Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s Disease

Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. No disease-modifying strategy to prevent or delay AD progression currently exists. Aβ oligomers (AβOs), rather than monomers or fibrils, are considered as the primary neurotoxic species. Therapeutic approaches...

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Main Authors:	Xiao-ge Liu, Lun Zhang, Shuai Lu, Dong-qun Liu, Ya-ru Huang, Jie Zhu, Wei-wei Zhou, Xiao-lin Yu, Rui-tian Liu
Format:	Article
Language:	English
Published:	BMC 2020-11-01
Series:	Journal of Nanobiotechnology
Subjects:	Alzheimer’s disease β-Amyloid Oligomer Class A scavenger receptor Therapy
Online Access:	http://link.springer.com/article/10.1186/s12951-020-00723-1

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spelling	doaj-96ff639954c94c9cba334d83b238166b2020-11-25T04:06:52ZengBMCJournal of Nanobiotechnology1477-31552020-11-0118111310.1186/s12951-020-00723-1Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s DiseaseXiao-ge Liu0Lun Zhang1Shuai Lu2Dong-qun Liu3Ya-ru Huang4Jie Zhu5Wei-wei Zhou6Xiao-lin Yu7Rui-tian Liu8State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of SciencesState Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of SciencesState Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of SciencesState Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of SciencesState Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of SciencesState Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of SciencesState Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of SciencesState Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of SciencesState Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of SciencesAbstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. No disease-modifying strategy to prevent or delay AD progression currently exists. Aβ oligomers (AβOs), rather than monomers or fibrils, are considered as the primary neurotoxic species. Therapeutic approaches that direct against AβOs and promote Aβ clearance may have great value for AD treatment. Results We here reported a multifunctional superparamagnetic iron oxide nanoparticle conjugated with Aβ oligomer-specific scFv antibody W20 and class A scavenger receptor activator XD4 (W20/XD4-SPIONs). Besides the diagnostic value, W20/XD4-SPIONs retained the anti-Aβ properties of W20 and XD4 by inhibiting Aβ aggregation, attenuating AβO-induced cytotoxicity and increasing microglial phagocytosis of Aβ. When applied to APP/PS1 mice, W20/XD4-SPIONs significantly rescued cognitive deficits and alleviated neuropathology of AD mice. Conclusion These results suggest that W20/XD4-SPIONs show therapeutic benefits for AD. In combination with the early diagnostic property, W20/XD4-SPIONs present as a promising agent for early-stage AD diagnosis and intervention.http://link.springer.com/article/10.1186/s12951-020-00723-1Alzheimer’s diseaseβ-AmyloidOligomerClass A scavenger receptorTherapy
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Xiao-ge Liu Lun Zhang Shuai Lu Dong-qun Liu Ya-ru Huang Jie Zhu Wei-wei Zhou Xiao-lin Yu Rui-tian Liu
spellingShingle	Xiao-ge Liu Lun Zhang Shuai Lu Dong-qun Liu Ya-ru Huang Jie Zhu Wei-wei Zhou Xiao-lin Yu Rui-tian Liu Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s Disease Journal of Nanobiotechnology Alzheimer’s disease β-Amyloid Oligomer Class A scavenger receptor Therapy
author_facet	Xiao-ge Liu Lun Zhang Shuai Lu Dong-qun Liu Ya-ru Huang Jie Zhu Wei-wei Zhou Xiao-lin Yu Rui-tian Liu
author_sort	Xiao-ge Liu
title	Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s Disease
title_short	Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s Disease
title_full	Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s Disease
title_fullStr	Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s Disease
title_full_unstemmed	Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s Disease
title_sort	superparamagnetic iron oxide nanoparticles conjugated with aβ oligomer-specific scfv antibody and class a scavenger receptor activator show therapeutic potentials for alzheimer’s disease
publisher	BMC
series	Journal of Nanobiotechnology
issn	1477-3155
publishDate	2020-11-01
description	Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. No disease-modifying strategy to prevent or delay AD progression currently exists. Aβ oligomers (AβOs), rather than monomers or fibrils, are considered as the primary neurotoxic species. Therapeutic approaches that direct against AβOs and promote Aβ clearance may have great value for AD treatment. Results We here reported a multifunctional superparamagnetic iron oxide nanoparticle conjugated with Aβ oligomer-specific scFv antibody W20 and class A scavenger receptor activator XD4 (W20/XD4-SPIONs). Besides the diagnostic value, W20/XD4-SPIONs retained the anti-Aβ properties of W20 and XD4 by inhibiting Aβ aggregation, attenuating AβO-induced cytotoxicity and increasing microglial phagocytosis of Aβ. When applied to APP/PS1 mice, W20/XD4-SPIONs significantly rescued cognitive deficits and alleviated neuropathology of AD mice. Conclusion These results suggest that W20/XD4-SPIONs show therapeutic benefits for AD. In combination with the early diagnostic property, W20/XD4-SPIONs present as a promising agent for early-stage AD diagnosis and intervention.
topic	Alzheimer’s disease β-Amyloid Oligomer Class A scavenger receptor Therapy
url	http://link.springer.com/article/10.1186/s12951-020-00723-1
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Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s Disease

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