Human telomere length correlates to the size of the associated chromosome arm.
The majority of human telomere length studies have focused on the overall length of telomeres within a cell. In fact, very few studies have examined telomere length for individual chromosome arms. The objective of this study was to examine the relationship between chromosome arm size and the relativ...
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doaj-96f1396eb1a14c3bb10a4694d614585b2020-11-25T00:02:09ZengPublic Library of Science (PLoS)PLoS ONE1932-62032009-06-0146e601310.1371/journal.pone.0006013Human telomere length correlates to the size of the associated chromosome arm.Jasen L WiseRichard J CroutDaniel W McNeilRobert J WeyantMary L MarazitaSharon L WengerThe majority of human telomere length studies have focused on the overall length of telomeres within a cell. In fact, very few studies have examined telomere length for individual chromosome arms. The objective of this study was to examine the relationship between chromosome arm size and the relative length of the associated telomere. Quantitative Fluorescence In Situ Hybridization (Q-FISH) was used to measure the relative telomere length of each chromosome arm in metaphases from cultured lymphocytes of 17 individuals. A statistically significant positive correlation (r = 0.6) was found between telomere length and the size of the associated chromosome arm, which was estimated based on megabase pair measurements from (http://www.ncbi.nlm.nih.gov/projects/mapview/).http://europepmc.org/articles/PMC2695537?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jasen L Wise Richard J Crout Daniel W McNeil Robert J Weyant Mary L Marazita Sharon L Wenger |
spellingShingle |
Jasen L Wise Richard J Crout Daniel W McNeil Robert J Weyant Mary L Marazita Sharon L Wenger Human telomere length correlates to the size of the associated chromosome arm. PLoS ONE |
author_facet |
Jasen L Wise Richard J Crout Daniel W McNeil Robert J Weyant Mary L Marazita Sharon L Wenger |
author_sort |
Jasen L Wise |
title |
Human telomere length correlates to the size of the associated chromosome arm. |
title_short |
Human telomere length correlates to the size of the associated chromosome arm. |
title_full |
Human telomere length correlates to the size of the associated chromosome arm. |
title_fullStr |
Human telomere length correlates to the size of the associated chromosome arm. |
title_full_unstemmed |
Human telomere length correlates to the size of the associated chromosome arm. |
title_sort |
human telomere length correlates to the size of the associated chromosome arm. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2009-06-01 |
description |
The majority of human telomere length studies have focused on the overall length of telomeres within a cell. In fact, very few studies have examined telomere length for individual chromosome arms. The objective of this study was to examine the relationship between chromosome arm size and the relative length of the associated telomere. Quantitative Fluorescence In Situ Hybridization (Q-FISH) was used to measure the relative telomere length of each chromosome arm in metaphases from cultured lymphocytes of 17 individuals. A statistically significant positive correlation (r = 0.6) was found between telomere length and the size of the associated chromosome arm, which was estimated based on megabase pair measurements from (http://www.ncbi.nlm.nih.gov/projects/mapview/). |
url |
http://europepmc.org/articles/PMC2695537?pdf=render |
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