesis and Sarcohormesis Level: Current Perspective
title_short How N-Acetylcysteine Supplementation Affects Redox Regulation, Especially at Mitohormesis and Sarcohormesis Level: Current Perspective
title_full How N-Acetylcysteine Supplementation Affects Redox Regulation, Especially at Mitohormesis and Sarcohormesis Level: Current Perspective
title_fullStr How N-Acetylcysteine Supplementation Affects Redox Regulation, Especially at Mitohormesis and Sarcohormesis Level: Current Perspective
title_full_unstemmed How N-Acetylcysteine Supplementation Affects Redox Regulation, Especially at Mitohormesis and Sarcohormesis Level: Current Perspective
title_sort how n-acetylcysteine supplementation affects redox regulation, especially at mitohormesis and sarcohormesis level: current perspective
publisher MDPI AG
series Antioxidants
issn 2076-3921
publishDate 2021-01-01
description Exercise frequently alters the metabolic processes of oxidative metabolism in athletes, including exposure to extreme reactive oxygen species impairing exercise performance. Therefore, both researchers and athletes have been consistently investigating the possible strategies to improve metabolic adaptations to exercise-induced oxidative stress. N-acetylcysteine (NAC) has been applied as a therapeutic agent in treating many diseases in humans due to its precursory role in the production of hepatic glutathione, a natural antioxidant. Several studies have investigated NAC’s possible therapeutic role in oxidative metabolism and adaptive response to exercise in the athletic population. However, still conflicting questions regarding NAC supplementation need to be clarified. This narrative review aims to re-evaluate the metabolic effects of NAC on exercise-induced oxidative stress and adaptive response developed by athletes against the exercise, especially mitohormetic and sarcohormetic response.
topic N-acetylcysteine
mitochondrial adaptation
skeletal adaptation
hormesis
oxidative stress
url https://www.mdpi.com/2076-3921/10/2/153
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AT leehill hownacetylcysteinesupplementationaffectsredoxregulationespeciallyatmitohormesisandsarcohormesislevelcurrentperspective
AT beatknechtle hownacetylcysteinesupplementationaffectsredoxregulationespeciallyatmitohormesisandsarcohormesislevelcurrentperspective
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