Spatial Gradient of Microstructural Changes in Normal-Appearing White Matter in Tracts Affected by White Matter Hyperintensities in Older Age

Spatial Gradient of Microstructural Changes in Normal-Appearing White Matter in Tracts Affected by White Matter Hyperintensities in Older Age

Background and Purpose: White matter hyperintensities (WMH) are commonly seen on structural MRI of older adults and are a manifestation of underlying and adjacent tissue damage. WMH may contribute to cortical disconnection and cognitive dysfunction, but it is unclear how WMH affect intersecting or n...

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Bibliographic Details
Main Authors: Susana Muñoz Maniega, Rozanna Meijboom, Francesca M. Chappell, Maria del C. Valdés Hernández, John M. Starr, Mark E. Bastin, Ian J. Deary, Joanna M. Wardlaw
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Neurology
Subjects:
brain
aging
diffusion MRI
white matter hyperintensities
tractography
cerebral small vessel disease
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.00784/full

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https://www.frontiersin.org/article/10.3389/fneur.2019.00784/full

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