Communications between Mitochondria and Endoplasmic Reticulum in the Regulation of Metabolic Homeostasis

Mitochondria associated membranes (MAM), which are the contact sites between endoplasmic reticulum (ER) and mitochondria, have emerged as an important hub for signaling molecules to integrate the cellular and organelle homeostasis, thus facilitating the adaptation of energy metabolism to nutrient st...

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Main Authors:	Pengcheng Zhang, Daniels Konja, Yiwei Zhang, Yu Wang
Format:	Article
Language:	English
Published:	MDPI AG 2021-08-01
Series:	Cells
Subjects:	mitochondria endoplasmic reticulum MAM energy metabolism
Online Access:	https://www.mdpi.com/2073-4409/10/9/2195

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spelling	doaj-96f49eb275634f43bda665fd557ca75c2021-09-25T23:51:50ZengMDPI AGCells2073-44092021-08-01102195219510.3390/cells10092195Communications between Mitochondria and Endoplasmic Reticulum in the Regulation of Metabolic HomeostasisPengcheng Zhang0Daniels Konja1Yiwei Zhang2Yu Wang3The State Key Laboratory of Pharmaceutical Biotechnology, Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong SAR, ChinaThe State Key Laboratory of Pharmaceutical Biotechnology, Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong SAR, ChinaThe State Key Laboratory of Pharmaceutical Biotechnology, Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong SAR, ChinaThe State Key Laboratory of Pharmaceutical Biotechnology, Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong SAR, ChinaMitochondria associated membranes (MAM), which are the contact sites between endoplasmic reticulum (ER) and mitochondria, have emerged as an important hub for signaling molecules to integrate the cellular and organelle homeostasis, thus facilitating the adaptation of energy metabolism to nutrient status. This review explores the dynamic structural and functional features of the MAM and summarizes the various abnormalities leading to the impaired insulin sensitivity and metabolic diseases.https://www.mdpi.com/2073-4409/10/9/2195mitochondriaendoplasmic reticulumMAMenergy metabolism
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Pengcheng Zhang Daniels Konja Yiwei Zhang Yu Wang
spellingShingle	Pengcheng Zhang Daniels Konja Yiwei Zhang Yu Wang Communications between Mitochondria and Endoplasmic Reticulum in the Regulation of Metabolic Homeostasis Cells mitochondria endoplasmic reticulum MAM energy metabolism
author_facet	Pengcheng Zhang Daniels Konja Yiwei Zhang Yu Wang
author_sort	Pengcheng Zhang
title	Communications between Mitochondria and Endoplasmic Reticulum in the Regulation of Metabolic Homeostasis
title_short	Communications between Mitochondria and Endoplasmic Reticulum in the Regulation of Metabolic Homeostasis
title_full	Communications between Mitochondria and Endoplasmic Reticulum in the Regulation of Metabolic Homeostasis
title_fullStr	Communications between Mitochondria and Endoplasmic Reticulum in the Regulation of Metabolic Homeostasis
title_full_unstemmed	Communications between Mitochondria and Endoplasmic Reticulum in the Regulation of Metabolic Homeostasis
title_sort	communications between mitochondria and endoplasmic reticulum in the regulation of metabolic homeostasis
publisher	MDPI AG
series	Cells
issn	2073-4409
publishDate	2021-08-01
description	Mitochondria associated membranes (MAM), which are the contact sites between endoplasmic reticulum (ER) and mitochondria, have emerged as an important hub for signaling molecules to integrate the cellular and organelle homeostasis, thus facilitating the adaptation of energy metabolism to nutrient status. This review explores the dynamic structural and functional features of the MAM and summarizes the various abnormalities leading to the impaired insulin sensitivity and metabolic diseases.
topic	mitochondria endoplasmic reticulum MAM energy metabolism
url	https://www.mdpi.com/2073-4409/10/9/2195
work_keys_str_mv	AT pengchengzhang communicationsbetweenmitochondriaandendoplasmicreticulumintheregulationofmetabolichomeostasis AT danielskonja communicationsbetweenmitochondriaandendoplasmicreticulumintheregulationofmetabolichomeostasis AT yiweizhang communicationsbetweenmitochondriaandendoplasmicreticulumintheregulationofmetabolichomeostasis AT yuwang communicationsbetweenmitochondriaandendoplasmicreticulumintheregulationofmetabolichomeostasis
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Communications between Mitochondria and Endoplasmic Reticulum in the Regulation of Metabolic Homeostasis

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