Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor

Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor

Genetic and biochemical evidence attributes neuronal loss in Parkinson’s disease (PD) and related brain diseases to dyshomeostasis of the 14 kDa protein α-synuclein (αS). There is no consensus on how αS exerts toxicity. Explanations range from disturbed vesicle biology to proteotoxicity caused by fi...

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Bibliographic Details
Main Authors: Elizabeth Terry-Kantor, Arati Tripathi, Thibaut Imberdis, Zachary M. LaVoie, Gary P. H. Ho, Dennis Selkoe, Saranna Fanning, Nagendran Ramalingam, Ulf Dettmer
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
alpha-synuclein
protein misfolding
Parkinson’s disease
Lewy body dementia
neurotoxicity
stearoyl-CoA desaturase
Online Access:https://www.mdpi.com/1422-0067/21/15/5193

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