A graphical assessment of p-values from sliding window haplotype tests of association to identify asthma susceptibility loci on chromosome 11q
<p>Abstract</p> <p>Background</p> <p>Past work on asthmatic African American families revealed a strong linkage peak with modest evidence of association on chromosome 11q. Here, we perform tests of association for asthma and a panel of 609 SNPs in African American subje...
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doaj-970455afb1064baeabbe1b2e8c62f1dc2020-11-25T04:00:33ZengBMCBMC Genetics1471-21562006-06-01713810.1186/1471-2156-7-38A graphical assessment of p-values from sliding window haplotype tests of association to identify asthma susceptibility loci on chromosome 11qTogias AlkisMalveaux Floyd JDunston Georgia MFurbert-Harris PaulettePugh Elizabeth WWilson Alexander FGoldstein Janet LGao PeisongMathias Rasika ABarnes Kathleen CBeaty Terri HHuang Shau-Ku<p>Abstract</p> <p>Background</p> <p>Past work on asthmatic African American families revealed a strong linkage peak with modest evidence of association on chromosome 11q. Here, we perform tests of association for asthma and a panel of 609 SNPs in African American subjects using a sliding window approach. While efficient in screening a region of dense genotyping, this approach does create some problems: high numbers of tests, assimilating thousands of results, and questions about setting priorities on regions with association signals.</p> <p>Results</p> <p>We present a newly developed tool, Graphical Assessment of Sliding P-values or GrASP, which uses color display to indicate the width of the sliding windows, significance of individual tests, density of SNP coverage and location of known genes that simplifies some of these issues, and use it to identify regions of interest in these data.</p> <p>Conclusion</p> <p>We demonstrate that GrASP makes it easier to visualize, summarize and prioritize regions of interest from sliding window haplotype analysis, based jointly on the p-value from all the tests from these windows and the building of haplotypes of significance in the region. Using this approach, five regions yielded strong evidence for linkage and association with asthma, including the prior peak linkage region.</p> http://www.biomedcentral.com/1471-2156/7/38 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Togias Alkis Malveaux Floyd J Dunston Georgia M Furbert-Harris Paulette Pugh Elizabeth W Wilson Alexander F Goldstein Janet L Gao Peisong Mathias Rasika A Barnes Kathleen C Beaty Terri H Huang Shau-Ku |
spellingShingle |
Togias Alkis Malveaux Floyd J Dunston Georgia M Furbert-Harris Paulette Pugh Elizabeth W Wilson Alexander F Goldstein Janet L Gao Peisong Mathias Rasika A Barnes Kathleen C Beaty Terri H Huang Shau-Ku A graphical assessment of p-values from sliding window haplotype tests of association to identify asthma susceptibility loci on chromosome 11q BMC Genetics |
author_facet |
Togias Alkis Malveaux Floyd J Dunston Georgia M Furbert-Harris Paulette Pugh Elizabeth W Wilson Alexander F Goldstein Janet L Gao Peisong Mathias Rasika A Barnes Kathleen C Beaty Terri H Huang Shau-Ku |
author_sort |
Togias Alkis |
title |
A graphical assessment of p-values from sliding window haplotype tests of association to identify asthma susceptibility loci on chromosome 11q |
title_short |
A graphical assessment of p-values from sliding window haplotype tests of association to identify asthma susceptibility loci on chromosome 11q |
title_full |
A graphical assessment of p-values from sliding window haplotype tests of association to identify asthma susceptibility loci on chromosome 11q |
title_fullStr |
A graphical assessment of p-values from sliding window haplotype tests of association to identify asthma susceptibility loci on chromosome 11q |
title_full_unstemmed |
A graphical assessment of p-values from sliding window haplotype tests of association to identify asthma susceptibility loci on chromosome 11q |
title_sort |
graphical assessment of p-values from sliding window haplotype tests of association to identify asthma susceptibility loci on chromosome 11q |
publisher |
BMC |
series |
BMC Genetics |
issn |
1471-2156 |
publishDate |
2006-06-01 |
description |
<p>Abstract</p> <p>Background</p> <p>Past work on asthmatic African American families revealed a strong linkage peak with modest evidence of association on chromosome 11q. Here, we perform tests of association for asthma and a panel of 609 SNPs in African American subjects using a sliding window approach. While efficient in screening a region of dense genotyping, this approach does create some problems: high numbers of tests, assimilating thousands of results, and questions about setting priorities on regions with association signals.</p> <p>Results</p> <p>We present a newly developed tool, Graphical Assessment of Sliding P-values or GrASP, which uses color display to indicate the width of the sliding windows, significance of individual tests, density of SNP coverage and location of known genes that simplifies some of these issues, and use it to identify regions of interest in these data.</p> <p>Conclusion</p> <p>We demonstrate that GrASP makes it easier to visualize, summarize and prioritize regions of interest from sliding window haplotype analysis, based jointly on the p-value from all the tests from these windows and the building of haplotypes of significance in the region. Using this approach, five regions yielded strong evidence for linkage and association with asthma, including the prior peak linkage region.</p> |
url |
http://www.biomedcentral.com/1471-2156/7/38 |
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