In vitro expression of natural mutants of human lecithin:cholesterol acyltransferase.
Fish-eye disease (FED) and familial lecithin:cholesterol acyltransferase (LCAT) deficiency (FLD) are rare disorders of lipid metabolism linked to mutations in the LCAT gene. Eleven LCAT cDNA constructs associated with FED and FLD were prepared by site-directed mutagenesis and expressed in COS-6 cell...
Main Authors: | S J Qu, H Z Fan, F Blanco-Vaca, H J Pownall |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
1995-05-01
|
Series: | Journal of Lipid Research |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520398540 |
Similar Items
-
The plasma lecithin:cholesterol acyltransferase reaction
by: John A. Glomset
Published: (1968-03-01) -
Expression and characterization of recombinant human lecithin:cholesterol acyltransferase
by: JS Hill, et al.
Published: (1993-07-01) -
New substrate for determination of serum lecithin:cholesterol acyltransferase
by: M Manabe, et al.
Published: (1987-10-01) -
The molecular pathology of lecithin:cholesterol acyltransferase (LCAT) deficiency syndromes
by: J A Kuivenhoven, et al.
Published: (1997-02-01) -
Effects of natural mutations in lecithin:cholesterol acyltransferase on the enzyme structure and activity
by: F. Peelman, et al.
Published: (1999-01-01)