The role of p21/CIP1/WAF1 (p21) in the negative regulation of the growth hormone/growth hormone receptor and epidermal growth factor/epidermal growth factor receptor pathways, in growth hormone transduction defect

The role of p21/CIP1/WAF1 (p21) in the negative regulation of the growth hormone/growth hormone receptor and epidermal growth factor/epidermal growth factor receptor pathways, in growth hormone transduction defect

Purpose Growth hormone transduction defect (GHTD) is characterized by severe short stature, impaired STAT3 (signal transducer and activator of transcription-3) phosphorylation and overexpression of the cytokine inducible SH2 containing protein (CIS) and p21/CIP1/WAF1. To investigate the role of p21/...

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Bibliographic Details
Main Authors: Eirini Kostopoulou, Andrea Paola Rojas Gil, Bessie E. Spiliotis
Format: Article
Language:English
Published: Korean Society of Pediatric Endocrinology 2018-12-01
Series:Annals of Pediatric Endocrinology & Metabolism
Subjects:
Cyclin-dependent kinase inhibitor p21
Feedback signal transduction
Growth hormone
Epidermal growth factor
Cell cycle
Cyclin-dependent kinases
Online Access:http://e-apem.org/upload/pdf/apem-2018-23-4-204.pdf

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